STRINGSTRING
KCNJ11 KCNJ11 TGFB3 TGFB3 AKAP6 AKAP6 CACNB3 CACNB3 VDR VDR SLC30A1 SLC30A1 ATP2B4 ATP2B4 ENSPPYP00000000415 ENSPPYP00000000415 ATP1B1 ATP1B1 CR201_G0042066 CR201_G0042066 CASQ1 CASQ1 ATP1A2 ATP1A2 ATP1A1 ATP1A1 SLC9A1 SLC9A1 CACNB2 CACNB2 PPP3CB PPP3CB ANK3 ANK3 ENSPPYP00000007041 ENSPPYP00000007041 RDX RDX CACNA1C CACNA1C STBD1 STBD1 ADRA1A ADRA1A CACNA2D1 CACNA2D1 ANK2 ANK2 STAC STAC SCN5A SCN5A CACNA1D CACNA1D CAV3 CAV3 SCN2A SCN2A SCN1A SCN1A KCNJ3 KCNJ3 BIN1 BIN1 SLC8A1 SLC8A1 ASB3 ASB3 DYSF DYSF FER1L5 FER1L5 CACNG6 CACNG6 CACNG7 CACNG7 RTN2 RTN2 FXYD1 FXYD1 SCN1B SCN1B AQP4 AQP4 KCNJ2 KCNJ2 CACNG1 CACNG1 CACNG4 CACNG4 SLC2A4 SLC2A4 IGF1R IGF1R CAPN3 CAPN3 ENSPPYP00000007042 ENSPPYP00000007042
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
AKAP6A-kinase anchoring protein 6. (2319 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
VDRVDR isoform 4. (486 aa)
SLC30A1Solute carrier family 30 member 1. (507 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1110 aa)
ENSPPYP00000000415annotation not available (1220 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). (303 aa)
CR201_G0042066C1orf226 isoform 2. (695 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (398 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha-2; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients (By similarity). Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. (1020 aa)
ATP1A1ATP1A1 isoform 7. (1003 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (612 aa)
PPP3CBSerine/threonine-protein phosphatase. (438 aa)
ANK3ANK3 isoform 1. (4275 aa)
ENSPPYP00000007041annotation not available (1633 aa)
RDXRDX isoform 3. (604 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2160 aa)
STBD1Starch binding domain 1. (358 aa)
ADRA1AAdrenoceptor alpha 1A. (427 aa)
CACNA2D1CACNA2D1 isoform 1. (1087 aa)
ANK2ANK2 isoform 1. (4018 aa)
STACSH3 and cysteine rich domain. (402 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1523 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2077 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa)
SCN2ASodium channel protein type 2 subunit alpha. (1165 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2009 aa)
KCNJ3KCNJ3 isoform 2. (416 aa)
BIN1BIN1 isoform 9. (517 aa)
SLC8A1SLC8A1 isoform 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
ASB3Ankyrin repeat and SOCS box containing 3. (559 aa)
DYSFDYSF isoform 11. (1710 aa)
FER1L5FER1L5 isoform 6. (801 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (159 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
RTN2Reticulon. (472 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (92 aa)
SCN1BSCN1B isoform 1. (218 aa)
AQP4AQP4 isoform 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (222 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (268 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
CAPN3CAPN3 isoform 16; Belongs to the peptidase C2 family. (815 aa)
ENSPPYP00000007042annotation not available (640 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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