STRINGSTRING
HJV HJV LEFTY2 LEFTY2 ENSPPYP00000000171 ENSPPYP00000000171 TGFB2 TGFB2 TGFBR3 TGFBR3 BMP8B BMP8B CR201_G0015593 CR201_G0015593 GDF2 GDF2 BMPR1A BMPR1A NODAL NODAL PDCD4 PDCD4 GDF3 GDF3 ACVRL1 ACVRL1 SLC39A5 SLC39A5 SPART SPART CR201_G0000132 CR201_G0000132 BMP4 BMP4 TGFB3 TGFB3 SMAD6 SMAD6 SMAD3 SMAD3 MAPK3 MAPK3 SMPD3 SMPD3 FAM83G FAM83G NOG NOG TMEM100 TMEM100 SOST SOST DLX3 DLX3 TWSG1 TWSG1 DSG4 DSG4 SMAD7 SMAD7 SMAD4 SMAD4 GDF15 GDF15 FKBP8 FKBP8 ETV2 ETV2 TGFB1 TGFB1 ZNF8 ZNF8 GDF5 GDF5 BMP7 BMP7 ZNF831 ZNF831 TMPRSS6 TMPRSS6 CCDC142 CCDC142 BMP10 BMP10 GDF7 GDF7 ACVR2A ACVR2A ACVR1 ACVR1 ATF2 ATF2 BMPR2 BMPR2 PPARG PPARG WNT5A WNT5A ACVR2B ACVR2B SLC33A1 SLC33A1 CHRD CHRD HES1 HES1 MSX1 MSX1 BMPR1B BMPR1B LEF1 LEF1 ENSPPYP00000016868 ENSPPYP00000016868 SMAD1 SMAD1 SFRP2 SFRP2 FST FST RGMB RGMB GDF9 GDF9 SMAD5 SMAD5 BMP6 BMP6 HIVEP1 HIVEP1 HFE HFE RUNX2 RUNX2 BMP5 BMP5 SMURF1 SMURF1 BMPER BMPER SOSTDC1 SOSTDC1 DLX5 DLX5 CR201_G0033322 CR201_G0033322 GDF6 GDF6 EXT1 EXT1 SCX SCX ENG ENG CR201_G0027499 CR201_G0027499 ABL1 ABL1 USP9X USP9X BMP15 BMP15 CHRDL1 CHRDL1 ZCCHC12 ZCCHC12 USP15 USP15 BMP2 BMP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HJVHFE2 isoform 3. (425 aa)
LEFTY2Left-right determination factor. (366 aa)
ENSPPYP00000000171Left-right determination factor 1 isoform X1. (366 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
TGFBR3TGFBR3 isoform 1. (859 aa)
BMP8BBMP8B isoform 1. (336 aa)
CR201_G0015593BMP8A isoform 1. (357 aa)
GDF2Growth differentiation factor 2. (429 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NODALNodal growth differentiation factor. (347 aa)
PDCD4Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). Belongs to the PDCD4 family. (468 aa)
GDF3Growth differentiation factor 3. (364 aa)
ACVRL1Serine/threonine-protein kinase receptor R3; Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well (By similarity). (503 aa)
SLC39A5SLC39A5 isoform 1. (538 aa)
SPARTSPART isoform 1. (666 aa)
CR201_G0000132SMAD1 isoform 8. (430 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SMAD6Mothers against decapentaplegic homolog. (404 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa)
SMPD3SMPD3 isoform 1. (629 aa)
FAM83GFAM83G isoform 1. (823 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TMEM100Transmembrane protein 100. (134 aa)
SOSTSOST isoform 1. (245 aa)
DLX3Distal-less homeobox 3. (287 aa)
TWSG1Twisted gastrulation protein homolog 1; May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity); Belongs to the twisted gastrulation protei [...] (223 aa)
DSG4DSG4 isoform 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1040 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GDF15Growth differentiation factor 15. (308 aa)
FKBP8Peptidylprolyl isomerase. (413 aa)
ETV2ETV2 isoform 4. (370 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
ZNF8ZNF8 isoform 1. (575 aa)
GDF5Growth differentiation factor 5. (501 aa)
BMP7Bone morphogenetic protein 7. (365 aa)
ZNF831ZNF831 isoform 1. (1514 aa)
TMPRSS6TMPRSS6 isoform 2; Belongs to the peptidase S1 family. (713 aa)
CCDC142Coiled-coil domain containing 142. (750 aa)
BMP10BMP10 isoform 1. (424 aa)
GDF7GDF7 isoform 1. (447 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
PPARGPeroxisome proliferator-activated receptor gamma. (477 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (473 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
SLC33A1Solute carrier family 33 member 1. (550 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (938 aa)
HES1HES1 isoform 1. (198 aa)
MSX1MSX1 isoform 1. (261 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (492 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
ENSPPYP00000016868annotation not available (85 aa)
SMAD1Mothers against decapentaplegic homolog. (73 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
FSTFST isoform 1. (344 aa)
RGMBRGMB isoform 2. (591 aa)
GDF9Growth differentiation factor 9. (455 aa)
SMAD5Mothers against decapentaplegic homolog 5; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor- regulated SMAD (R-SMAD) (By similarity). (465 aa)
BMP6BMP6 isoform 1. (510 aa)
HIVEP1HIVEP1 isoform 4. (2705 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (589 aa)
BMP5BMP5 isoform 1. (453 aa)
SMURF1E3 ubiquitin-protein ligase. (838 aa)
BMPERBMPER isoform 1. (376 aa)
SOSTDC1Sclerostin domain-containing protein 1; Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. Enhances Wnt signaling and inhibits TGF-beta signaling. May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction (By similarity). (206 aa)
DLX5Distal-less homeobox 5. (289 aa)
CR201_G0033322SFRP1 isoform 1. (260 aa)
GDF6Growth differentiation factor 6. (455 aa)
EXT1Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). (746 aa)
SCXSCX isoform 1. (200 aa)
ENGENG isoform 3. (668 aa)
CR201_G0027499ABL1 isoform 3. (48 aa)
ABL1Tyrosine-protein kinase. (948 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2554 aa)
BMP15BMP15 isoform 1. (393 aa)
CHRDL1CHRDL1 isoform 4. (456 aa)
ZCCHC12Zinc finger CCHC-type containing 12. (402 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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