STRINGSTRING
LEMD3 LEMD3 CHST11 CHST11 ING1 ING1 BRMS1L BRMS1L NKX2-1 NKX2-1 PPM1A PPM1A TGFB3 TGFB3 FBN1 FBN1 ONECUT1 ONECUT1 SMAD6 SMAD6 SIN3A SIN3A WFIKKN1 WFIKKN1 ARID4B ARID4B STUB1 STUB1 PDPK1 PDPK1 VASN VASN GLG1 GLG1 TGFB1I1 TGFB1I1 TP53 TP53 WFIKKN2 WFIKKN2 SMURF2 SMURF2 LDLRAD4 LDLRAD4 CIDEA CIDEA SKOR2 SKOR2 SMAD7 SMAD7 ONECUT2 ONECUT2 LINGO3 LINGO3 PIN1 PIN1 DNM2 DNM2 DAND5 DAND5 SPRED3 SPRED3 ZBTB7A ZBTB7A SPINT3 SPINT3 SLC2A10 SLC2A10 PMEPA1 PMEPA1 XBP1 XBP1 PPARA PPARA SPRED2 SPRED2 EMILIN1 EMILIN1 ADAM17 ADAM17 SAP130 SAP130 PPARG PPARG IL17RD IL17RD VEPH1 VEPH1 CR201_G0034676 CR201_G0034676 SKIL SKIL NRROS NRROS HTRA3 HTRA3 RASL11B RASL11B SPRY1 SPRY1 SAP30 SAP30 ING2 ING2 CR201_G0037904 CR201_G0037904 FBN2 FBN2 SAP30L SAP30L CD109 CD109 HDAC2 HDAC2 SMURF1 SMURF1 CAV2 CAV2 CAV1 CAV1 ASPN ASPN HSPA5 HSPA5 ENG ENG ADAMTSL2 ADAMTSL2 ENSPPYP00000022901 ENSPPYP00000022901 OGT OGT BMP2 BMP2 MTMR4 MTMR4 ZNF451 ZNF451 TGFBR3 TGFBR3 PRDM16 PRDM16 SKI SKI BAMBI BAMBI TET1 TET1 PBLD PBLD SIRT1 SIRT1 HTRA1 HTRA1 FAM89B FAM89B BCL9L BCL9L BRMS1 BRMS1 STRAP STRAP WNT1 WNT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LEMD3LEMD3 isoform 1. (796 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
ING1Inhibitor of growth protein. (279 aa)
BRMS1LBRMS1 like transcriptional repressor. (323 aa)
NKX2-1NKX2-1 isoform 1. (401 aa)
PPM1APPM1A isoform 1. (382 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
FBN1FBN1 isoform 1. (2871 aa)
ONECUT1One cut domain family member. (465 aa)
SMAD6Mothers against decapentaplegic homolog. (404 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
WFIKKN1WFIKKN1 isoform 1. (547 aa)
ARID4BAT-rich interaction domain 4B. (1313 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
PDPK1PDPK1 isoform 1. (495 aa)
VASNVASN isoform 1. (673 aa)
GLG1GLG1 isoform 1. (1062 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (461 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
WFIKKN2WFIKKN2 isoform 1. (575 aa)
SMURF2E3 ubiquitin-protein ligase. (877 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
CIDEACell death inducing DFFA like effector a. (219 aa)
SKOR2SKOR2 isoform 1. (294 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
ONECUT2One cut domain family member. (472 aa)
LINGO3LINGO3 isoform 1. (608 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
DNM2DNM2 isoform 6; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (866 aa)
DAND5DAN domain BMP antagonist family member 5. (189 aa)
SPRED3Sprouty related EVH1 domain containing 3. (410 aa)
ZBTB7AZBTB7A isoform 1. (421 aa)
SPINT3Serine peptidase inhibitor, Kunitz type 3. (89 aa)
SLC2A10SLC2A10 isoform 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (541 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (252 aa)
XBP1X-box binding protein 1. (262 aa)
PPARAPeroxisome proliferator activated receptor alpha. (474 aa)
SPRED2Sprouty-related, EVH1 domain-containing protein 2; Negatively regulates Ras signaling pathways and downstream activation of MAP kinases. (418 aa)
EMILIN1Elastin microfibril interfacer 1. (1016 aa)
ADAM17ADAM17 isoform 1. (725 aa)
SAP130SAP130 isoform 1. (935 aa)
PPARGPeroxisome proliferator-activated receptor gamma. (477 aa)
IL17RDInterleukin 17 receptor D. (739 aa)
VEPH1VEPH1 isoform 1. (793 aa)
CR201_G0034676MECOM isoform 19. (118 aa)
SKILSki-like protein; May have regulatory role in cell division or differentiation in response to extracellular signals. (675 aa)
NRROSNRROS isoform 1. (692 aa)
HTRA3HTRA3 isoform 1. (448 aa)
RASL11BRAS like family 11 member B. (248 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
SAP30Uncharacterized protein. (198 aa)
ING2Inhibitor of growth protein. (280 aa)
CR201_G0037904SNX25 isoform 1. (664 aa)
FBN2FBN2 isoform 1. (2909 aa)
SAP30LSAP30L isoform 1. (183 aa)
CD109CD109 isoform 3. (1445 aa)
HDAC2Histone deacetylase 2. (580 aa)
SMURF1E3 ubiquitin-protein ligase. (838 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
CAV1Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...] (178 aa)
ASPNAsporin. (376 aa)
HSPA5Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (654 aa)
ENGENG isoform 3. (668 aa)
ADAMTSL2ADAMTSL2 isoform 1. (955 aa)
ENSPPYP00000022901annotation not available (42 aa)
OGTOGT isoform 1. (1045 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
MTMR4Myotubularin related protein 4. (1227 aa)
ZNF451ZNF451 isoform 2. (1061 aa)
TGFBR3TGFBR3 isoform 1. (859 aa)
PRDM16PRDM16 isoform 5. (1092 aa)
SKISKI isoform 1. (406 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
TET1TET1 isoform 1. (2136 aa)
PBLDPhenazine biosynthesis-like domain-containing protein. (288 aa)
SIRT1SIRT1 isoform 1. (746 aa)
HTRA1HTRA1 isoform 1. (522 aa)
FAM89BFamily with sequence similarity 89 member B. (176 aa)
BCL9LBCL9L isoform 4. (1542 aa)
BRMS1BRMS1 transcriptional repressor and anoikis regulator. (246 aa)
STRAPSTRAP isoform 3. (350 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.