(56 nodes) Phagocytic vesicle membrane network (Pongo abelii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	ATP6V0B	ATP6V0B isoform 3; Belongs to the V-ATPase proteolipid subunit family. (156 aa)
	INPP5B	INPP5B isoform 1. (877 aa)
	VAMP3	Vesicle associated membrane protein 3. (100 aa)
	TCIRG1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (559 aa)
	SYT7	SYT7 isoform 1. (400 aa)
	RAB38	RAB38, member RAS oncogene family. (211 aa)
	RAB39A	RAB39A, member RAS oncogene family. (217 aa)
	CLEC4E	CLEC4E isoform 1. (219 aa)
	APPL2	APPL2 isoform 1. (564 aa)
	HVCN1	Hydrogen voltage gated channel 1. (275 aa)
	ATP6V0A2	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
	RAB20	RAB20, member RAS oncogene family. (234 aa)
	PIP4P1	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (277 aa)
	SNAP23	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
	ATP6V0C	V-type H+-transporting ATPase 16kDa proteolipid subunit. (128 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (445 aa)
	STX4	STX4 isoform 4; Belongs to the syntaxin family. (296 aa)
	ENSPPYP00000008618	annotation not available (118 aa)
	ENSPPYP00000008720	annotation not available (160 aa)
	RILP	RILP isoform 2. (400 aa)
	RAB34	RAB34 isoform 8. (251 aa)
	RAB31	RAB31, member RAS oncogene family. (195 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
	RAB11B	RAB11B, member RAS oncogene family. (218 aa)
	DNM2	DNM2 isoform 6; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (866 aa)
	CALR	Calreticulin. (417 aa)
	RAB8A	Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] (207 aa)
	RAB22A	RAB22A, member RAS oncogene family. (194 aa)
	RAC2	Rac family small GTPase 2. (192 aa)
	RAB10	Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (By similarity). Regulates, for instance, SLC [...] (199 aa)
	PIKFYVE	PIKFYVE isoform 1. (2088 aa)
	SLC11A1	SLC11A1 isoform 1. (509 aa)
	RAB7A	Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (208 aa)
	RAB5A	RAB5A, member RAS oncogene family. (215 aa)
	TLR1	Toll like receptor 1; Belongs to the Toll-like receptor family. (786 aa)
	TLR6	Toll-like receptor. (796 aa)
	ANXA3	Annexin. (323 aa)
	TLR2	Toll-like receptor. (783 aa)
	HLA-A	Popy Class I histocompatibility antigen, A-1 alpha chain. (365 aa)
	RAB23	RAB23, member RAS oncogene family. (237 aa)
	RAB32	RAB32, member RAS oncogene family. (225 aa)
	CR201_G0055889	Ig-like domain-containing protein; Belongs to the MHC class I family. (362 aa)
	MHC-Poab-B	MHC class I antigen; Belongs to the MHC class I family. (323 aa)
	CR201_G0042422	HLA-G isoform 2; Belongs to the MHC class I family. (365 aa)
	TAPBP	TAPBP isoform 1. (448 aa)
	CR201_G0055693	HLA-B isoform 1; Belongs to the MHC class I family. (362 aa)
	ATP6V0A4	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (876 aa)
	RAB11FIP1	RAB11 family interacting protein 1. (1275 aa)
	PIP4P2	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (278 aa)
	CYBB	Cytochrome b-245 beta chain. (570 aa)
	ATP7A	ATPase copper transporting alpha. (1500 aa)
	RAB9B	Ras-related protein Rab-9B; Involved in the transport of proteins between the endosomes and the trans Golgi network. (201 aa)
	LAMP2	Lysosomal associated membrane protein 2. (410 aa)
	OCRL	OCRL isoform 3. (855 aa)
	VAMP7	Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] (220 aa)
	RAB8B	Ras-related protein Rab-8B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity). (207 aa)

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA3	STX4	ENSPPYP00000016606	ENSPPYP00000008249	Annexin.	STX4 isoform 4; Belongs to the syntaxin family.	0.414
APPL2	ENSPPYP00000008720	ENSPPYP00000005592	ENSPPYP00000008720	APPL2 isoform 1.	annotation not available	0.788
APPL2	RAB11B	ENSPPYP00000005592	ENSPPYP00000010662	APPL2 isoform 1.	RAB11B, member RAS oncogene family.	0.536
APPL2	RAB20	ENSPPYP00000005592	ENSPPYP00000006270	APPL2 isoform 1.	RAB20, member RAS oncogene family.	0.788
APPL2	RAB22A	ENSPPYP00000005592	ENSPPYP00000012479	APPL2 isoform 1.	RAB22A, member RAS oncogene family.	0.788
APPL2	RAB31	ENSPPYP00000005592	ENSPPYP00000010107	APPL2 isoform 1.	RAB31, member RAS oncogene family.	0.788
APPL2	RAB5A	ENSPPYP00000005592	ENSPPYP00000015744	APPL2 isoform 1.	RAB5A, member RAS oncogene family.	0.805
ATP6V0A2	ATP6V0A4	ENSPPYP00000005803	ENSPPYP00000020242	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.992
ATP6V0A2	ATP6V0B	ENSPPYP00000005803	ENSPPYP00000001666	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	ATP6V0B isoform 3; Belongs to the V-ATPase proteolipid subunit family.	0.994
ATP6V0A2	ATP6V0C	ENSPPYP00000005803	ENSPPYP00000007925	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type H+-transporting ATPase 16kDa proteolipid subunit.	0.996
ATP6V0A2	TCIRG1	ENSPPYP00000005803	ENSPPYP00000003450	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.991
ATP6V0A4	ATP6V0A2	ENSPPYP00000020242	ENSPPYP00000005803	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.992
ATP6V0A4	ATP6V0B	ENSPPYP00000020242	ENSPPYP00000001666	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	ATP6V0B isoform 3; Belongs to the V-ATPase proteolipid subunit family.	0.996
ATP6V0A4	ATP6V0C	ENSPPYP00000020242	ENSPPYP00000007925	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type H+-transporting ATPase 16kDa proteolipid subunit.	0.998
ATP6V0A4	TCIRG1	ENSPPYP00000020242	ENSPPYP00000003450	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.992
ATP6V0B	ATP6V0A2	ENSPPYP00000001666	ENSPPYP00000005803	ATP6V0B isoform 3; Belongs to the V-ATPase proteolipid subunit family.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.994
ATP6V0B	ATP6V0A4	ENSPPYP00000001666	ENSPPYP00000020242	ATP6V0B isoform 3; Belongs to the V-ATPase proteolipid subunit family.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.996
ATP6V0B	ATP6V0C	ENSPPYP00000001666	ENSPPYP00000007925	ATP6V0B isoform 3; Belongs to the V-ATPase proteolipid subunit family.	V-type H+-transporting ATPase 16kDa proteolipid subunit.	0.999
ATP6V0B	CORO1A	ENSPPYP00000001666	ENSPPYP00000008183	ATP6V0B isoform 3; Belongs to the V-ATPase proteolipid subunit family.	Coronin; Belongs to the WD repeat coronin family.	0.482
ATP6V0B	TCIRG1	ENSPPYP00000001666	ENSPPYP00000003450	ATP6V0B isoform 3; Belongs to the V-ATPase proteolipid subunit family.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.998