(57 nodes) Midbrain development network (Pongo abelii)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (385 aa)
	ZNF430	ZNF430 isoform 1. (570 aa)
	ENSPPYP00000024179	14-3-3 protein epsilon-like isoform X1. (173 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1000 aa)
	G6PD	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (543 aa)
	TAF1	Transcription initiation factor TFIID subunit. (1755 aa)
	MAOB	Amine oxidase [flavin-containing] B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity). (529 aa)
	SEC16A	Protein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. (2328 aa)
	BARHL1	BARHL1 isoform 1. (172 aa)
	FZD6	Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (706 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (460 aa)
	EN2	Homeobox protein engrailed-like. (335 aa)
	KDM7A	KDM7A isoform 1. (875 aa)
	WNT2	Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
	FZD1	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (649 aa)
	ENSPPYP00000019656	annotation not available (239 aa)
	TFAP2D	Transcription factor AP-2 delta. (452 aa)
	TTBK1	TTBK1 isoform 1. (1323 aa)
	NDST1	N-deacetylase and N-sulfotransferase 1. (882 aa)
	UQCRQ	Cytochrome b-c1 complex subunit 8; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inn [...] (82 aa)
	BASP1	Brain abundant membrane attached signal protein 1. (227 aa)
	SMAD1	Mothers against decapentaplegic homolog. (73 aa)
	ENSPPYP00000016868	annotation not available (85 aa)
	MSX1	MSX1 isoform 1. (261 aa)
	HES1	HES1 isoform 1. (198 aa)
	RYK	RYK isoform 3. (535 aa)
	CTNNB1	CTNNB1 isoform 2. (781 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (473 aa)
	CCDC14	CCDC14 isoform 1. (753 aa)
	EN1	Homeobox protein engrailed-like. (342 aa)
	GDF7	GDF7 isoform 1. (447 aa)
	SOS1	SOS1 isoform 2. (1290 aa)
	OTX1	Orthodenticle homeobox 1. (354 aa)
	YWHAH	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
	CKM	CKM isoform 1; Belongs to the ATP:guanido phosphotransferase family. (360 aa)
	MAG	MAG isoform 1. (627 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
	ENO3	ENO3 isoform 15. (443 aa)
	YWHAE	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
	SYNGR3	Synaptogyrin. (196 aa)
	FOXB1	FOXB1 isoform 1. (325 aa)
	OTX2	OTX2 isoform 1. (275 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	KDM2B	KDM2B isoform 3. (1280 aa)
	DYNLL1	Dynein light chain. (89 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	CASP5	CASP5 isoform 2; Belongs to the peptidase C14A family. (444 aa)
	PHOX2A	Paired like homeobox 2A. (284 aa)
	FGFR2	Fibroblast growth factor receptor. (656 aa)
	PITX3	Homeobox protein. (302 aa)
	DLG5	DLG5 isoform 1; Belongs to the MAGUK family. (1809 aa)
	PADI2	Peptidyl arginine deiminase 2. (665 aa)
	CDC42	Cell division cycle 42. (191 aa)
	SYPL2	Synaptophysin like 2. (272 aa)
	UCHL5	Ubiquitin carboxyl-terminal hydrolase. (396 aa)

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	CTNNB1	ENSPPYP00000002031	ENSPPYP00000015644	Cell division cycle 42.	CTNNB1 isoform 2.	0.794
CDC42	DLG5	ENSPPYP00000002031	ENSPPYP00000002681	Cell division cycle 42.	DLG5 isoform 1; Belongs to the MAGUK family.	0.443
CDC42	FGFR2	ENSPPYP00000002031	ENSPPYP00000003165	Cell division cycle 42.	Fibroblast growth factor receptor.	0.413
CDC42	SOS1	ENSPPYP00000002031	ENSPPYP00000013933	Cell division cycle 42.	SOS1 isoform 2.	0.564
CDC42	YWHAH	ENSPPYP00000002031	ENSPPYP00000013101	Cell division cycle 42.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family.	0.453
CTNNB1	CDC42	ENSPPYP00000015644	ENSPPYP00000002031	CTNNB1 isoform 2.	Cell division cycle 42.	0.794
CTNNB1	DLG5	ENSPPYP00000015644	ENSPPYP00000002681	CTNNB1 isoform 2.	DLG5 isoform 1; Belongs to the MAGUK family.	0.502
CTNNB1	ENSPPYP00000016868	ENSPPYP00000015644	ENSPPYP00000016868	CTNNB1 isoform 2.	annotation not available	0.449
CTNNB1	ENSPPYP00000019656	ENSPPYP00000015644	ENSPPYP00000019656	CTNNB1 isoform 2.	annotation not available	0.498
CTNNB1	ENSPPYP00000024179	ENSPPYP00000015644	ENSPPYP00000024179	CTNNB1 isoform 2.	14-3-3 protein epsilon-like isoform X1.	0.498
CTNNB1	FGF9	ENSPPYP00000015644	ENSPPYP00000005926	CTNNB1 isoform 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.499
CTNNB1	FGFR2	ENSPPYP00000015644	ENSPPYP00000003165	CTNNB1 isoform 2.	Fibroblast growth factor receptor.	0.606
CTNNB1	FZD1	ENSPPYP00000015644	ENSPPYP00000019980	CTNNB1 isoform 2.	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	0.711
CTNNB1	FZD3	ENSPPYP00000015644	ENSPPYP00000020708	CTNNB1 isoform 2.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.631
CTNNB1	FZD6	ENSPPYP00000015644	ENSPPYP00000021096	CTNNB1 isoform 2.	Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...]	0.541
CTNNB1	LRP6	ENSPPYP00000015644	ENSPPYP00000024153	CTNNB1 isoform 2.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.910
CTNNB1	RYK	ENSPPYP00000015644	ENSPPYP00000015796	CTNNB1 isoform 2.	RYK isoform 3.	0.456
CTNNB1	SHH	ENSPPYP00000015644	ENSPPYP00000020423	CTNNB1 isoform 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.677
CTNNB1	SMAD1	ENSPPYP00000015644	ENSPPYP00000016869	CTNNB1 isoform 2.	Mothers against decapentaplegic homolog.	0.449
CTNNB1	WNT1	ENSPPYP00000015644	ENSPPYP00000005109	CTNNB1 isoform 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.842