STRINGSTRING
PTF1A PTF1A ILDR2 ILDR2 NR5A2 NR5A2 PROX1 PROX1 CR201_G0047764 CR201_G0047764 CR201_G0016264 CR201_G0016264 BMP5 BMP5 NEUROG3 NEUROG3 CR201_G0012836 CR201_G0012836 NKX6-2 NKX6-2 IGF2 IGF2 RBM4 RBM4 MEN1 MEN1 PAX6 PAX6 SIDT2 SIDT2 ENSPPYP00000005166 ENSPPYP00000005166 CR201_G0000883 CR201_G0000883 PDX1 PDX1 BAK1 BAK1 SRP54 SRP54 BMP4 BMP4 MEIS2 MEIS2 ONECUT1 ONECUT1 ALDH1A2 ALDH1A2 CR201_G0054877 CR201_G0054877 PDPK1 PDPK1 CR201_G0036821 CR201_G0036821 FOXF1 FOXF1 HNF1B HNF1B SOX9 SOX9 CCDC40 CCDC40 GIP GIP GATA6 GATA6 CDH2 CDH2 SMAD2 SMAD2 ONECUT2 ONECUT2 INSR INSR GIPR GIPR NKX2-2 NKX2-2 CR201_G0019832 CR201_G0019832 HNF4A HNF4A EIF2AK3 EIF2AK3 IHH IHH WNT5A WNT5A CTNNB1 CTNNB1 ACVR2B ACVR2B CCDC39 CCDC39 HES1 HES1 WFS1 WFS1 NKX3-2 NKX3-2 NKX6-1 NKX6-1 FGF10 FGF10 ISL1 ISL1 PCSK1 PCSK1 BMP6 BMP6 RFX6 RFX6 DLL1 DLL1 BHLHA15 BHLHA15 IL6 IL6 CDK6 CDK6 PAX4 PAX4 SMO SMO SHH SHH MNX1 MNX1 RFX3 RFX3 ZIC3 ZIC3 NEUROD1 NEUROD1 IL6R IL6R SELENOT SELENOT CR201_G0011157 CR201_G0011157 GDF11 GDF11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTF1APTF1A isoform 1. (422 aa)
ILDR2ILDR2 isoform 9. (640 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2. (541 aa)
PROX1Prospero homeobox 1. (737 aa)
CR201_G0047764Transcription factor SOX. (308 aa)
CR201_G0016264BAK1 isoform 3. (172 aa)
BMP5BMP5 isoform 1. (453 aa)
NEUROG3NEUROG3 isoform 1. (214 aa)
CR201_G0012836TCF7L2 isoform 2. (430 aa)
NKX6-2NKX6-2 isoform 2. (277 aa)
IGF2Insulin-like growth factor II. (180 aa)
RBM4RBM4 isoform 12. (361 aa)
MEN1MEN1 isoform 1. (610 aa)
PAX6PAX6 isoform 13. (266 aa)
SIDT2SIDT2 isoform 3. (776 aa)
ENSPPYP00000005166annotation not available (176 aa)
CR201_G0000883HNF1A isoform 7. (347 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
BAK1Bcl-2 homologous antagonist/killer. (147 aa)
SRP54Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein); Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MEIS2MEIS2 isoform 15. (394 aa)
ONECUT1One cut domain family member. (465 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
CR201_G0054877MSLN isoform 7. (454 aa)
PDPK1PDPK1 isoform 1. (495 aa)
CR201_G0036821Dynein assembly factor 1, axonemal. (670 aa)
FOXF1FOXF1 isoform 1. (380 aa)
HNF1BHepatocyte nuclear factor 1-beta; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. (557 aa)
SOX9SRY-box transcription factor 9. (509 aa)
CCDC40CCDC40 isoform 3. (1140 aa)
GIPGIP isoform 1. (124 aa)
GATA6GATA6 isoform 1. (580 aa)
CDH2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic s [...] (906 aa)
SMAD2Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] (467 aa)
ONECUT2One cut domain family member. (472 aa)
INSRTyrosine-protein kinase receptor. (1305 aa)
GIPRGIPR isoform 4; Belongs to the G-protein coupled receptor 2 family. (429 aa)
NKX2-2NKX2-2 isoform 1. (273 aa)
CR201_G0019832T0068022 isoform 1. (302 aa)
HNF4AHNF4A isoform 1. (462 aa)
EIF2AK3EIF2AK3 isoform 1. (1116 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (473 aa)
CTNNB1CTNNB1 isoform 2. (781 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
CCDC39CCDC39 isoform 3. (753 aa)
HES1HES1 isoform 1. (198 aa)
WFS1WFS1 isoform 1. (964 aa)
NKX3-2NKX3-2 isoform 1. (333 aa)
NKX6-1NKX6-1 isoform 2. (367 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ISL1ISL1 isoform 1. (349 aa)
PCSK1PCSK1 isoform 1; Belongs to the peptidase S8 family. (753 aa)
BMP6BMP6 isoform 1. (510 aa)
RFX6RFX6 isoform 1. (925 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
BHLHA15Basic helix-loop-helix family member a15. (190 aa)
IL6IL6 isoform 2. (212 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
PAX4PAX4 isoform 1. (351 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (460 aa)
MNX1MNX1 isoform 4. (363 aa)
RFX3Regulatory factor X3. (707 aa)
ZIC3Zic family member 3. (466 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
IL6RIL6R isoform 2. (499 aa)
SELENOTSelenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (137 aa)
CR201_G0011157PAX6 isoform 63. (257 aa)
GDF11GDF11 isoform 2. (263 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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