Your Input: | |
| | MAD2L1 | MAD2L1 isoform 1. (300 aa) |
| | TNFAIP3 | TNFAIP3 isoform 1. (790 aa) |
| | ENSPPYP00000018959 | annotation not available (315 aa) |
| | FYN | Tyrosine-protein kinase. (537 aa) |
| | ATG5 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] (275 aa) |
| | UFL1 | UFL1 isoform 2. (773 aa) |
| | BAG2 | BCL2 associated athanogene 2. (211 aa) |
| | GCLC | Glutamate-cysteine ligase catalytic subunit. (637 aa) |
| | HSP90AB1 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] (724 aa) |
| | ENSPPYP00000018534 | annotation not available (72 aa) |
| | CR201_G0047764 | Transcription factor SOX. (308 aa) |
| | NHLRC1 | NHL repeat containing E3 ubiquitin protein ligase 1. (395 aa) |
| | TBC1D7 | TBC1 domain family member 7. (293 aa) |
| | FOXF2 | FOXF2 isoform 1. (184 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | SQSTM1 | Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and [...] (436 aa) |
| | PRR7 | Proline rich 7, synaptic. (274 aa) |
| | NPM1 | NPM1 isoform 1. (274 aa) |
| | SH3RF2 | SH3 domain containing ring finger 2. (729 aa) |
| | NDFIP1 | Nedd4 family interacting protein 1. (221 aa) |
| | HDAC3 | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activi [...] (428 aa) |
| | CAMLG | Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (299 aa) |
| | SKP1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa) |
| | ARRDC3 | Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes. (413 aa) |
| | RNF180 | E3 ubiquitin-protein ligase RNF180; E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2. (579 aa) |
| | CDC20B | CDC20B isoform 4. (518 aa) |
| | FBXO4 | FBXO4 isoform 2. (387 aa) |
| | CR201_G0022133 | RASSF5 isoform 7. (330 aa) |
| | INAVA | INAVA isoform 1. (577 aa) |
| | TTC36 | Tetratricopeptide repeat domain 36. (189 aa) |
| | GABARAPL1 | Gamma-aminobutyric acid receptor-associated protein-like 1. (85 aa) |
| | PRICKLE1 | Prickle planar cell polarity protein 1. (831 aa) |
| | USP44 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (713 aa) |
| | CRY1 | Cryptochrome circadian regulator 1. (586 aa) |
| | LOC100449224 | RPS2 isoform 1; Belongs to the universal ribosomal protein uS5 family. (293 aa) |
| | NDFIP2 | NDFIP2 isoform 1. (242 aa) |
| | DCUN1D2 | DCN1-like protein. (244 aa) |
| | FBXO33 | F-box protein 33. (555 aa) |
| | FANCM | FANCM isoform 2. (1942 aa) |
| | RPL37 | Ribosomal protein L37; Binds to the 23S rRNA. (97 aa) |
| | SKP2 | SKP2 isoform 1. (410 aa) |
| | PDCD6 | Programmed cell death protein 6 isoform X1. (191 aa) |
| | FBXW7 | FBXW7 isoform 8. (627 aa) |
| | SASH1 | SASH1 isoform 2. (1192 aa) |
| | RCHY1 | Ring finger and CHY zinc finger domain containing 1. (261 aa) |
| | DCUN1D4 | DCN1-like protein. (292 aa) |
| | ENSPPYP00000016309 | annotation not available (193 aa) |
| | WFS1 | WFS1 isoform 1. (964 aa) |
| | SIAH2 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa) |
| | SPSB4 | SplA/ryanodine receptor domain and SOCS box containing 4. (273 aa) |
| | USP4 | Ubiquitin carboxyl-terminal hydrolase 4; Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins. Deubiquitinates PDPK1. Deubiquitinates TRIM21. Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER. (735 aa) |
| | RASSF1 | RASSF1 isoform 4. (304 aa) |
| | CBLB | Cbl proto-oncogene B. (982 aa) |
| | DTX3L | DTX3L isoform 1. (708 aa) |
| | PER2 | PER2 isoform 2. (1226 aa) |
| | TRIP12 | TRIP12 isoform 4. (2039 aa) |
| | CUL3 | CUL3 isoform 1; Belongs to the cullin family. (768 aa) |
| | DNAJB2 | DNAJB2 isoform 1. (298 aa) |
| | ENSPPYP00000014644 | annotation not available (149 aa) |
| | ENSPPYP00000014638 | annotation not available (242 aa) |
| | MARCHF7 | E3 ubiquitin-protein ligase MARCHF7; E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (By similarity). (704 aa) |
| | NMI | NMI isoform 1. (307 aa) |
| | SPOPL | Speckle type BTB/POZ protein like. (392 aa) |
| | WASHC1 | WAS protein family homolog 1. (467 aa) |
| | UBXN2A | UBXN2A isoform 2. (261 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) |
| | CR201_G0003257 | COMMD1 isoform 4. (146 aa) |
| | PELI1 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa) |
| | TSPO | Translocator protein. (169 aa) |
| | ENSPPYP00000013283 | annotation not available (297 aa) |
| | RBX1 | RBX1 isoform 1. (108 aa) |
| | ENSPPYP00000012887 | annotation not available (62 aa) |
| | PTTG1IP | Pituitary tumor-transforming gene 1 protein-interacting protein; May facilitate PTTG1 nuclear translocation. (91 aa) |
| | BIRC7 | Baculoviral IAP repeat containing 7. (280 aa) |
| | UBE2C | Ubiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) |
| | TRIB3 | TRIB3 isoform 1. (358 aa) |
| | ENSPPYP00000012086 | annotation not available (110 aa) |
| | SPRTN | SPRTN isoform 1. (385 aa) |
| | LOC100440082 | RPS2 isoform 12; Belongs to the universal ribosomal protein uS5 family. (293 aa) |
| | U2AF2 | U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family. (356 aa) |
| | UBE2S | UBE2S isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (222 aa) |
| | HSPBP1 | HSPBP1 isoform 1. (240 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (692 aa) |
| | GSK3A | Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa) |
| | ENSPPYP00000010984 | annotation not available (156 aa) |
| | FBXW9 | F-box and WD repeat domain containing 9. (458 aa) |
| | PIN1 | Peptidyl-prolyl cis-trans isomerase. (163 aa) |
| | FZR1 | FZR1 isoform 4. (420 aa) |
| | MALT1 | MALT1 isoform 1. (774 aa) |
| | SMAD7 | Mothers against decapentaplegic homolog. (426 aa) |
| | ENSPPYP00000010097 | annotation not available (194 aa) |
| | CDK5RAP3 | CDK5 regulatory subunit-associated protein 3; Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation. Negatively regulates NF- kappa-B-mediated gene transcription through the control of RELA phosphorylation. Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation. May play a role in the unfol [...] (506 aa) |
| | ENSPPYP00000009921 | annotation not available (293 aa) |
| | SIRT7 | SIRT7 isoform 2. (195 aa) |
| | SPHK1 | SPHK1 isoform 7. (470 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1863 aa) |
| | GABARAP | Gamma-aminobutyric acid receptor-associated protein-like 1; Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity); Belongs to the ATG8 family. (117 aa) |
| | CR201_G0048121 | PHF23 isoform 2. (264 aa) |
| | NXN | NXN isoform 1. (390 aa) |
| | PABPN1L | PABPN1L isoform 3. (277 aa) |
| | NOD2 | NOD2 isoform 4. (1040 aa) |
| | N4BP1 | N4BP1 isoform 1. (894 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (603 aa) |
| | DNAJA3 | DNAJA3 isoform 2. (464 aa) |
| | CR201_G0055545-2 | RPS2 isoform 9; Belongs to the universal ribosomal protein uS5 family. (284 aa) |
| | STUB1 | STIP1 homology and U-box containing protein 1. (303 aa) |
| | CR201_G0054585 | AXIN1 isoform 6. (551 aa) |
| | ARRDC4 | Arrestin domain containing 4. (418 aa) |
| | LOC100445631 | GABARAPL1 isoform 2. (113 aa) |
| | FANCI | FANCI isoform 2. (1328 aa) |
| | LOC100446892 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (165 aa) |
| | PSEN1 | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (463 aa) |
| | CR201_G0033998 | CCDC197 isoform 1. (143 aa) |
| | OTUB2 | OTUB2 isoform 1. (238 aa) |
| | BAG5 | BCL2 associated athanogene 5. (447 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (413 aa) |
| | MTA1 | MTA1 isoform 4. (697 aa) |
| | UBE3A | Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (849 aa) |
| | BUB1B | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. (1050 aa) |
| | CHP1 | Calcineurin B homologous protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane- type Na(+)/H(+) ex [...] (195 aa) |
| | RNF111 | E3 ubiquitin-protein ligase Arkadia; E3 ubiquitin-protein ligase (By similarity). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (By similarity). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by med [...] (984 aa) |
| | MINAR1 | Membrane integral NOTCH2 associated receptor 1. (854 aa) |
| | CR201_G0027499 | ABL1 isoform 3. (48 aa) |
| | ABL1 | Tyrosine-protein kinase. (948 aa) |
| | ENSPPYP00000022319 | annotation not available (162 aa) |
| | DDX3X | ATP-dependent RNA helicase DDX3Y; Probable ATP-dependent RNA helicase. May play a role in spermatogenesis (By similarity); Belongs to the DEAD box helicase family. DDX3/DED1 subfamily. (662 aa) |
| | ENSPPYP00000022712 | annotation not available (241 aa) |
| | HUWE1 | HUWE1 isoform 1. (4373 aa) |
| | GNL3L | GNL3L isoform 1. (577 aa) |
| | AMER1 | APC membrane recruitment protein 1. (1136 aa) |
| | TAF1 | Transcription initiation factor TFIID subunit. (1755 aa) |
| | OGT | OGT isoform 1. (1045 aa) |
| | PSMD10 | Proteasome 26S subunit, non-ATPase 10. (226 aa) |
| | XIAP | XIAP isoform 2. (513 aa) |
| | CR201_G0046490 | MAGEA3 isoform 1. (314 aa) |
| | RPS7 | 40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa) |
| | ENSPPYP00000023631 | annotation not available (214 aa) |
| | ENSPPYP00000023667 | annotation not available (104 aa) |
| | LRRK2 | LRRK2 isoform 3. (1560 aa) |
| | MYCBP2 | MYCBP2 isoform 1. (3875 aa) |
| | EPM2A | EPM2A glucan phosphatase, laforin. (331 aa) |
| | CR201_G0028599 | SPRTN isoform 5. (111 aa) |
| | DCUN1D1 | DCN1-like protein. (162 aa) |
| | ENSPPYP00000024654 | annotation not available (172 aa) |
| | RPL5 | Ribosomal protein L5. (297 aa) |
| | GLMN | Glomulin, FKBP associated protein. (594 aa) |
| | CR201_G0055545 | RPS2 isoform 6; Belongs to the universal ribosomal protein uS5 family. (245 aa) |
| | BCL10 | BCL10 isoform 1. (263 aa) |
| | CDC20 | Cell division cycle 20. (499 aa) |
| | SVBP | Small vasohibin binding protein. (66 aa) |
| | PEF1 | Penta-EF-hand domain containing 1. (284 aa) |
| | KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa) |
| | PINK1 | PTEN induced kinase 1. (581 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (211 aa) |
| | FBXO2 | F-box protein 2. (295 aa) |
| | PARK7 | PARK7 isoform 1. (189 aa) |
| | ISG15 | ISG15 ubiquitin like modifier. (165 aa) |
| | GTPBP4 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (634 aa) |
| | IVNS1ABP | Influenza virus NS1A binding protein. (642 aa) |
| | PTPN22 | Protein tyrosine phosphatase non-receptor type 22. (807 aa) |
| | BIRC2 | Baculoviral IAP repeat containing 2. (597 aa) |
| | RPS3 | 40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8- dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] (243 aa) |
| | ARRB1 | ARRB1 isoform 2. (473 aa) |
| | PRMT3 | PRMT3 isoform 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (551 aa) |
| | TRIM44 | Tripartite motif-containing protein 44; May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17 (By similarity). Is a negative regulator of PAX6 expression (By similarity). (344 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (604 aa) |
| | UBXN1 | UBXN1 isoform 1. (296 aa) |
| | OTUB1 | Ubiquitin thioesterase OTUB1 isoform X1. (270 aa) |
| | ENSPPYP00000003305 | annotation not available (159 aa) |
| | WBP1L | WW domain binding protein 1 like. (363 aa) |
| | BTRC | BTRC isoform 2. (605 aa) |
| | PTEN | Pongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | UBE2D1 | Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | MASTL | MASTL isoform 1. (878 aa) |
| | BMI1 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...] (326 aa) |
| | HSPA5 | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (654 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa) |
| | CDC14B | Cell division cycle 14B. (498 aa) |
| | UBQLN1 | Ubiquilin-1; Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin- proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a lin [...] (577 aa) |
| | CR201_G0001895 | CDKN2A isoform 2. (173 aa) |
| | PLAA | PLAA isoform 1. (869 aa) |
| | VPS28 | Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (205 aa) |
| | PARP10 | Poly [ADP-ribose] polymerase. (975 aa) |
| | ADGRB1 | ADGRB1 isoform 2. (1512 aa) |
| | DERL1 | Derlin-1; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress-induced pre- emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for pro [...] (201 aa) |
| | MTBP | MTBP isoform 3. (515 aa) |
| | ANGPT1 | ANGPT1 isoform 2. (498 aa) |
| | ENSPPYP00000021091 | annotation not available (270 aa) |
| | UBR5 | UBR5 isoform 1. (2695 aa) |
| | TSPYL5 | TSPYL5 isoform 1; Belongs to the nucleosome assembly protein (NAP) family. (414 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | ENSPPYP00000020880 | annotation not available (223 aa) |
| | UBE2V2 | Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity); Belongs to the ubiquitin-c [...] (145 aa) |
| | PINX1 | PIN2/TERF1-interacting telomerase inhibitor 1. (329 aa) |
| | PAXIP1 | PAX interacting protein 1. (1071 aa) |
| | CDK5 | Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa) |
| | ENSPPYP00000020360 | annotation not available (272 aa) |
| | CAV1 | Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...] (178 aa) |
| | ENSPPYP00000020088 | annotation not available (138 aa) |
| | CR201_G0040641 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (143 aa) |
| | PPIA | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (306 aa) |
| | ENSPPYP00000019653 | annotation not available (293 aa) |
| | LIMK1 | LIMK1 isoform 2. (468 aa) |
| | AIMP2 | Aminoacyl tRNA synthetase complex interacting multifunctional protein 2. (320 aa) |
| | DAXX | Death domain associated protein. (743 aa) |
| | CR201_G0036895 | PRKN isoform 8. (335 aa) |
