Your Input: | |
| | NSG2 | Neuronal vesicle trafficking associated 2. (171 aa) |
| | BAIAP3 | BAIAP3 isoform 3. (1072 aa) |
| | VPS33B | VPS33B isoform 1; Belongs to the STXBP/unc-18/SEC1 family. (617 aa) |
| | STOML1 | STOML1 isoform 1. (398 aa) |
| | VPS13C | VPS13C isoform 1. (3448 aa) |
| | ANXA2 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family. (339 aa) |
| | RAB27A | RAB27A, member RAS oncogene family. (221 aa) |
| | SPPL2A | Signal peptide peptidase like 2A. (520 aa) |
| | ENSPPYP00000007304 | annotation not available (318 aa) |
| | VPS39 | VPS39 isoform 1. (875 aa) |
| | VPS18 | VPS18 core subunit of CORVET and HOPS complexes. (973 aa) |
| | VTI1B | Vesicle transport through interaction with t-SNAREs 1B. (232 aa) |
| | AP5M1 | Adaptor related protein complex 5 subunit mu 1; Belongs to the adaptor complexes medium subunit family. (490 aa) |
| | CHMP4A | CHMP4A isoform 4. (258 aa) |
| | PIP4P1 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (277 aa) |
| | LAMP1 | LAMP1 isoform 1. (368 aa) |
| | NDFIP2 | NDFIP2 isoform 1. (242 aa) |
| | VPS37B | VPS37B isoform 1. (285 aa) |
| | VPS33A | T0002578 isoform 1; Belongs to the STXBP/unc-18/SEC1 family. (596 aa) |
| | PMEL | PMEL isoform 9. (574 aa) |
| | CD63 | Tetraspanin. (238 aa) |
| | SORL1 | SORL1 isoform 1. (2118 aa) |
| | VPS11 | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (941 aa) |
| | LAMTOR1 | Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulat [...] (161 aa) |
| | TSG101 | TSG101 isoform 4. (352 aa) |
| | VPS37C | Vacuolar protein sorting-associated protein 37C; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation (By similarity); Belongs to the VPS37 family. (355 aa) |
| | CYB561A3 | Cytochrome b561 family member A3. (242 aa) |
| | CR201_G0031594 | TPCN2 isoform 7. (717 aa) |
| | VTI1A | Vesicle transport through interaction with t-SNAREs 1A. (217 aa) |
| | TSPAN15 | Tetraspanin. (294 aa) |
| | SLC29A3 | Solute carrier family 29 member 3. (475 aa) |
| | LOC100433557 | Annexin. (327 aa) |
| | MARCHF8 | MARCH8 isoform 2. (291 aa) |
| | CLCN6 | CLCN6 isoform 2; Belongs to the chloride channel (TC 2.A.49) family. (824 aa) |
| | ATP13A2 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1175 aa) |
| | OSBPL9 | Oxysterol-binding protein-related protein 9; Belongs to the OSBP family. (736 aa) |
| | YIPF1 | Protein YIPF1; Belongs to the YIP1 family. (306 aa) |
| | TMEM59 | Transmembrane protein 59; Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. (323 aa) |
| | MCOLN2 | MCOLN2 isoform 1. (532 aa) |
| | MCOLN3 | MCOLN3 isoform 4. (553 aa) |
| | KIAA1324 | KIAA1324 isoform 4. (1013 aa) |
| | LAMTOR5 | LAMTOR5 isoform 1. (182 aa) |
| | LAMTOR2 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa) |
| | NTRK1 | Tyrosine-protein kinase receptor. (796 aa) |
| | MR1 | Major histocompatibility complex class I-related gene protein; Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T- cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent (By similarity). (340 aa) |
| | TMEM9 | Transmembrane protein 9. (183 aa) |
| | ARL8A | ADP ribosylation factor like GTPase 8A; Belongs to the small GTPase superfamily. Arf family. (186 aa) |
| | TMEM165 | GDT1 family protein. (324 aa) |
| | SCARB2 | SCARB2 isoform 16; Belongs to the CD36 family. (478 aa) |
| | LAMTOR3 | Ragulator complex protein LAMTOR3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] (124 aa) |
| | MARCHF1 | MARCH1 isoform 2. (542 aa) |
| | CLCN3 | H(+)/Cl(-) exchange transporter 3; Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory (By similarity). (866 aa) |
| | SLC38A9 | SLC38A9 isoform 14. (541 aa) |
| | ANXA6 | Annexin. (660 aa) |
| | ATP10B | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1460 aa) |
| | ABCA3 | ABCA3 isoform 1. (1595 aa) |
| | HLA-DRB5 | Ig-like domain-containing protein. (266 aa) |
| | FIG4 | FIG4 isoform 1. (891 aa) |
| | CD68 | CD68 isoform 1. (354 aa) |
| | STX8 | STX8 isoform 2. (236 aa) |
| | MMD | MMD isoform 1. (118 aa) |
| | GOSR2 | T0082108 isoform 1; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (212 aa) |
| | PLEKHM1 | PLEKHM1 isoform 1. (564 aa) |
| | CR201_G0023764 | PLEKHM1 isoform 4. (241 aa) |
| | CD300LG | CD300LG isoform 5. (233 aa) |
| | STARD3 | STARD3 isoform 16. (438 aa) |
| | ABCA5 | ABCA5 isoform 1. (1622 aa) |
| | CHMP6 | Charged multivesicular body protein 6; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] (178 aa) |
| | CR201_G0021153 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (616 aa) |
| | SNF8 | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (279 aa) |
| | RMC1 | Regulator of MON1-CCZ1. (657 aa) |
| | NPC1 | NPC1 isoform 1. (1243 aa) |
| | RAB27B | RAB27B, member RAS oncogene family. (218 aa) |
| | VPS4B | Vacuolar protein sorting-associated protein 4B; Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth fact [...] (444 aa) |
| | UBXN6 | UBXN6 isoform 3. (436 aa) |
| | YIPF2 | Protein YIPF. (287 aa) |
| | MVB12A | Multivesicular body subunit 12A. (273 aa) |
| | ENSPPYP00000011173 | annotation not available (222 aa) |
| | PLD3 | 5'-3' exonuclease PLD3; 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (By similarity). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity). May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting (By similarity). (490 aa) |
| | CHMP2A | CHMP2A isoform 1. (222 aa) |
| | AP5S1 | Adaptor related protein complex 5 subunit sigma 1. (200 aa) |
| | VPS16 | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (839 aa) |
| | CHMP4B | CHMP4B isoform 1. (210 aa) |
| | CHMP3 | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] (222 aa) |
| | VAMP8 | Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex. Also required for dense-granule secretion in platelets. Plays als [...] (253 aa) |
| | SLC30A3 | Zinc transporter 3; Involved in accumulation of zinc in synaptic vesicles. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. (481 aa) |
| | LAPTM4A | Lysosomal-associated transmembrane protein 4A; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment. (233 aa) |
| | PIKFYVE | PIKFYVE isoform 1. (2088 aa) |
| | MREG | MREG isoform 1. (214 aa) |
| | SLC11A1 | SLC11A1 isoform 1. (509 aa) |
| | ABCB6 | ATP binding cassette subfamily B member 6 (Langereis blood group). (843 aa) |
| | ATG9A | Autophagy-related protein 9A; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H (By similarity). (838 aa) |
| | RAB7A | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (208 aa) |
| | OSBPL11 | Oxysterol-binding protein; Belongs to the OSBP family. (748 aa) |
| | CHMP2B | Charged multivesicular body protein 2b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] (213 aa) |
| | ARL8B | ADP-ribosylation factor-like protein 8B; Plays a role in lysosome motility. In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (By similarity). (185 aa) |
| | ABHD6 | Abhydrolase domain containing 6. (337 aa) |
| | SLC9A9 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (619 aa) |
| | RNF13 | E3 ubiquitin-protein ligase RNF13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. (381 aa) |
| | PLD1 | Phospholipase. (1074 aa) |
| | LAMP3 | Lysosomal associated membrane protein 3. (415 aa) |
| | ATP13A4 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1151 aa) |
| | ATP13A3 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1207 aa) |
| | NSG1 | Neuronal vesicle trafficking-associated protein 1; Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatoden [...] (185 aa) |
| | SLC11A2 | SLC11A2 isoform 12. (573 aa) |
| | VAMP7 | Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] (220 aa) |
| | LAMP2 | Lysosomal associated membrane protein 2. (410 aa) |
| | ENSPPYP00000022952 | annotation not available (197 aa) |
| | CLCN4 | Chloride channel protein. (760 aa) |
| | MITD1 | MIT domain-containing protein. (215 aa) |
| | MVB12B | MVB12B isoform 1. (278 aa) |
| | SLC1A1 | Amino acid transporter. (524 aa) |
| | CHMP5 | Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] (219 aa) |
| | VPS28 | Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (205 aa) |
| | LAPTM4B | LAPTM4B isoform 1. (193 aa) |
| | PIP4P2 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (278 aa) |
| | CHMP4C | Charged multivesicular body protein 4C. (233 aa) |
| | SNX16 | Sorting nexin-16; May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling (By similarity); Belongs to the sorting nexin family. (344 aa) |
| | CHMP7 | Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway. (453 aa) |
| | SLC39A14 | Zinc transporter ZIP14; Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron. (507 aa) |
| | VPS37A | VPS37A subunit of ESCRT-I. (397 aa) |
| | GALNTL5 | GALNTL5 isoform 1. (395 aa) |
| | WDR91 | WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3- phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May play a role in meiosis. (747 aa) |
| | TMEM106B | Transmembrane protein 106B. (274 aa) |
| | STARD3NL | STARD3NL isoform 1. (77 aa) |
| | VPS41 | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (854 aa) |
| | VPS37D | VPS37D isoform 1. (230 aa) |
| | LAMTOR4 | Ragulator complex protein LAMTOR4, N-terminally processed; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity). (99 aa) |
| | MICALL2 | MICALL2 isoform 9. (905 aa) |
| | LOC100460187 | MHC class II protein; Belongs to the MHC class II family. (254 aa) |
| | HLA-DMA | HLA class II histocompatibility antigen, DM alpha chain isoform X1. (261 aa) |
| | LOC100448477 | HLA-DMB isoform 5. (263 aa) |
| | ENSPPYP00000019293 | HLA class II histocompatibility antigen, DRB1-11 beta chain isoform X1. (266 aa) |
| | CR201_G0016191 | HLA-DRB5 isoform 1. (290 aa) |
| | CR201_G0041408 | WDR81 isoform 4. (691 aa) |
| | RILP | RILP isoform 2. (400 aa) |
| | CR201_G0054316 | LITAF isoform 8. (126 aa) |
| | CHMP1A | Charged multivesicular body protein 1a; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] (196 aa) |
| | VAC14 | VAC14 component of PIKFYVE complex. (782 aa) |
| | VPS4A | VPS4A isoform 1; Belongs to the AAA ATPase family. (437 aa) |
| | CLN3 | Battenin. (438 aa) |
| | ENSPPYP00000008037 | annotation not available (125 aa) |
| | CR201_G0047293 | T0166643 isoform 1. (158 aa) |
| | CDIP1 | Cell death inducing p53 target 1. (208 aa) |
