STRINGSTRING
AVPR1B AVPR1B PON1 PON1 EEPD1 EEPD1 ABCA13 ABCA13 TREM2 TREM2 EDN1 EDN1 BMP6 BMP6 PRELID1 PRELID1 DAB2 DAB2 ENSPPYP00000024539 ENSPPYP00000024539 ABCG1 ABCG1 ABCA9 ABCA9 RXRA RXRA PTGES PTGES LIPG LIPG ENPP7 ENPP7 C1QTNF1 C1QTNF1 MAP2K6 MAP2K6 ABCA5 ABCA5 ABCA8 ABCA8 CES4A CES4A CETP CETP CES1 CES1 ENSPPYP00000008314 ENSPPYP00000008314 PLA2G10 PLA2G10 ABCA3 ABCA3 NMB NMB ANXA2 ANXA2 CYP19A1 CYP19A1 NFKBIA NFKBIA CR201_G0055387 CR201_G0055387 TNFRSF11A TNFRSF11A GALR1 GALR1 TNFSF11 TNFSF11 LOC100442324 LOC100442324 P2RX7 P2RX7 TRIAP1 TRIAP1 CR201_G0000874 CR201_G0000874 LRP1 LRP1 DENND5B DENND5B LPCAT3 LPCAT3 ABCG4 ABCG4 APOA1 APOA1 NR1H3 NR1H3 GAL GAL ENSPPYP00000003259 ENSPPYP00000003259 ACSL5 ACSL5 SIRT1 SIRT1 LDLRAP1 LDLRAP1 FABP3 FABP3 SCP2 SCP2 FASLG FASLG PLA2G4A PLA2G4A ABCA1 ABCA1 PTCH1 PTCH1 CRH CRH NKX3-1 NKX3-1 ZDHHC8 ZDHHC8 NTSR1 NTSR1 PLTP PLTP OXT OXT SSTR4 SSTR4 SCP2D1 SCP2D1 NR1H2 NR1H2 CR201_G0037528 CR201_G0037528 RETN RETN ABCA7 ABCA7 C1QTNF6 C1QTNF6 PLA2G6 PLA2G6 ECRG4 ECRG4 IL1A IL1A IL1B IL1B ENSPPYP00000014133 ENSPPYP00000014133 CAV1 CAV1 ABCB4 ABCB4 DBI DBI PLA2R1 PLA2R1 ABCA12 ABCA12 ERFE ERFE PPARG PPARG GHRL GHRL TMF1 TMF1 PRKCD PRKCD CYP8B1 CYP8B1 ADIPOQ ADIPOQ ATP8A1 ATP8A1 LRAT LRAT ACSL1 ACSL1 PLA2G3 PLA2G3 MIF MIF SPP1 SPP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (425 aa)
PON1PON1 isoform 1. (355 aa)
EEPD1Endonuclease/exonuclease/phosphatase family domain containing 1. (569 aa)
ABCA13ABCA13 isoform 2. (4952 aa)
TREM2TREM2 isoform 1. (202 aa)
EDN1EDN1 isoform 1. (212 aa)
BMP6BMP6 isoform 1. (510 aa)
PRELID1PRELI domain containing 1. (219 aa)
DAB2DAB adaptor protein 2. (770 aa)
ENSPPYP00000024539annotation not available (66 aa)
ABCG1ATP binding cassette subfamily G member 1. (677 aa)
ABCA9ABCA9 isoform 1. (1125 aa)
RXRARXRA isoform 2. (456 aa)
PTGESProstaglandin E synthase. (152 aa)
LIPGLipase G, endothelial type. (500 aa)
ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase 7. (458 aa)
C1QTNF1C1QTNF1 isoform 10. (281 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
ABCA5ABCA5 isoform 1. (1622 aa)
ABCA8ABCA8 isoform 1. (1413 aa)
CES4ACarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (442 aa)
CETPCholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (493 aa)
CES1Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (542 aa)
ENSPPYP00000008314Liver carboxylesterase 1-like isoform X1. (246 aa)
PLA2G10PLA2G10 isoform 1. (164 aa)
ABCA3ABCA3 isoform 1. (1595 aa)
NMBNMB isoform 2. (154 aa)
ANXA2Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family. (339 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
NFKBIANFKBIA isoform 1. (317 aa)
CR201_G0055387PhoLip_ATPase_N domain-containing protein. (108 aa)
TNFRSF11ATNFRSF11A isoform 5. (616 aa)
GALR1GALR1 isoform 1; Belongs to the G-protein coupled receptor 1 family. (349 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
LOC100442324Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (725 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
TRIAP1TRIAP1 isoform 1. (91 aa)
CR201_G0000874P2RX7 isoform 7. (101 aa)
LRP1LRP1 isoform 1. (4377 aa)
DENND5BDENND5B isoform 2. (1308 aa)
LPCAT3LPCAT3 isoform 2; Belongs to the membrane-bound acyltransferase family. (487 aa)
ABCG4ATP binding cassette subfamily G member 4. (646 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity). (219 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (447 aa)
GALGalanin and GMAP prepropeptide. (123 aa)
ENSPPYP00000003259annotation not available (98 aa)
ACSL5ACSL5 isoform 4. (705 aa)
SIRT1SIRT1 isoform 1. (746 aa)
LDLRAP1LDLRAP1 isoform 1. (308 aa)
FABP3Fatty acid binding protein 3; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
SCP2SCP2 isoform 1; Belongs to the thiolase-like superfamily. Thiolase family. (547 aa)
FASLGFASLG isoform 1; Belongs to the tumor necrosis factor family. (280 aa)
PLA2G4ACytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response (By similarity). (749 aa)
ABCA1ABCA1 isoform 1. (2234 aa)
PTCH1PTCH1 isoform 7. (1429 aa)
CRHCRH isoform 1. (199 aa)
NKX3-1NKX3-1 isoform 1. (236 aa)
ZDHHC8Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (715 aa)
NTSR1NTSR1 isoform 1; Belongs to the G-protein coupled receptor 1 family. (418 aa)
PLTPPLTP isoform 3. (440 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
SSTR4SSTR4 isoform 1; Belongs to the G-protein coupled receptor 1 family. (388 aa)
SCP2D1SCP2D1 isoform 1. (156 aa)
NR1H2NR1H2 isoform 11. (413 aa)
CR201_G0037528CYP4F3 isoform 2; Belongs to the cytochrome P450 family. (566 aa)
RETNRETN isoform 2. (108 aa)
ABCA7ABCA7 isoform 3. (2147 aa)
C1QTNF6C1QTNF6 isoform 1. (278 aa)
PLA2G6PLA2G6 isoform 1. (805 aa)
ECRG4ECRG4 augurin precursor. (148 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (273 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
ENSPPYP00000014133annotation not available (94 aa)
CAV1Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...] (178 aa)
ABCB4ABCB4 isoform 3. (1223 aa)
DBIDBI isoform 2. (104 aa)
PLA2R1Soluble secretory phospholipase A2 receptor; Receptor for secretory phospholipase A2 (sPLA2). Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marro [...] (1463 aa)
ABCA12ABCA12 isoform 1. (2510 aa)
ERFEERFE isoform 3. (135 aa)
PPARGPeroxisome proliferator-activated receptor gamma. (477 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
TMF1TMF1 isoform 1. (992 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
CYP8B1Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (501 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
ATP8A1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1164 aa)
LRATLRAT isoform 2. (233 aa)
ACSL1ACSL1 isoform 4. (748 aa)
PLA2G3PLA2G3 isoform 1. (505 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
SPP1SPP1 isoform 6. (136 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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