STRINGSTRING
PLS1 PLS1 CLRN1 CLRN1 CLRN2 CLRN2 GRXCR1 GRXCR1 ADGRV1 ADGRV1 DCDC2 DCDC2 GRXCR2 GRXCR2 RIPOR2 RIPOR2 CLIC5 CLIC5 RSPH9 RSPH9 DOCK4 DOCK4 IDO1 IDO1 TRPA1 TRPA1 TMC1 TMC1 WHRN WHRN TPRN TPRN MPP1 MPP1 ENSPPYP00000023721 ENSPPYP00000023721 EPS8L2 EPS8L2 USH2A USH2A RHOC RHOC CDC14A CDC14A KNCN KNCN ESPN ESPN MYO3A MYO3A CR201_G0030294 CR201_G0030294 CDH23 CDH23 PCDH15 PCDH15 MORN4 MORN4 PDZD7 PDZD7 USH1C USH1C FCHSD2 FCHSD2 CR201_G0023224 CR201_G0023224 CR201_G0026161 CR201_G0026161 EPS8 EPS8 ADCY6 ADCY6 PTPRQ PTPRQ VEZT VEZT CR201_G0045973 CR201_G0045973 CR201_G0042177 CR201_G0042177 HOMER2 HOMER2 BBS2 BBS2 MYO1C MYO1C MYO15A MYO15A IFT20 IFT20 SLC9A3R1 SLC9A3R1 LOXHD1 LOXHD1 ATP8B1 ATP8B1 ATP8B3 ATP8B3 CEACAM16 CEACAM16 KPTN KPTN MKKS MKKS TMC2 TMC2 TSPEAR TSPEAR PVALB PVALB TRIOBP TRIOBP ELMOD3 ELMOD3 MYO3B MYO3B PJVK PJVK ESPNL ESPNL TWF2 TWF2 SLC4A7 SLC4A7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLS1PLS1 isoform 1. (631 aa)
CLRN1CLRN1 isoform 2. (232 aa)
CLRN2CLRN2 isoform 1. (249 aa)
GRXCR1GRXCR1 isoform 1. (231 aa)
ADGRV1ADGRV1 isoform 3; Belongs to the G-protein coupled receptor 2 family. (6076 aa)
DCDC2Doublecortin domain containing 2. (476 aa)
GRXCR2Glutaredoxin and cysteine rich domain containing 2. (248 aa)
RIPOR2T0162759 isoform 1. (1097 aa)
CLIC5Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (205 aa)
RSPH9RSPH9 isoform 2. (276 aa)
DOCK4DOCK4 isoform 1; Belongs to the DOCK family. (1958 aa)
IDO1IDO1 isoform 1. (403 aa)
TRPA1TRPA1 isoform 1; Belongs to the transient receptor (TC 1.A.4) family. (1119 aa)
TMC1Transmembrane channel-like protein. (761 aa)
WHRNWHRN isoform 2. (907 aa)
TPRNTPRN isoform 2. (404 aa)
MPP155 kDa erythrocyte membrane protein; Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity). Belongs to the MAGUK family. (466 aa)
ENSPPYP00000023721annotation not available (169 aa)
EPS8L2Epidermal growth factor receptor kinase substrate 8-like protein 2; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity). In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). (1531 aa)
USH2AUSH2A isoform 2. (4749 aa)
RHOCRho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity). (192 aa)
CDC14ACell division cycle 14A. (594 aa)
KNCNKNCN isoform 1. (123 aa)
ESPNESPN isoform 1. (848 aa)
MYO3AMYO3A isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1575 aa)
CR201_G0030294CDH23 isoform 6. (250 aa)
CDH23CDH23 isoform 1. (2498 aa)
PCDH15PCDH15 isoform 18. (1163 aa)
MORN4MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma. (146 aa)
PDZD7PDZ domain-containing protein 7; In cochlear developing hair cells, essential in organizing the USH2 complex at stereocilia ankle links. Blocks inhibition of adenylate cyclase activity mediated by ADGRV1. (477 aa)
USH1CUSH1C isoform 9. (403 aa)
FCHSD2FCH and double SH3 domains 2. (764 aa)
CR201_G0023224MYO7A isoform 2. (1350 aa)
CR201_G0026161USH1C isoform 8. (559 aa)
EPS8Epidermal growth factor receptor kinase substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and acti [...] (824 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1165 aa)
PTPRQPTPRQ isoform 5. (154 aa)
VEZTVezatin; Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process. (779 aa)
CR201_G0045973STRC isoform 2. (1473 aa)
CR201_G0042177CIB2 isoform 1. (346 aa)
HOMER2HOMER2 isoform 1. (397 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (720 aa)
MYO1CMYO1C isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
MYO15AMYO15A isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (3281 aa)
IFT20IFT20 isoform 6. (158 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (357 aa)
LOXHD1LOXHD1 isoform 1. (1714 aa)
ATP8B1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1212 aa)
ATP8B3Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1227 aa)
CEACAM16CEACAM16 isoform 1. (482 aa)
KPTNKPTN isoform 1. (435 aa)
MKKSMcKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin; Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis. Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis. (570 aa)
TMC2Transmembrane channel-like protein. (905 aa)
TSPEARTSPEAR isoform 1. (670 aa)
PVALBPVALB isoform 1; Belongs to the parvalbumin family. (110 aa)
TRIOBPTRIOBP isoform 1. (2199 aa)
ELMOD3ELMOD3 isoform 14. (381 aa)
MYO3BMYO3B isoform 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1306 aa)
PJVKDFNB59 isoform 1. (352 aa)
ESPNLESPNL isoform 1. (1002 aa)
TWF2Twinfilin-2; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity); Belongs to the actin-binding proteins ADF family. Twinfilin subfamily. (349 aa)
SLC4A7Anion exchange protein. (1214 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.