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| | DDRGK1 | DDRGK domain containing 1. (314 aa) |
| | NOP53 | Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (445 aa) |
| | GSK3A | Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa) |
| | DDA1 | DET1- and DDB1-associated protein 1; May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins (By similarity); Belongs to the DDA1 family. (102 aa) |
| | GIPC1 | GIPC PDZ domain containing family member 1. (333 aa) |
| | RAD23A | RAD23A isoform 1. (350 aa) |
| | SIRT6 | SIRT6 isoform 1. (355 aa) |
| | ENSPPYP00000010521 | PDZ domain-containing protein GIPC. (584 aa) |
| | GIPC3 | GIPC3 isoform 1. (312 aa) |
| | FZR1 | FZR1 isoform 4. (420 aa) |
| | SGTA | Small glutamine rich tetratricopeptide repeat containing alpha. (313 aa) |
| | SMAD7 | Mothers against decapentaplegic homolog. (426 aa) |
| | USP14 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (435 aa) |
| | CLUL1 | Clusterin; Belongs to the clusterin family. (498 aa) |
| | CSNK1D | Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, dete [...] (404 aa) |
| | AXIN2 | AXIN2 isoform 1. (843 aa) |
| | TLK2 | TLK2 isoform 9. (640 aa) |
| | GABARAP | Gamma-aminobutyric acid receptor-associated protein-like 1; Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity); Belongs to the ATG8 family. (117 aa) |
| | CBFA2T3 | CBFA2T3 isoform 1. (630 aa) |
| | PABPN1L | PABPN1L isoform 3. (277 aa) |
| | HERPUD1 | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein; Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway. (391 aa) |
| | N4BP1 | N4BP1 isoform 1. (894 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (603 aa) |
| | USP7 | USP7 isoform 8; Belongs to the peptidase C19 family. (1082 aa) |
| | ELOB | ELOB isoform 1. (160 aa) |
| | STUB1 | STIP1 homology and U-box containing protein 1. (303 aa) |
| | CR201_G0054585 | AXIN1 isoform 6. (551 aa) |
| | LOC100445631 | GABARAPL1 isoform 2. (113 aa) |
| | DET1 | DET1 isoform 5. (472 aa) |
| | FBXO22 | F-box only protein 22; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome- dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function (By similarity). (405 aa) |
| | ARIH1 | RBR-type E3 ubiquitin transferase. (557 aa) |
| | PIAS1 | PIAS1 isoform 1. (683 aa) |
| | MAP1A | MAP1A isoform 2. (3039 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (413 aa) |
| | BAG5 | BCL2 associated athanogene 5. (447 aa) |
| | PSEN1 | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (463 aa) |
| | SOCS4 | Suppressor of cytokine signaling 4; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity). (373 aa) |
| | STYX | Serine/threonine/tyrosine-interacting protein; Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (By similarity). Seems to play a role in spermiogenesis (By similarity). Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (223 aa) |
| | HECTD1 | HECT domain E3 ubiquitin protein ligase 1. (2610 aa) |
| | ENSPPYP00000006214 | annotation not available (312 aa) |
| | FBXW8 | FBXW8 isoform 2. (596 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (317 aa) |
| | PRICKLE1 | Prickle planar cell polarity protein 1. (831 aa) |
| | GABARAPL1 | Gamma-aminobutyric acid receptor-associated protein-like 1. (85 aa) |
| | USP5 | Ubiquitin carboxyl-terminal hydrolase 5; Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys- 48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity (By similarity). (840 aa) |
| | ENSPPYP00000004644 | annotation not available (118 aa) |
| | TTC36 | Tetratricopeptide repeat domain 36. (189 aa) |
| | UBQLN3 | UBQLN3 isoform 1. (655 aa) |
| | SVIP | Small VCP/p97-interacting protein; Belongs to the SVIP family. (77 aa) |
| | UBXN1 | UBXN1 isoform 1. (296 aa) |
| | CR201_G0023845 | TLK2 isoform 10. (648 aa) |
| | WAC | WW domain containing adaptor with coiled-coil. (647 aa) |
| | CR201_G0044109 | RACK1 isoform 5. (346 aa) |
| | DVL1 | DVL1 isoform 2. (594 aa) |
| | PARK7 | PARK7 isoform 1. (189 aa) |
| | RPL11 | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (178 aa) |
| | RNF19B | RBR-type E3 ubiquitin transferase. (629 aa) |
| | CDC20 | Cell division cycle 20. (499 aa) |
| | CR201_G0041907 | Serine/threonine-protein kinase PLK. (286 aa) |
| | ZYG11B | Zyg-11 family member B, cell cycle regulator. (744 aa) |
| | ZYG11A | Zyg-11 family member A, cell cycle regulator. (759 aa) |
| | GIPC2 | GIPC2 isoform 2. (316 aa) |
| | GLMN | Glomulin, FKBP associated protein. (594 aa) |
| | UBQLN4 | UBQLN4 isoform 1. (600 aa) |
| | COP1 | COP1 E3 ubiquitin ligase. (731 aa) |
| | UCHL5 | Ubiquitin carboxyl-terminal hydrolase. (396 aa) |
| | SIRT2 | NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtu [...] (389 aa) |
| | DESI1 | DESI1 isoform 1. (242 aa) |
| | LRRK2 | LRRK2 isoform 3. (1560 aa) |
| | ANKIB1 | RBR-type E3 ubiquitin transferase. (1089 aa) |
| | CR201_G0044109-2 | RACK1 isoform 22. (230 aa) |
| | PSMD10 | Proteasome 26S subunit, non-ATPase 10. (226 aa) |
| | OGT | OGT isoform 1. (1045 aa) |
| | TAF1 | Transcription initiation factor TFIID subunit. (1755 aa) |
| | UBQLN2 | UBQLN2 isoform 1. (624 aa) |
| | ARAF | A-Raf proto-oncogene, serine/threonine kinase. (606 aa) |
| | USP9X | Ubiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2554 aa) |
| | RACK1 | RACK1 isoform 13. (372 aa) |
| | ZER1 | Protein zer-1 homolog; Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N- myristoylation; Belongs to the [...] (730 aa) |
| | RAD23B | RAD23 homolog B, nucleotide excision repair protein. (337 aa) |
| | UBQLN1 | Ubiquilin-1; Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin- proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a lin [...] (577 aa) |
| | IL33 | Interleukin-33; Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (By similarity); Belongs to the IL-1 family. Highly divergent. (270 aa) |
| | VCP | Transitional endoplasmic reticulum ATPase isoform X1. (806 aa) |
| | TRIB1 | Tribbles pseudokinase 1. (372 aa) |
| | EIF3H | Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (352 aa) |
| | SDCBP | SDCBP isoform 3. (297 aa) |
| | PBK | PDZ binding kinase. (322 aa) |
| | CLU | Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (415 aa) |
| | CCAR2 | Cell cycle and apoptosis regulator protein 2; Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53- mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part [...] (917 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (460 aa) |
| | NUB1 | NUB1 isoform 2. (662 aa) |
| | CAV1 | Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...] (178 aa) |
| | GNA12 | GNA12 isoform 1. (381 aa) |
| | ZFAND2A | AN1-type zinc finger protein 2A. (193 aa) |
| | CR201_G0036895 | PRKN isoform 8. (335 aa) |
| | CR201_G0047659 | RBR-type E3 ubiquitin transferase. (219 aa) |
| | UFL1 | UFL1 isoform 2. (773 aa) |
| | GCLC | Glutamate-cysteine ligase catalytic subunit. (637 aa) |
| | HSP90AB1 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] (724 aa) |
| | BAG6 | BCL2 associated athanogene 6. (1126 aa) |
| | TRIM39 | Tripartite motif-containing protein 39. (488 aa) |
| | RNF144B | RBR-type E3 ubiquitin transferase. (303 aa) |
| | FOXF2 | FOXF2 isoform 1. (184 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | SH3RF2 | SH3 domain containing ring finger 2. (729 aa) |
| | RNF14 | RBR-type E3 ubiquitin transferase. (474 aa) |
| | CAMLG | Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (299 aa) |
| | RNF180 | E3 ubiquitin-protein ligase RNF180; E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2. (579 aa) |
| | CDC20B | CDC20B isoform 4. (518 aa) |
| | DAB2 | DAB adaptor protein 2. (770 aa) |
| | NKD2 | NKD2 isoform 1. (455 aa) |
| | BBS7 | Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa) |
| | ENSPPYP00000016659 | annotation not available (592 aa) |
| | RCHY1 | Ring finger and CHY zinc finger domain containing 1. (261 aa) |
| | UBE2K | Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa) |
| | SMARCC1 | SMARCC1 isoform 1. (1111 aa) |
| | ARIH2 | RBR-type E3 ubiquitin transferase. (456 aa) |
| | FHIT | Bis(5'-adenosyl)-triphosphatase. (147 aa) |
| | RYBP | RYBP isoform 1. (291 aa) |
| | ENSPPYP00000015333 | annotation not available (74 aa) |
| | GSK3B | GSK3B isoform 2; Belongs to the protein kinase superfamily. (380 aa) |
| | MKRN2 | Makorin ring finger protein 2. (416 aa) |
| | DNAJB2 | DNAJB2 isoform 1. (298 aa) |
| | NFE2L2 | NFE2L2 isoform 2. (606 aa) |
| | RNF144A | RBR-type E3 ubiquitin transferase. (292 aa) |
| | TRIB2 | Tribbles homolog 2; Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily. (343 aa) |
| | SOCS5 | Suppressor of cytokine signaling 5. (536 aa) |
| | XPO1 | XPO1 isoform 9. (1034 aa) |
| | CR201_G0003257 | COMMD1 isoform 4. (146 aa) |
| | CR201_G0043010 | SH3RF3 isoform 1. (650 aa) |
| | RBX1 | RBX1 isoform 1. (108 aa) |
| | LOC100447547 | T0085674 isoform 1; Belongs to the protein kinase superfamily. (416 aa) |
| | XBP1 | X-box binding protein 1. (262 aa) |
| | AURKA | AURKA isoform 10; Belongs to the protein kinase superfamily. (404 aa) |
| | TRIB3 | TRIB3 isoform 1. (358 aa) |
| | HSPBP1 | HSPBP1 isoform 1. (240 aa) |
