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| | CR201_G0055216 | C16orf45 isoform 2. (115 aa) |
| | KIF2B | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (674 aa) |
| | NSF | Vesicle-fusing ATPase; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity); Belongs to the AAA ATPase family. (816 aa) |
| | ENSPPYP00000009346 | annotation not available (387 aa) |
| | KIF18B | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (409 aa) |
| | DHX8 | DEAH-box helicase 8. (1220 aa) |
| | BECN1 | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] (452 aa) |
| | SMARCE1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (411 aa) |
| | KIF19 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (829 aa) |
| | MRPL58 | Mitochondrial ribosomal protein L58. (206 aa) |
| | CHMP6 | Charged multivesicular body protein 6; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] (178 aa) |
| | VMP1 | Vacuole membrane protein 1; Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions. Plays a role in the initial stages of the autophagic process through its interaction with BECN1. Required for autophagosome formation (By similarity). Belongs to the VMP1 family. (406 aa) |
| | PPP1R9B | PPP1R9B isoform 1. (729 aa) |
| | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa) |
| | EPG5 | EPG5 isoform 1. (2578 aa) |
| | SH3GL1 | SH3GL1 isoform 4. (305 aa) |
| | SMARCA4 | SMARCA4 isoform 2. (1647 aa) |
| | ENSPPYP00000011173 | annotation not available (222 aa) |
| | NAPA | NAPA isoform 1. (276 aa) |
| | GRWD1 | GRWD1 isoform 1. (446 aa) |
| | CHMP2A | CHMP2A isoform 1. (222 aa) |
| | MAP1LC3C | MAP1LC3C isoform 1. (147 aa) |
| | DNAJC6 | DNAJC6 isoform 6. (766 aa) |
| | DSTN | Destrin, actin depolymerizing factor; Belongs to the actin-binding proteins ADF family. (165 aa) |
| | NAPB | NAPB isoform 4. (298 aa) |
| | VPS16 | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (839 aa) |
| | CHMP4B | CHMP4B isoform 1. (210 aa) |
| | MAP1LC3A | Microtubule associated protein 1 light chain 3 alpha. (121 aa) |
| | SYNJ1 | SYNJ1 isoform 6. (1396 aa) |
| | CR201_G0050646 | MICAL3 isoform 4. (958 aa) |
| | MICAL3 | MICAL3 isoform 13. (948 aa) |
| | SMARCB1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (395 aa) |
| | TFIP11 | Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] (828 aa) |
| | SNAP29 | Synaptosomal-associated protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions. (258 aa) |
| | CHMP3 | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] (222 aa) |
| | VAMP8 | Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex. Also required for dense-granule secretion in platelets. Plays als [...] (253 aa) |
| | CALM1-2 | Calmodulin 2. (149 aa) |
| | ENSPPYP00000014053 | annotation not available (357 aa) |
| | NCKAP5 | NCKAP5 isoform 3. (1841 aa) |
| | NOSTRIN | NOSTRIN isoform 3. (506 aa) |
| | TNP1 | Transition protein 1. (55 aa) |
| | VIL1 | VIL1 isoform 1. (839 aa) |
| | GSK3B | GSK3B isoform 2; Belongs to the protein kinase superfamily. (380 aa) |
| | CHMP2B | Charged multivesicular body protein 2b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] (213 aa) |
| | APEH | APEH isoform 1. (727 aa) |
| | SMARCC1 | SMARCC1 isoform 1. (1111 aa) |
| | PIK3R4 | Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). (1357 aa) |
| | GAK | GAK isoform 7. (1062 aa) |
| | WDR1 | WDR1 isoform 1. (606 aa) |
| | MFSD8 | MFSD8 isoform 10. (518 aa) |
| | ABCE1 | ABCE1 isoform 1. (599 aa) |
| | SMN1 | Survival motor neuron protein; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the ch [...] (276 aa) |
| | LIX1 | Limb and CNS expressed 1. (282 aa) |
| | ETF1 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. (437 aa) |
| | SNX14 | Sorting nexin-14; Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family. (943 aa) |
| | MICAL1 | MICAL1 isoform 2. (1015 aa) |
| | MTRF1L | Mitochondrial translational release factor 1 like. (380 aa) |
| | CR201_G0022130 | DYRK3 isoform 5. (68 aa) |
| | SNAPIN | SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa) |
| | LIX1L | Limb and CNS expressed 1 like. (337 aa) |
| | KIF2C | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (706 aa) |
| | ARID1A | ARID1A isoform 1. (2006 aa) |
| | STMN1 | Stathmin; Belongs to the stathmin family. (149 aa) |
| | PEX14 | PEX14 isoform 2. (373 aa) |
| | KIF5B | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (964 aa) |
| | DDIT4 | DNA damage inducible transcript 4. (232 aa) |
| | PPP1CA | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa) |
| | CFL1 | CFL1 isoform 4; Belongs to the actin-binding proteins ADF family. (165 aa) |
| | CKAP5 | CKAP5 isoform 3. (2022 aa) |
| | KIF18A | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (880 aa) |
| | TSG101 | TSG101 isoform 4. (352 aa) |
| | MICAL2 | Microtubule associated monooxygenase, calponin and LIM domain containing 2. (1124 aa) |
| | UVRAG | UV radiation resistance associated. (699 aa) |
| | HSPA8 | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] (646 aa) |
| | ARID2 | AT-rich interaction domain 2. (1836 aa) |
| | NCKAP5L | NCKAP5L isoform 2. (925 aa) |
| | ENSPPYP00000005135 | annotation not available (142 aa) |
| | SMARCD1 | SMARCD1 isoform 1. (644 aa) |
| | NFE2 | NFE2 isoform 1. (373 aa) |
| | PYM1 | PYM homolog 1, exon junction complex associated factor. (204 aa) |
| | SMARCC2 | SMARCC2 isoform 7. (1218 aa) |
| | ATP2A2 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (950 aa) |
| | ENSPPYP00000005659 | annotation not available (212 aa) |
| | VPS33A | T0002578 isoform 1; Belongs to the STXBP/unc-18/SEC1 family. (596 aa) |
| | C12orf65 | Chromosome 12 open reading frame 65. (166 aa) |
| | MTRF1 | Mitochondrial translation release factor 1. (445 aa) |
| | CR201_G0016717 | RUBCNL isoform 6. (570 aa) |
| | SUPT16H | SPT16 homolog, facilitates chromatin remodeling subunit. (1047 aa) |
| | CHMP4A | CHMP4A isoform 4. (258 aa) |
| | CFL2 | CFL2 isoform 1; Belongs to the actin-binding proteins ADF family. (166 aa) |
| | TECPR1 | Tectonin beta-propeller repeat-containing protein 1; Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation (By similarity); Belongs to the TECPR1 family. (1165 aa) |
| | SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa) |
| | CHMP7 | Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway. (453 aa) |
| | NRG1 | NRG1 isoform 10. (692 aa) |
| | STMN2 | Stathmin; Belongs to the stathmin family. (179 aa) |
| | ZFAND1 | ZFAND1 isoform 8. (268 aa) |
| | CHMP4C | Charged multivesicular body protein 4C. (233 aa) |
| | MYC | MYC isoform 1. (453 aa) |
| | VCP | Transitional endoplasmic reticulum ATPase isoform X1. (806 aa) |
| | KIF24 | KIF24 isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1234 aa) |
| | CHMP5 | Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] (219 aa) |
| | UBQLN1 | Ubiquilin-1; Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin- proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a lin [...] (577 aa) |
| | STX17 | STX17 isoform 1; Belongs to the syntaxin family. (302 aa) |
| | GSN | GSN isoform 1. (732 aa) |
| | HDAC6 | HDAC6 isoform 2. (1208 aa) |
| | ENSPPYP00000022952 | annotation not available (197 aa) |
| | LAMP2 | Lysosomal associated membrane protein 2. (410 aa) |
| | HMGA1 | HMGA1 isoform 1. (104 aa) |
| | SSRP1 | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (712 aa) |
| | ENSPPYP00000024141 | annotation not available (55 aa) |
| | ATG14 | Autophagy related 14. (492 aa) |
| | CALM1 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa) |
| | DNAJC17 | DNAJC17 isoform 3. (304 aa) |
| | CR201_G0043368 | SH3GL3 isoform 2. (284 aa) |
| | ENSPPYP00000008060 | annotation not available (65 aa) |
| | CLN3 | Battenin. (438 aa) |
| | KATNB1 | Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Micr [...] (607 aa) |
| | VPS4A | VPS4A isoform 1; Belongs to the AAA ATPase family. (437 aa) |
| | MAP1LC3B | MAP1LC3B isoform 1. (129 aa) |
| | CHMP1A | Charged multivesicular body protein 1a; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] (196 aa) |
| | BMERB1 | bMERB domain-containing protein 1. (158 aa) |
