(13 nodes) Adherens junction assembly network (Pongo abelii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DLG5	DLG5 isoform 1; Belongs to the MAGUK family. (1809 aa)
	VCL	VCL isoform 2. (1134 aa)
	JAM3	JAM3 isoform 1. (315 aa)
	RAMP2	Receptor activity modifying protein 2. (175 aa)
	TBCD	TBCD isoform 3. (1192 aa)
	HIPK1	HIPK1 isoform 4. (1209 aa)
	SMAD7	Mothers against decapentaplegic homolog. (426 aa)
	CR201_G0044279	PIP5K1C isoform 1. (576 aa)
	CTNNB1	CTNNB1 isoform 2. (781 aa)
	PAK2	Non-specific serine/threonine protein kinase. (502 aa)
	FER	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (821 aa)
	ACTB	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
	ZNF703	ZNF703 isoform 1. (591 aa)

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	CTNNB1	ENSPPYP00000019427	ENSPPYP00000015644	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	CTNNB1 isoform 2.	0.679
ACTB	VCL	ENSPPYP00000019427	ENSPPYP00000002699	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	VCL isoform 2.	0.763
CTNNB1	ACTB	ENSPPYP00000015644	ENSPPYP00000019427	CTNNB1 isoform 2.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.679
CTNNB1	DLG5	ENSPPYP00000015644	ENSPPYP00000002681	CTNNB1 isoform 2.	DLG5 isoform 1; Belongs to the MAGUK family.	0.502
CTNNB1	FER	ENSPPYP00000015644	ENSPPYP00000017524	CTNNB1 isoform 2.	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.	0.928
CTNNB1	PAK2	ENSPPYP00000015644	ENSPPYP00000016156	CTNNB1 isoform 2.	Non-specific serine/threonine protein kinase.	0.550
CTNNB1	SMAD7	ENSPPYP00000015644	ENSPPYP00000010278	CTNNB1 isoform 2.	Mothers against decapentaplegic homolog.	0.776
CTNNB1	VCL	ENSPPYP00000015644	ENSPPYP00000002699	CTNNB1 isoform 2.	VCL isoform 2.	0.921
DLG5	CTNNB1	ENSPPYP00000002681	ENSPPYP00000015644	DLG5 isoform 1; Belongs to the MAGUK family.	CTNNB1 isoform 2.	0.502
DLG5	PAK2	ENSPPYP00000002681	ENSPPYP00000016156	DLG5 isoform 1; Belongs to the MAGUK family.	Non-specific serine/threonine protein kinase.	0.420
FER	CTNNB1	ENSPPYP00000017524	ENSPPYP00000015644	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.	CTNNB1 isoform 2.	0.928
FER	PAK2	ENSPPYP00000017524	ENSPPYP00000016156	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.	Non-specific serine/threonine protein kinase.	0.444
PAK2	CTNNB1	ENSPPYP00000016156	ENSPPYP00000015644	Non-specific serine/threonine protein kinase.	CTNNB1 isoform 2.	0.550
PAK2	DLG5	ENSPPYP00000016156	ENSPPYP00000002681	Non-specific serine/threonine protein kinase.	DLG5 isoform 1; Belongs to the MAGUK family.	0.420
PAK2	FER	ENSPPYP00000016156	ENSPPYP00000017524	Non-specific serine/threonine protein kinase.	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.	0.444
SMAD7	CTNNB1	ENSPPYP00000010278	ENSPPYP00000015644	Mothers against decapentaplegic homolog.	CTNNB1 isoform 2.	0.776
VCL	ACTB	ENSPPYP00000002699	ENSPPYP00000019427	VCL isoform 2.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.763
VCL	CTNNB1	ENSPPYP00000002699	ENSPPYP00000015644	VCL isoform 2.	CTNNB1 isoform 2.	0.921