(7 nodes) High-density lipoprotein particle assembly network (Pongo abelii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ABCA1	ABCA1 isoform 1. (2234 aa)
	PRKACB	PRKACB isoform 9; Belongs to the protein kinase superfamily. (354 aa)
	APOA1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity). (219 aa)
	ABCA7	ABCA7 isoform 3. (2147 aa)
	APOE	Apolipoprotein E. (317 aa)
	PRKACG	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
	APOA4	Apolipoprotein A4. (416 aa)

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	APOA1	ENSPPYP00000021810	ENSPPYP00000004472	ABCA1 isoform 1.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	0.999
ABCA1	APOE	ENSPPYP00000021810	ENSPPYP00000011298	ABCA1 isoform 1.	Apolipoprotein E.	0.850
ABCA1	PRKACB	ENSPPYP00000021810	ENSPPYP00000001400	ABCA1 isoform 1.	PRKACB isoform 9; Belongs to the protein kinase superfamily.	0.482
ABCA1	PRKACG	ENSPPYP00000021810	ENSPPYP00000021585	ABCA1 isoform 1.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.478
ABCA7	APOA1	ENSPPYP00000010440	ENSPPYP00000004472	ABCA7 isoform 3.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	0.969
ABCA7	APOE	ENSPPYP00000010440	ENSPPYP00000011298	ABCA7 isoform 3.	Apolipoprotein E.	0.580
APOA1	ABCA1	ENSPPYP00000004472	ENSPPYP00000021810	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	ABCA1 isoform 1.	0.999
APOA1	ABCA7	ENSPPYP00000004472	ENSPPYP00000010440	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	ABCA7 isoform 3.	0.969
APOA1	APOA4	ENSPPYP00000004472	ENSPPYP00000024275	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Apolipoprotein A4.	0.982
APOA1	APOE	ENSPPYP00000004472	ENSPPYP00000011298	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Apolipoprotein E.	0.997
APOA4	APOA1	ENSPPYP00000024275	ENSPPYP00000004472	Apolipoprotein A4.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	0.982
APOA4	APOE	ENSPPYP00000024275	ENSPPYP00000011298	Apolipoprotein A4.	Apolipoprotein E.	0.989
APOE	ABCA1	ENSPPYP00000011298	ENSPPYP00000021810	Apolipoprotein E.	ABCA1 isoform 1.	0.850
APOE	ABCA7	ENSPPYP00000011298	ENSPPYP00000010440	Apolipoprotein E.	ABCA7 isoform 3.	0.580
APOE	APOA1	ENSPPYP00000011298	ENSPPYP00000004472	Apolipoprotein E.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	0.997
APOE	APOA4	ENSPPYP00000011298	ENSPPYP00000024275	Apolipoprotein E.	Apolipoprotein A4.	0.989
APOE	PRKACB	ENSPPYP00000011298	ENSPPYP00000001400	Apolipoprotein E.	PRKACB isoform 9; Belongs to the protein kinase superfamily.	0.457
APOE	PRKACG	ENSPPYP00000011298	ENSPPYP00000021585	Apolipoprotein E.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.457
PRKACB	ABCA1	ENSPPYP00000001400	ENSPPYP00000021810	PRKACB isoform 9; Belongs to the protein kinase superfamily.	ABCA1 isoform 1.	0.482
PRKACB	APOE	ENSPPYP00000001400	ENSPPYP00000011298	PRKACB isoform 9; Belongs to the protein kinase superfamily.	Apolipoprotein E.	0.457