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| | EXOSC5 | EXOSC5 isoform 1. (187 aa) |
| | SAMD4B | SAMD4B isoform 1. (735 aa) |
| | NUDT19 | NUDT19 isoform 1. (317 aa) |
| | UPF1 | UPF1 isoform 2. (1076 aa) |
| | LSM4 | U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (139 aa) |
| | PDE4C | Phosphodiesterase. (713 aa) |
| | DNASE2 | Deoxyribonuclease 2, lysosomal. (360 aa) |
| | RNASEH2A | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (300 aa) |
| | TRIR | Telomerase RNA component interacting RNase. (176 aa) |
| | PDE4A | Phosphodiesterase. (789 aa) |
| | KHSRP | KHSRP isoform 3. (637 aa) |
| | LSM7 | LSM7 isoform 1. (145 aa) |
| | CTIF | CTIF isoform 1. (505 aa) |
| | EIF4A3 | Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. (411 aa) |
| | NT5C | 5', 3'-nucleotidase, cytosolic. (201 aa) |
| | DDX5 | Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] (614 aa) |
| | ERN1 | ERN1 isoform 1. (963 aa) |
| | CASC3 | CASC3 isoform 1. (701 aa) |
| | NT5C3B | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (300 aa) |
| | CNP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family. (420 aa) |
| | SMG8 | Protein SMG8. (987 aa) |
| | SLFN12L | Schlafen family member 12-like. (619 aa) |
| | SLFN13 | SLFN13 isoform 6. (579 aa) |
| | SLFN12 | SLFN12 isoform 1. (578 aa) |
| | SARM1 | Sterile alpha and TIR motif containing 1. (724 aa) |
| | ENSPPYP00000009075 | annotation not available (261 aa) |
| | NT5M | NT5M isoform 2. (228 aa) |
| | METTL16 | U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...] (562 aa) |
| | SMG6 | Telomerase-binding protein EST1A; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER). (1421 aa) |
| | CR201_G0047047 | SMG1 isoform 2. (163 aa) |
| | PABPN1L | PABPN1L isoform 3. (277 aa) |
| | MLYCD | T0129743 isoform 1. (381 aa) |
| | NUDT7 | Nudix hydrolase 7. (238 aa) |
| | EXOSC6 | Exosome complex component MTR3. (271 aa) |
| | EDC4 | Enhancer of mRNA decapping 4. (1401 aa) |
| | CNOT1 | CCR4-NOT transcription complex subunit 1. (2376 aa) |
| | PAPD5 | PAPD5 isoform 1. (508 aa) |
| | DCTPP1 | dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. (170 aa) |
| | ERN2 | ERN2 isoform 2. (974 aa) |
| | SMG1 | SMG1 isoform 8; Belongs to the PI3/PI4-kinase family. (2434 aa) |
| | PARN | Poly(A)-specific ribonuclease PARN; 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsens [...] (640 aa) |
| | GSPT1 | GSPT1 isoform 2. (689 aa) |
| | ENSPPYP00000007918 | annotation not available (151 aa) |
| | NTHL1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (312 aa) |
| | PDE8A | Phosphodiesterase. (783 aa) |
| | ISG20 | Interferon stimulated exonuclease gene 20. (181 aa) |
| | NEIL1 | Nei like DNA glycosylase 1. (390 aa) |
| | EDC3 | Enhancer of mRNA-decapping protein 3; Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping (By similarity); Belongs to the EDC3 family. (505 aa) |
| | DIS3L | DIS3-like exonuclease 1; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. (1053 aa) |
| | DUT | Deoxyuridine triphosphatase. (252 aa) |
| | ADAL | ADAL isoform 4. (334 aa) |
| | DICER1 | Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1922 aa) |
| | HPRT1 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa) |
| | CR201_G0006690 | UPF3B isoform 4. (331 aa) |
| | ENSPPYP00000022846 | annotation not available (149 aa) |
| | NBDY | Negative regulator of P-body association; Promotes dispersal of P-body components and is likely to play a role in the mRNA decapping process. (68 aa) |
| | GSPT2 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3B; Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). (628 aa) |
| | LOC100443257 | Diphosphoinositol polyphosphate phosphohydrolase 3-beta. (164 aa) |
| | LOC100443622 | NUDT10 isoform 1. (164 aa) |
| | ADA2 | Adenosine deaminase 2; Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity (By similarity). (511 aa) |
| | ENTPD8 | Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (495 aa) |
| | ENTPD2 | ENTPD2 isoform 2; Belongs to the GDA1/CD39 NTPase family. (408 aa) |
| | REXO4 | REXO4 isoform 2. (421 aa) |
| | EXOSC2 | EXOSC2 isoform 3. (293 aa) |
| | ENDOG | Endonuclease. (297 aa) |
| | ENSPPYP00000022024 | annotation not available (493 aa) |
| | RC3H2 | RC3H2 isoform 1. (1143 aa) |
| | NUDT15 | Nudix hydrolase domain-containing protein. (164 aa) |
| | CDADC1 | Cytidine and dCMP deaminase domain-containing protein 1; May play an important role in testicular development and spermatogenesis; Belongs to the cytidine and deoxycytidylate deaminase family. (515 aa) |
| | RNASEH2B | RNASEH2B isoform 3. (311 aa) |
| | DIS3 | DIS3 isoform 1; Belongs to the RNR ribonuclease family. (957 aa) |
| | UPF3A | UPF3A regulator of nonsense mediated mRNA decay. (476 aa) |
| | APEX1 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa) |
| | PNP | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa) |
| | METTL3 | Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa) |
| | SAMD4A | SAMD4A isoform 1. (617 aa) |
| | ZFP36L1 | ZFP36 ring finger protein like 1. (338 aa) |
| | LOC100452391 | Protein mago nashi homolog isoform X3. (149 aa) |
| | DERA | Deoxyribose-phosphate aldolase. (318 aa) |
| | SMUG1 | SMUG1 isoform 14. (177 aa) |
| | PYM1 | PYM homolog 1, exon junction complex associated factor. (204 aa) |
| | PAN2 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1059 aa) |
| | CNOT2 | CNOT2 isoform 22. (466 aa) |
| | NUDT4 | Diphosphoinositol polyphosphate phosphohydrolase 2; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5- phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity); Belongs to the Nudix hyd [...] (180 aa) |
| | TDG | Thymine DNA glycosylase. (410 aa) |
| | UNG | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (313 aa) |
| | OAS2 | OAS2 isoform 1. (563 aa) |
| | PAN3 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (741 aa) |
| | EXOSC8 | Exosome component 8. (276 aa) |
| | SUCLA2 | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (463 aa) |
| | YTHDF2 | YTHDF2 isoform 2. (494 aa) |
| | PPP1R8 | Protein phosphatase 1 regulatory subunit 8. (351 aa) |
| | LIN28A | LIN28A isoform 1. (209 aa) |
| | PNRC2 | Proline rich nuclear receptor coactivator 2. (139 aa) |
| | CDA | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa) |
| | MRTO4 | Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (239 aa) |
| | EXOSC10 | EXOSC10 isoform 2. (905 aa) |
| | DFFA | DNA fragmentation factor subunit alpha. (331 aa) |
| | ACOT7 | Acyl-CoA thioesterase 7. (380 aa) |
| | CR201_G0025626 | DFFB isoform 3. (281 aa) |
| | FBH1 | FBXO18 isoform 2. (1006 aa) |
| | UPF2 | UPF2 isoform 1. (836 aa) |
| | NUDT5 | ADP-sugar pyrophosphatase; Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place w [...] (219 aa) |
| | MTPAP | MTPAP isoform 2. (504 aa) |
| | NUDT13 | NUDT13 isoform 2. (329 aa) |
| | SUPV3L1 | SUPV3L1 isoform 1. (786 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1061 aa) |
| | ENTPD1 | ENTPD1 isoform 5; Belongs to the GDA1/CD39 NTPase family. (510 aa) |
| | EXOSC1 | Exosome component 1. (195 aa) |
| | ENTPD7 | Ectonucleoside triphosphate diphosphohydrolase 7; Preferentially hydrolyzes nucleoside 5'-triphosphates. The order of activity with respect to possible substrates is UTP > GTP > CTP (By similarity). (575 aa) |
| | LRRC27 | LRRC27 isoform 3. (486 aa) |
| | MUS81 | MUS81 isoform 3. (545 aa) |
| | RNASEH2C | Ribonuclease H2 subunit C. (164 aa) |
| | POLR2G | POLR2G isoform 1. (174 aa) |
| | SWT1 | SWT1 RNA endoribonuclease homolog. (900 aa) |
| | SMG7 | SMG7 nonsense mediated mRNA decay factor. (1137 aa) |
| | RC3H1 | RC3H1 isoform 1. (1094 aa) |
| | SMG5 | SMG5 nonsense mediated mRNA decay factor. (1016 aa) |
| | RBM8A | RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (174 aa) |
| | ENSPPYP00000021481 | annotation not available (599 aa) |
| | VCP | Transitional endoplasmic reticulum ATPase isoform X1. (806 aa) |
| | EXOSC3 | Exosome component 3. (275 aa) |
| | EXOSC4 | EXOSC4 isoform 1. (239 aa) |
| | EIF3E | Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (445 aa) |
| | DPYS | Dihydropyrimidinase. (519 aa) |
| | PABPC1 | Polyadenylate-binding protein 1; Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region deter [...] (636 aa) |
| | POP1 | POP1 isoform 2. (1024 aa) |
| | RIDA | Reactive intermediate imine deaminase A homolog. (137 aa) |
| | PDE7A | Phosphodiesterase. (493 aa) |
| | LSM1 | U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa) |
| | ENTPD4 | ENTPD4 isoform 4; Belongs to the GDA1/CD39 NTPase family. (541 aa) |
| | NUDT18 | Nudix hydrolase 18; Belongs to the Nudix hydrolase family. (323 aa) |
| | CNOT7 | CCR4-NOT transcription complex subunit 7. (285 aa) |
| | CNOT4 | CCR4-NOT transcription complex subunit 4. (710 aa) |
| | ENSPPYP00000019907 | annotation not available (59 aa) |
| | LSM5 | U6 snRNA-associated Sm-like protein LSm5; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (91 aa) |
| | NT5C3A | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (297 aa) |
| | UPP1 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (310 aa) |
| | NUDT1 | Nudix hydrolase 1; Belongs to the Nudix hydrolase family. (156 aa) |
| | RNASET2 | Ribonuclease T2. (256 aa) |
| | PDE10A | Phosphodiesterase. (780 aa) |
| | PNLDC1 | Poly(A)-specific ribonuclease PNLDC1; 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (By similarity). May act as a regulator of multipotency in embryonic stem cells (By similarity); Belongs to the CAF1 family. (530 aa) |
| | ZC3H12D | ZC3H12D isoform 1. (517 aa) |
| | BCLAF1 | BCL2 associated transcription factor 1. (921 aa) |
| | PDE7B | Phosphodiesterase. (450 aa) |
| | ENPP1 | ENPP1 isoform 1. (925 aa) |
| | ENPP3 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...] (796 aa) |
| | SMPDL3A | Acid sphingomyelinase-like phosphodiesterase. (404 aa) |
| | LIN28B | LIN28B isoform 2. (246 aa) |
| | NT5E | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa) |
| | ENPP4 | Bis(5'-adenosyl)-triphosphatase ENPP4; Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors (By similarity); Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. (453 aa) |
| | DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. (151 aa) |
| | APOBEC2 | APOBEC2 isoform 1. (224 aa) |
| | NUDT3 | Diphosphoinositol polyphosphate phosphohydrolase 1. (172 aa) |
| | DXO | Decapping exoribonuclease. (396 aa) |
| | SKIV2L | SKIV2L isoform 1. (1246 aa) |
| | LSM2 | U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (176 aa) |
| | DCP2 | m7GpppN-mRNA hydrolase; Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication- dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. The presence of a N(6)-methyladenosine methylation at the second transcr [...] (152 aa) |
| | MGAT1 | MGAT1 isoform 12. (445 aa) |
| | CNOT8 | CNOT8 isoform 14. (290 aa) |
| | ETF1 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. (437 aa) |
| | HINT1 | Histidine triad nucleotide-binding protein 1; Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guano [...] (126 aa) |
| | ENSPPYP00000017543 | annotation not available (232 aa) |
| | NUDT12 | Peroxisomal NADH pyrophosphatase NUDT12; Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. (506 aa) |
| | TTC37 | TTC37 isoform 1. (1505 aa) |
| | TENT2 | PAPD4 isoform 1. (460 aa) |
| | CR201_G0015966 | Phosphodiesterase. (1119 aa) |
| | PDE4D | Phosphodiesterase. (679 aa) |
| | MTREX | SKIV2L2 isoform 1. (1049 aa) |
| | PELO | Protein pelota homolog; Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). Belongs to the eukaryotic release factor 1 family. Pelota subfamily. (402 aa) |
| | LSM6 | LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated. (80 aa) |
| | NOCT | NOCT isoform 2. (431 aa) |
| | EXOSC9 | Exosome component 9. (439 aa) |
| | PDE5A | Phosphodiesterase. (833 aa) |
| | METTL14 | N6-adenosine-methyltransferase non-catalytic subunit; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (By simila [...] (380 aa) |
| | NUDT9 | NUDT9 isoform 1. (350 aa) |
| | HNRNPD | Heterogeneous nuclear ribonucleoprotein D. (355 aa) |
| | CNOT6L | CNOT6L isoform 1. (550 aa) |
| | ENSPPYP00000016187 | annotation not available (313 aa) |
| | NCBP2 | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (187 aa) |
| | XRN1 | 5'-3' exoribonuclease 1. (1706 aa) |
| | FOXL2 | FOXL2 isoform 1. (376 aa) |
| | LOC100434247 | NUDT16 isoform 1. (195 aa) |
| | CNOT10 | CNOT10 isoform 1. (744 aa) |
| | MLH1 | MLH1 isoform 1. (725 aa) |
| | EXOG | EXOG isoform 2. (368 aa) |
| | ENTPD3 | ENTPD3 isoform 1; Belongs to the GDA1/CD39 NTPase family. (529 aa) |
| | EXOSC7 | EXOSC7 isoform 6. (441 aa) |
| | TREX1 | Three prime repair exonuclease 1. (369 aa) |
| | WDR82 | WDR82 isoform 1. (308 aa) |
| | DCP1A | DCP1A isoform 1. (582 aa) |
| | PDE12 | PDE12 isoform 2. (608 aa) |
| | DNASE1L3 | Deoxyribonuclease; Belongs to the DNase I family. (305 aa) |
| | FHIT | Bis(5'-adenosyl)-triphosphatase. (147 aa) |
| | SUCLG2 | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (399 aa) |
| | SETMAR | SET domain and mariner transposase fusion gene. (684 aa) |
| | OGG1 | OGG1 isoform 9. (345 aa) |
| | ENSPPYP00000015058 | annotation not available (73 aa) |
| | MBD4 | Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (573 aa) |
| | DIS3L2 | DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (797 aa) |
| | CNOT9 | CCR4-NOT transcription complex subunit 9; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down- regulation of MYB- and JUN-dependent transcription. Enhances ligand- dependent transcriptional activity of nuclear hormone receptors. May play a role in cell d [...] (299 aa) |
| | SSB | Small RNA binding exonuclease protection factor La. (405 aa) |
| | CR201_G0040093 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (278 aa) |
| | ENSPPYP00000014325 | LOW QUALITY PROTEIN: polyadenylate-binding protein 1. (270 aa) |
| | POLR2D | RNA polymerase II subunit D. (142 aa) |
| | NBAS | NBAS isoform 1. (2330 aa) |
| | XDH | XDH isoform 1. (1153 aa) |
| | ZFP36L2 | ZFP36L2 isoform 1. (338 aa) |
| | PNPT1 | Polyribonucleotide nucleotidyltransferase 1, mitochondrial; RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (By simi [...] (785 aa) |
| | SUCLG1 | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (346 aa) |
| | NT5DC4 | NT5DC4 isoform 1. (420 aa) |
| | CNOT11 | CCR4-NOT transcription complex subunit 11. (510 aa) |
| | ENSPPYP00000013377 | annotation not available (372 aa) |
| | TTC38 | Tetratricopeptide repeat protein 38; Belongs to the TTC38 family. (469 aa) |
| | LOC100458762 | CMP/dCMP-type deaminase domain-containing protein. (211 aa) |
| | NUDT17 | Nudix hydrolase 17. (328 aa) |
| | CSDE1 | Cold shock domain containing E1. (798 aa) |
| | DPYD | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine (By similarity). (1023 aa) |
| | DNASE2B | Deoxyribonuclease 2 beta. (361 aa) |
| | PDE4B | Phosphodiesterase. (736 aa) |
| | MAGOH | Mago homolog, exon junction complex subunit. (146 aa) |
| | TUT4 | ZCCHC11 isoform 3. (1640 aa) |
| | NT5C1A | 5'-nucleotidase, cytosolic IA. (368 aa) |
| | PABPC4 | Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (660 aa) |
| | ZC3H12A | ZC3H12A isoform 1. (599 aa) |
| | CR201_G0015676 | THRAP3 isoform 1. (560 aa) |
| | AGO3 | Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa) |
| | AGO1 | Argonaute RISC component 1; Belongs to the argonaute family. (857 aa) |
| | AGO4 | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (854 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | PATL1 | Protein PAT1 homolog 1; RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly (By similarity); Belongs to the PAT1 family. (770 aa) |
| | PDE2A | Phosphodiesterase. (939 aa) |
| | ACAT1 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa) |
| | GDA | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. (470 aa) |
| | TUT7 | ZCCHC6 isoform 2. (1494 aa) |
| | NCBP1 | Nuclear cap binding protein subunit 1. (790 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3003 aa) |
| | RBM7 | RNA binding motif protein 7. (267 aa) |
| | SIDT2 | SIDT2 isoform 3. (776 aa) |
| | DCPS | DCPS isoform 2. (337 aa) |
| | DCP1B | mRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (By similarity). (536 aa) |
| | APOBEC1 | APOBEC1 isoform 1. (248 aa) |
| | AICDA | Activation induced cytidine deaminase. (196 aa) |
| | MAGOHB | Mago homolog B, exon junction complex subunit. (148 aa) |
| | LRPPRC | LRPPRC isoform 5. (803 aa) |
| | ZCCHC7 | ZCCHC7 isoform 2. (217 aa) |
| | NUDT8 | NUDT8 isoform 3. (236 aa) |
| | SMG9 | SMG9 nonsense mediated mRNA decay factor. (540 aa) |
| | CNOT6 | CCR4-NOT transcription complex subunit 6. (559 aa) |
| | ZPR1 | ZPR1 isoform 1. (459 aa) |
| | CR201_G0042946 | T0152302 isoform 1. (252 aa) |
| | DNASE1L1 | Deoxyribonuclease; Belongs to the DNase I family. (222 aa) |
| | ABCD1 | ABCD1 isoform 1. (710 aa) |
| | TREX2 | TREX2 isoform 5. (236 aa) |
| | APOBEC3G | APOBEC3G isoform 1. (398 aa) |
| | APOBEC3C | Apolipoprotein B mRNA editing enzyme catalytic subunit 3C. (190 aa) |
| | APOBEC3F | DNA dC->dU-editing enzyme APOBEC-3F isoform X1. (382 aa) |
| | UPB1 | Beta-ureidopropionase; Catalyzes a late step in pyrimidine degradation. Converts N- carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide. Likewise, converts N-carbamoyl-beta- aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide; Belongs to the carbon-nitrogen hydrolase superfamily. BUP family. (384 aa) |
| | CECR2 | CECR2 isoform 2. (1440 aa) |
| | PDE9A | Phosphodiesterase. (551 aa) |
| | HELZ2 | HELZ2 isoform 3. (2587 aa) |
| | ADA | Adenosine deaminase. (363 aa) |
| | FITM2 | FITM2 isoform 1. (299 aa) |
| | SAMHD1 | SAMHD1 isoform 1. (626 aa) |
| | AHCY | Adenosylhomocysteinase. (432 aa) |
| | ITPA | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (194 aa) |
| | ENTPD6 | ENTPD6 isoform 6; Belongs to the GDA1/CD39 NTPase family. (483 aa) |
| | XRN2 | 5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (By similarity). (950 aa) |
| | ZFP36 | ZFP36 isoform 1. (216 aa) |
| | CNOT3 | CNOT3 isoform 7. (753 aa) |
| | DHX34 | DHX34 isoform 1. (1143 aa) |
| | ZC3H4 | ZC3H4 isoform 1. (1196 aa) |
| | NANOS2 | Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa) |
