53 items (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LIN7A	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (233 aa)
	DLG2	DLG2 isoform 1. (735 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	MARK2	Non-specific serine/threonine protein kinase. (640 aa)
	DLG5	DLG5 isoform 1; Belongs to the MAGUK family. (1809 aa)
	PARD3	PARD3 isoform 5. (1353 aa)
	CDC42	Cell division cycle 42. (191 aa)
	PATJ	PATJ isoform 4. (1788 aa)
	LRRC7	Leucine rich repeat containing 7. (1537 aa)
	CRB1	Crumbs cell polarity complex component 1. (1406 aa)
	LIN7B	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (207 aa)
	PARD3B	Partitioning defective 3 homolog B isoform X1. (1026 aa)
	CAMSAP3	CAMSAP3 isoform 2. (844 aa)
	ARF4	ADP-ribosylation factor 4; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity); Belongs to the small GTPase superfamily. Arf family. (180 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (473 aa)
	NT5DC2	NT5DC2 isoform 4. (486 aa)
	RHOA	Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (196 aa)
	PDCD6IP	PDCD6IP isoform 2. (945 aa)
	PRKCI	Protein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process [...] (690 aa)
	DLG1	DLG1 isoform 5; Belongs to the MAGUK family. (922 aa)
	OOEP	OOEP isoform 2. (94 aa)
	WDR1	WDR1 isoform 1. (606 aa)
	FAT1	FAT1 isoform 1. (4591 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1030 aa)
	LRRC1	Leucine rich repeat containing 1. (524 aa)
	CRB3	CRB3 isoform 3. (123 aa)
	SYNE4	SYNE4 isoform 6. (404 aa)
	LAMA1	LAMA1 isoform 1. (842 aa)
	MTCL1	MTCL1 isoform 3. (1652 aa)
	FOXJ1	FOXJ1 isoform 1. (421 aa)
	SLC9A3R1	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (357 aa)
	IFT20	IFT20 isoform 6. (158 aa)
	LLGL1	LLGL1 isoform 2. (1051 aa)
	DLG4	DLG4 isoform 3; Belongs to the MAGUK family. (690 aa)
	FOXF1	FOXF1 isoform 1. (380 aa)
	PARD6A	Par-6 family cell polarity regulator alpha. (346 aa)
	MYO9A	MYO9A isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2521 aa)
	TTC8	TTC8 isoform 1. (505 aa)
	CDX2	CDX2 isoform 1. (286 aa)
	CR201_G0002480	LAMA1 isoform 5. (479 aa)
	SYNJ2BP	SYNJ2BP-COX16 isoform 3. (144 aa)
	ERBIN	Erbb2 interacting protein. (1419 aa)
	PDZD11	PDZ domain containing 11. (140 aa)
	DLG3	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (849 aa)
	OPHN1	OPHN1 isoform 1. (802 aa)
	MSN	MSN isoform 6. (577 aa)
	LHX2	LHX2 isoform 2. (406 aa)
	CRB2	CRB2 isoform 2. (637 aa)
	SCRIB	SCRIB isoform 2. (1472 aa)
	ANK1	Ankyrin-1 isoform X1. (1695 aa)
	FSCN1	FSCN1 isoform 3. (444 aa)
	EZR	EZR isoform 1. (586 aa)
	NT5DC3	5'-nucleotidase domain containing 3. (548 aa)

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANK1	EZR	ENSPPYP00000020798	ENSPPYP00000019191	Ankyrin-1 isoform X1.	EZR isoform 1.	0.457
ANK1	MSN	ENSPPYP00000020798	ENSPPYP00000022855	Ankyrin-1 isoform X1.	MSN isoform 6.	0.456
ARF4	MYO9A	ENSPPYP00000015403	ENSPPYP00000007495	ADP-ribosylation factor 4; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity); Belongs to the small GTPase superfamily. Arf family.	MYO9A isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.512
ARF4	TTC8	ENSPPYP00000015403	ENSPPYP00000006886	ADP-ribosylation factor 4; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity); Belongs to the small GTPase superfamily. Arf family.	TTC8 isoform 1.	0.510
CDC42	CRB3	ENSPPYP00000002031	ENSPPYP00000010604	Cell division cycle 42.	CRB3 isoform 3.	0.457
CDC42	DLG4	ENSPPYP00000002031	ENSPPYP00000008885	Cell division cycle 42.	DLG4 isoform 3; Belongs to the MAGUK family.	0.602
CDC42	DLG5	ENSPPYP00000002031	ENSPPYP00000002681	Cell division cycle 42.	DLG5 isoform 1; Belongs to the MAGUK family.	0.443
CDC42	EZR	ENSPPYP00000002031	ENSPPYP00000019191	Cell division cycle 42.	EZR isoform 1.	0.725
CDC42	FSCN1	ENSPPYP00000002031	ENSPPYP00000019428	Cell division cycle 42.	FSCN1 isoform 3.	0.522
CDC42	LIN7A	ENSPPYP00000002031	ENSPPYP00000005475	Cell division cycle 42.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.441
CDC42	LRRC1	ENSPPYP00000002031	ENSPPYP00000018709	Cell division cycle 42.	Leucine rich repeat containing 1.	0.421
CDC42	MSN	ENSPPYP00000002031	ENSPPYP00000022855	Cell division cycle 42.	MSN isoform 6.	0.730
CDC42	MYO9A	ENSPPYP00000002031	ENSPPYP00000007495	Cell division cycle 42.	MYO9A isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.726
CDC42	OPHN1	ENSPPYP00000002031	ENSPPYP00000022866	Cell division cycle 42.	OPHN1 isoform 1.	0.536
CDC42	PARD3	ENSPPYP00000002031	ENSPPYP00000002564	Cell division cycle 42.	PARD3 isoform 5.	0.986
CDC42	PARD6A	ENSPPYP00000002031	ENSPPYP00000008432	Cell division cycle 42.	Par-6 family cell polarity regulator alpha.	0.993
CDC42	PATJ	ENSPPYP00000002031	ENSPPYP00000001500	Cell division cycle 42.	PATJ isoform 4.	0.616
CDC42	PRKCI	ENSPPYP00000002031	ENSPPYP00000015972	Cell division cycle 42.	Protein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process [...]	0.950
CDC42	RHOA	ENSPPYP00000002031	ENSPPYP00000015522	Cell division cycle 42.	Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...]	0.585
CDC42	SCRIB	ENSPPYP00000002031	ENSPPYP00000021255	Cell division cycle 42.	SCRIB isoform 2.	0.639