STRINGSTRING
RAB29 RAB29 ENSPPYP00000000352 ENSPPYP00000000352 STX6 STX6 EVI5 EVI5 VAMP3 VAMP3 Washc2 Washc2 VPS26A VPS26A GBF1 GBF1 VTI1A VTI1A TBC1D10C TBC1D10C SNX32 SNX32 VPS51 VPS51 STX5 STX5 DENND5A DENND5A VPS26B VPS26B GOLT1B GOLT1B ARL1 ARL1 VPS29 VPS29 PHETA1 PHETA1 HEATR5A HEATR5A SNX6 SNX6 VTI1B VTI1B TMEM87A TMEM87A SNX1 SNX1 BAIAP3 BAIAP3 TBC1D10B TBC1D10B VPS35 VPS35 VPS53 VPS53 SGSM2 SGSM2 ANKFY1 ANKFY1 ENSPPYP00000009265 ENSPPYP00000009265 SPAG9 SPAG9 UBE2O UBE2O CLTC CLTC SLC66A2 SLC66A2 RNF126 RNF126 PLEKHJ1 PLEKHJ1 STX10 STX10 TBC1D17 TBC1D17 SNX5 SNX5 STX16 STX16 ARFRP1 ARFRP1 TRAPPC10 TRAPPC10 CLTCL1 CLTCL1 TBC1D10A TBC1D10A GGA1 GGA1 PHETA2 PHETA2 GCC2 GCC2 CR201_G0003005 CR201_G0003005 VPS54 VPS54 PREPL PREPL HEATR5B HEATR5B EHD3 EHD3 WASHC1 WASHC1 PIKFYVE PIKFYVE RBSN RBSN RAB7A RAB7A TBC1D23 TBC1D23 TBC1D5 TBC1D5 RAB6B RAB6B RHOBTB3 RHOBTB3 VPS52 VPS52 SNX8 SNX8 YKT6 YKT6 VPS50 VPS50 DENND2A DENND2A RGP1 RGP1 RIC1 RIC1 SNX12 SNX12 ERC1 ERC1 TRIM27 TRIM27 TMEM87B TMEM87B SNX2 SNX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAB29Ras-related protein Rab-7L1; The small GTPases Rab are key regulators in vesicle trafficking (By similarity). Essential for maintaining the integrity of endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (By similarity). Recruits LRRK2 to the Golgi apparatus and stimulates LRRK2 kinase activity (By similarity). Regulates also neuronal process morphology in the intact cen [...] (203 aa)
ENSPPYP00000000352annotation not available (88 aa)
STX6Syntaxin-6; Involved in intracellular vesicle trafficking. (255 aa)
EVI5Ecotropic viral integration site 5. (810 aa)
VAMP3Vesicle associated membrane protein 3. (100 aa)
Washc2WASH complex subunit 2; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation- promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex prob [...] (1331 aa)
VPS26AVPS26, retromer complex component A. (327 aa)
GBF1GBF1 isoform 1. (1855 aa)
VTI1AVesicle transport through interaction with t-SNAREs 1A. (217 aa)
TBC1D10CTBC1D10C isoform 5. (435 aa)
SNX32Sorting nexin; Involved in several stages of intracellular trafficking. (400 aa)
VPS51VPS51 isoform 3. (303 aa)
STX5STX5 isoform 1; Belongs to the syntaxin family. (355 aa)
DENND5ADENND5A isoform 1. (1191 aa)
VPS26BVacuolar protein sorting-associated protein 26B; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for car [...] (336 aa)
GOLT1BGolgi transport 1B. (138 aa)
ARL1ADP ribosylation factor like GTPase 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
VPS29Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] (182 aa)
PHETA1PH domain containing endocytic trafficking adaptor 1. (247 aa)
HEATR5AHEATR5A isoform 1. (1951 aa)
SNX6Sorting nexin-6, N-terminally processed; Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome- to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile call [...] (389 aa)
VTI1BVesicle transport through interaction with t-SNAREs 1B. (232 aa)
TMEM87ATMEM87A isoform 1. (562 aa)
SNX1Sorting nexin-1; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called en [...] (522 aa)
BAIAP3BAIAP3 isoform 3. (1072 aa)
TBC1D10BTBC1 domain family member 10B. (812 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
VPS53Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized t [...] (770 aa)
SGSM2SGSM2 isoform 3. (1040 aa)
ANKFY1Ankyrin repeat and FYVE domain containing 1. (1170 aa)
ENSPPYP00000009265annotation not available (102 aa)
SPAG9Sperm associated antigen 9. (1307 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (1293 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
SLC66A2Solute carrier family 66 member 2. (271 aa)
RNF126RNF126 isoform 1. (240 aa)
PLEKHJ1PLEKHJ1 isoform 1. (149 aa)
STX10STX10 isoform 6; Belongs to the syntaxin family. (249 aa)
TBC1D17TBC1 domain family member 17. (648 aa)
SNX5Sorting nexin; Involved in several stages of intracellular trafficking. (404 aa)
STX16STX16-NPEPL1 isoform 1; Belongs to the syntaxin family. (308 aa)
ARFRP1ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. (201 aa)
TRAPPC10TRAPPC10 isoform 2. (1259 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1640 aa)
TBC1D10ATBC1 domain family member 10A. (503 aa)
GGA1GGA1 isoform 1. (634 aa)
PHETA2PH domain containing endocytic trafficking adaptor 2. (259 aa)
GCC2GCC2 isoform 3. (1686 aa)
CR201_G0003005T0009947 isoform 1. (1278 aa)
VPS54VPS54 subunit of GARP complex. (977 aa)
PREPLProlyl endopeptidase-like; Serine peptidase whose precise substrate specificity remains unclear (By similarity). Does not cleave peptides after a arginine or lysine residue (By similarity). Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex (By similarity). May play a role in the regulation of synaptic vesicle exocytosis (By similarity). (705 aa)
HEATR5BHEATR5B isoform 1. (1991 aa)
EHD3EHD3 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa)
WASHC1WAS protein family homolog 1. (467 aa)
PIKFYVEPIKFYVE isoform 1. (2088 aa)
RBSNRabenosyn, RAB effector. (784 aa)
RAB7ARas-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (208 aa)
TBC1D23TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP- 1 (By similarity). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outg [...] (699 aa)
TBC1D5TBC1D5 isoform 1. (784 aa)
RAB6BRAB6B, member RAS oncogene family. (208 aa)
RHOBTB3RHOBTB3 isoform 7. (548 aa)
VPS52VPS52 isoform 4. (723 aa)
SNX8Sorting nexin 8. (465 aa)
YKT6YKT6 v-SNARE homolog; Belongs to the synaptobrevin family. (198 aa)
VPS50VPS50 isoform 2. (964 aa)
DENND2ADENND2A isoform 4. (1009 aa)
RGP1RGP1 homolog, RAB6A GEF complex partner 1. (391 aa)
RIC1RIC1 isoform 3. (1344 aa)
SNX12Sorting nexin 12. (162 aa)
ERC1ELKS/RAB6-interacting/CAST family member 1. (1120 aa)
TRIM27Tripartite motif containing 27. (513 aa)
TMEM87BTransmembrane protein 87B. (554 aa)
SNX2Sorting nexin-2; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called en [...] (523 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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