STRINGSTRING
ATP1B1 ATP1B1 GJA5 GJA5 SLC2A1 SLC2A1 SLC9A1 SLC9A1 AJAP1 AJAP1 VCL VCL CTNNA3 CTNNA3 ANK3 ANK3 OPALIN OPALIN NRAP NRAP CR201_G0031208 CR201_G0031208 PAK1 PAK1 SCN4B SCN4B NECTIN1 NECTIN1 JAM3 JAM3 KCNA5 KCNA5 PKP2 PKP2 PCDH9 PCDH9 AKAP6 AKAP6 ACTN1 ACTN1 TJP1 TJP1 FHOD1 FHOD1 RANGRF RANGRF MYH1 MYH1 FLOT2 FLOT2 JUP JUP KCNJ2 KCNJ2 CDH2 CDH2 ENSPPYP00000024752 ENSPPYP00000024752 FLOT1 FLOT1 DES DES JAM2 JAM2 PIK3CA PIK3CA FGF13 FGF13 RAP2C RAP2C CR201_G0001575 CR201_G0001575 SCRIB SCRIB TMEM65 TMEM65 AFDN AFDN GJA1 GJA1 DSP DSP CTNNA1 CTNNA1 ANK2 ANK2 CR201_G0040907 CR201_G0040907 DLG1 DLG1 RAP2B RAP2B SCN5A SCN5A CTNNB1 CTNNB1 CAV3 CAV3 NECTIN3 NECTIN3 SCN2A SCN2A SCN1A SCN1A SLC8A1 SLC8A1 BAIAP2L2 BAIAP2L2 YWHAH YWHAH TIAM1 TIAM1 CADM4 CADM4 CR201_G0043999 CR201_G0043999 FXYD1 FXYD1 SCN1B SCN1B DSG2 DSG2 DSC2 DSC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATP1B1Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). (303 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
SLC2A1SLC2A1 isoform 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (491 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
AJAP1AJAP1 isoform 1. (404 aa)
VCLVCL isoform 2. (1134 aa)
CTNNA3CTNNA3 isoform 1. (895 aa)
ANK3ANK3 isoform 1. (4275 aa)
OPALINOpalin; Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation. (129 aa)
NRAPNRAP isoform 1. (1729 aa)
CR201_G0031208AHNAK isoform 6. (2337 aa)
PAK1Non-specific serine/threonine protein kinase. (546 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (228 aa)
NECTIN1NECTIN1 isoform 1. (596 aa)
JAM3JAM3 isoform 1. (315 aa)
KCNA5KCNA5 isoform 1; Belongs to the potassium channel family. (602 aa)
PKP2PKP2 isoform 2. (829 aa)
PCDH9PCDH9 isoform 2. (1237 aa)
AKAP6A-kinase anchoring protein 6. (2319 aa)
ACTN1ACTN1 isoform 1. (980 aa)
TJP1TJP1 isoform 1; Belongs to the MAGUK family. (1746 aa)
FHOD1FHOD1 isoform 2. (1162 aa)
RANGRFRANGRF isoform 1. (186 aa)
MYH1Myosin heavy chain 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
JUPJUP isoform 1. (670 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
CDH2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic s [...] (906 aa)
ENSPPYP00000024752annotation not available (109 aa)
FLOT1Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (427 aa)
DESDES isoform 1; Belongs to the intermediate filament family. (153 aa)
JAM2Junctional adhesion molecule 2. (298 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (832 aa)
FGF13Fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). May regulate voltage-gated sodium channels transport and function (By similarity). May also play a role in MAPK signaling (By similarity). [...] (245 aa)
RAP2CRAP2C isoform 1. (144 aa)
CR201_G0001575PGM5 isoform 7; Belongs to the phosphohexose mutase family. (421 aa)
SCRIBSCRIB isoform 2. (1472 aa)
TMEM65TMEM65 isoform 1. (223 aa)
AFDNAFDN isoform 9. (1802 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
DSPDSP isoform 1. (2871 aa)
CTNNA1CTNNA1 isoform 1. (905 aa)
ANK2ANK2 isoform 1. (4018 aa)
CR201_G0040907FGFRL1 isoform 5. (318 aa)
DLG1DLG1 isoform 5; Belongs to the MAGUK family. (922 aa)
RAP2BRAP2B, member of RAS oncogene family. (183 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1523 aa)
CTNNB1CTNNB1 isoform 2. (781 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa)
NECTIN3NECTIN3 isoform 3. (512 aa)
SCN2ASodium channel protein type 2 subunit alpha. (1165 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2009 aa)
SLC8A1SLC8A1 isoform 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
BAIAP2L2BAIAP2L2 isoform 1. (519 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
TIAM1TIAM1 isoform 1. (1591 aa)
CADM4CADM4 isoform 1. (368 aa)
CR201_G0043999SPTBN4 isoform 1. (2409 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (92 aa)
SCN1BSCN1B isoform 1. (218 aa)
DSG2DSG2 isoform 1. (1072 aa)
DSC2DSC2 isoform 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (904 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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