STRINGSTRING
EPB41L3 EPB41L3 ROBO2 ROBO2 CR201_G0002453 CR201_G0002453 SIRT2 SIRT2 C9orf72 C9orf72 KCNQ3 KCNQ3 CNTNAP2 CNTNAP2 NRCAM NRCAM CR201_G0042455 CR201_G0042455 SPOCK1 SPOCK1 CRHBP CRHBP CR201_G0016076 CR201_G0016076 DLG1 DLG1 IQCJ-SCHIP1 IQCJ-SCHIP1 KCNAB1 KCNAB1 SCN2A SCN2A MAP2 MAP2 SCN1A SCN1A ERMN ERMN BIN1 BIN1 UCN UCN SPTBN1 SPTBN1 CNGA3 CNGA3 ADORA2A ADORA2A CLDN5 CLDN5 KCNQ2 KCNQ2 CR201_G0043999 CR201_G0043999 MAG MAG SCN1B SCN1B MBP MBP CNTNAP1 CNTNAP1 MYO1D MYO1D DLG4 DLG4 MAP1A MAP1A KCNC2 KCNC2 SCN8A SCN8A KCNA1 KCNA1 THY1 THY1 DLG2 DLG2 KCNC1 KCNC1 SLC1A2 SLC1A2 DAGLA DAGLA ANK3 ANK3 PARD3 PARD3 UCN3 UCN3 KCNAB2 KCNAB2 TNFRSF1B TNFRSF1B NCMAP NCMAP LRRC7 LRRC7 KCNA2 KCNA2 TRIM46 TRIM46 HAPLN2 HAPLN2 MYOC MYOC NAV1 NAV1 NFASC NFASC CNTN2 CNTN2 GJC2 GJC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EPB41L3EPB41L3 isoform 2. (792 aa)
ROBO2ROBO2 isoform 6. (1384 aa)
CR201_G0002453EPB41L3 isoform 10. (218 aa)
SIRT2NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtu [...] (389 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
KCNQ3KCNQ3 isoform 2; Belongs to the potassium channel family. (872 aa)
CNTNAP2Contactin-associated protein-like 2; Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction. (1285 aa)
NRCAMNRCAM isoform 11. (1253 aa)
CR201_G0042455GABBR1 isoform 2. (710 aa)
SPOCK1SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1. (439 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (282 aa)
CR201_G0016076MAP1B isoform 1. (1431 aa)
DLG1DLG1 isoform 5; Belongs to the MAGUK family. (922 aa)
IQCJ-SCHIP1Schwannomin-interacting protein 1 isoform X2. (460 aa)
KCNAB1Potassium voltage-gated channel subfamily A member regulatory beta subunit 1. (401 aa)
SCN2ASodium channel protein type 2 subunit alpha. (1165 aa)
MAP2Microtubule-associated protein. (1770 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2009 aa)
ERMNErmin; Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity). (284 aa)
BIN1BIN1 isoform 9. (517 aa)
UCNUCN isoform 1. (129 aa)
SPTBN1Spectrin beta chain; Belongs to the spectrin family. (2342 aa)
CNGA3Cyclic nucleotide gated channel subunit alpha 3. (694 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
KCNQ2KCNQ2 isoform 1; Belongs to the potassium channel family. (778 aa)
CR201_G0043999SPTBN4 isoform 1. (2409 aa)
MAGMAG isoform 1. (627 aa)
SCN1BSCN1B isoform 1. (218 aa)
MBPMBP isoform 10. (304 aa)
CNTNAP1Contactin associated protein 1. (1384 aa)
MYO1DMYO1D isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1006 aa)
DLG4DLG4 isoform 3; Belongs to the MAGUK family. (690 aa)
MAP1AMAP1A isoform 2. (3039 aa)
KCNC2KCNC2 isoform 1; Belongs to the potassium channel family. (612 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1825 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
THY1Thy-1 cell surface antigen. (161 aa)
DLG2DLG2 isoform 1. (735 aa)
KCNC1Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family. (585 aa)
SLC1A2Amino acid transporter. (574 aa)
DAGLADiacylglycerol lipase alpha. (1043 aa)
ANK3ANK3 isoform 1. (4275 aa)
PARD3PARD3 isoform 5. (1353 aa)
UCN3UCN3 isoform 1. (161 aa)
KCNAB2KCNAB2 isoform 13. (367 aa)
TNFRSF1BTNFRSF1B isoform 2. (455 aa)
NCMAPNon-compact myelin associated protein. (102 aa)
LRRC7Leucine rich repeat containing 7. (1537 aa)
KCNA2KCNA2 isoform 1; Belongs to the potassium channel family. (356 aa)
TRIM46Tripartite motif containing 46. (759 aa)
HAPLN2Hyaluronan and proteoglycan link protein 2. (340 aa)
MYOCMYOC isoform 2. (490 aa)
NAV1NAV1 isoform 2. (2051 aa)
NFASCNFASC isoform 1. (1342 aa)
CNTN2CNTN2 isoform 10. (1039 aa)
GJC2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (441 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.