STRINGSTRING
FOXM1 FOXM1 CR201_G0026161 CR201_G0026161 CR201_G0005810 CR201_G0005810 HINFP HINFP NPAT NPAT TAF10 TAF10 WEE1 WEE1 USH1C USH1C CCND1 CCND1 CR201_G0045870 CR201_G0045870 PPP2R2D PPP2R2D CACUL1 CACUL1 FBXL15 FBXL15 CCNJ CCNJ CDK1 CDK1 CCNY CCNY MASTL MASTL RCC1 RCC1 KHDRBS1 KHDRBS1 CR201_G0041907 CR201_G0041907 NASP NASP CDC7 CDC7 ENSA ENSA CKS1B CKS1B IQGAP3 IQGAP3 PBX1 PBX1 RHOU RHOU ENSPPYP00000009928 ENSPPYP00000009928 CDC27 CDC27 CR201_G0002293 CR201_G0002293 BCL2 BCL2 CTDP1 CTDP1 CDC34 CDC34 FBXL12 FBXL12 DNM2 DNM2 BRD4 BRD4 CCNE1 CCNE1 ENSPPYP00000011173 ENSPPYP00000011173 MARK4 MARK4 BRSK1 BRSK1 UBE2S UBE2S ENSPPYP00000011752 ENSPPYP00000011752 ZNF324 ZNF324 CHMP2A CHMP2A PLCB1 PLCB1 CDC25B CDC25B E2F1 E2F1 CHMP4B CHMP4B UBE2C UBE2C AURKA AURKA APP APP PIM2 PIM2 CCNB3 CCNB3 PHF8 PHF8 CUL4B CUL4B USP26 USP26 ENSPPYP00000023240 ENSPPYP00000023240 CKS2 CKS2 TFDP1 TFDP1 ZPR1 ZPR1 CKS2-2 CKS2-2 EZH2 EZH2 NES NES ID4 ID4 TAF2 TAF2 CR201_G0022282 CR201_G0022282 CNTD2 CNTD2 GFI1 GFI1 CIT CIT BACH1 BACH1 CHEK2 CHEK2 ANAPC1 ANAPC1 CALM1-2 CALM1-2 CR201_G0003538 CR201_G0003538 SPAST SPAST SPDYA SPDYA E2F6 E2F6 KLF11 KLF11 CLASP1 CLASP1 CDK15 CDK15 USP37 USP37 CUL3 CUL3 RPL24 RPL24 CDC25A CDC25A CLASP2 CLASP2 TRIM71 TRIM71 TACC3 TACC3 CCNI CCNI CCNG2 CCNG2 EIF4E EIF4E PPP3CA PPP3CA CCNA2 CCNA2 FBXL7 FBXL7 SKP2 SKP2 PLK2 PLK2 CCNB1 CCNB1 FBXL17 FBXL17 CCNI2 CCNI2 NEUROG1 NEUROG1 FBXL21 FBXL21 CDC23 CDC23 CDC25C CDC25C CCNJL CCNJL ENSPPYP00000018058 ENSPPYP00000018058 E2F3 E2F3 CDKN1A CDKN1A CCND3 CCND3 TPD52L1 TPD52L1 LATS1 LATS1 CDK6 CDK6 CDK14 CDK14 DBF4 DBF4 ABCB1 ABCB1 CDK5 CDK5 LZTS1 LZTS1 CHMP7 CHMP7 EIF4EBP1 EIF4EBP1 LOC100455662 LOC100455662 CCNE2 CCNE2 MYC MYC MELK MELK RPS6 RPS6 SMC5 SMC5 ENSPPYP00000021673 ENSPPYP00000021673 PPP6C PPP6C ANAPC2 ANAPC2 LOC100457325 LOC100457325 CDK16 CDK16 E2F7 E2F7 RB1 RB1 FBXL3 FBXL3 CUL4A CUL4A CDC16 CDC16 CDKN3 CDKN3 MNAT1 MNAT1 ESRRB ESRRB CDK17 CDK17 POLE POLE LATS2 LATS2 CCNA1 CCNA1 CALM1 CALM1 GPR132 GPR132 BUB1B BUB1B TMOD3 TMOD3 ARPP19 ARPP19 CCNB2 CCNB2 FBXL22 FBXL22 CCNF CCNF PKMYT1 PKMYT1 PLK1 PLK1 LCMT1 LCMT1 KDM8 KDM8 E2F4 E2F4 PPM1D PPM1D CDK3 CDK3 BIRC5 BIRC5 SIRT7 SIRT7 RPS6KB1 RPS6KB1 CDK4 CDK4 CDK2 CDK2 ACVR1B ACVR1B WNT10B WNT10B BCAT1 BCAT1 EPS8 EPS8 CDKN1B CDKN1B CCND2 CCND2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOXM1FOXM1 isoform 4. (763 aa)
CR201_G0026161USH1C isoform 8. (559 aa)
CR201_G0005810CHEK1 isoform 2; Belongs to the protein kinase superfamily. (441 aa)
HINFPHistone H4 transcription factor. (517 aa)
NPATNPAT isoform 1. (1416 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
WEE1Wee1-like protein kinase. (646 aa)
USH1CUSH1C isoform 9. (403 aa)
CCND1G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (173 aa)
CR201_G0045870BRSK2 isoform 12. (655 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (420 aa)
CACUL1CACUL1 isoform 2; Belongs to the cullin family. (340 aa)
FBXL15FBXL15 isoform 4. (388 aa)
CCNJCCNJ isoform 1; Belongs to the cyclin family. (420 aa)
CDK1Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] (297 aa)
CCNYCCNY isoform 4; Belongs to the cyclin family. (341 aa)
MASTLMASTL isoform 1. (878 aa)
RCC1RCC1 isoform 5. (452 aa)
KHDRBS1KHDRBS1 isoform 2. (547 aa)
CR201_G0041907Serine/threonine-protein kinase PLK. (286 aa)
NASPNuclear autoantigenic sperm protein. (787 aa)
CDC7Cell division cycle 7. (574 aa)
ENSAEndosulfine alpha. (137 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
IQGAP3IQGAP3 isoform 2. (1594 aa)
PBX1PBX homeobox 1. (430 aa)
RHOURas homolog family member U. (258 aa)
ENSPPYP00000009928annotation not available (353 aa)
CDC27CDC27 isoform 1. (824 aa)
CR201_G0002293RBBP8 isoform 3. (794 aa)
BCL2BCL2 isoform 1. (238 aa)
CTDP1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (956 aa)
CDC34CDC34 isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (217 aa)
FBXL12F-box and leucine rich repeat protein 12. (326 aa)
DNM2DNM2 isoform 6; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (866 aa)
BRD4Bromodomain containing 4. (1363 aa)
CCNE1CCNE1 isoform 1; Belongs to the cyclin family. (410 aa)
ENSPPYP00000011173annotation not available (222 aa)
MARK4Non-specific serine/threonine protein kinase. (744 aa)
BRSK1BRSK1 isoform 1. (680 aa)
UBE2SUBE2S isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (222 aa)
ENSPPYP00000011752annotation not available (89 aa)
ZNF324Zinc finger protein 324. (553 aa)
CHMP2ACHMP2A isoform 1. (222 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1215 aa)
CDC25BCell division cycle 25B. (580 aa)
E2F1E2F1 isoform 1. (361 aa)
CHMP4BCHMP4B isoform 1. (210 aa)
UBE2CUbiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
AURKAAURKA isoform 10; Belongs to the protein kinase superfamily. (404 aa)
APPAPP isoform 3. (736 aa)
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (311 aa)
CCNB3CCNB3 isoform 3; Belongs to the cyclin family. (1394 aa)
PHF8PHF8 isoform 2. (986 aa)
CUL4BCUL4B isoform 4; Belongs to the cullin family. (843 aa)
USP26Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (915 aa)
ENSPPYP00000023240annotation not available (289 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
TFDP1Transcription factor. (410 aa)
ZPR1ZPR1 isoform 1. (459 aa)
CKS2-2CDC28 protein kinase regulatory subunit 2. (79 aa)
EZH2EZH2 isoform 5. (704 aa)
NESNES isoform 1; Belongs to the intermediate filament family. (1632 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
TAF2TATA-box binding protein associated factor 2. (1251 aa)
CR201_G0022282CCNO isoform 1; Belongs to the cyclin family. (235 aa)
CNTD2CNTD2 isoform 5; Belongs to the cyclin family. (201 aa)
GFI1GFI1 isoform 1. (348 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2054 aa)
BACH1BACH1 isoform 5. (736 aa)
CHEK2CHEK2 isoform 5. (520 aa)
ANAPC1ANAPC1 isoform 2. (1855 aa)
CALM1-2Calmodulin 2. (149 aa)
CR201_G0003538MTA3 isoform 5. (496 aa)
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (477 aa)
SPDYASpeedy/RINGO cell cycle regulator family member A. (313 aa)
E2F6E2F6 isoform 3. (246 aa)
KLF11Kruppel like factor 11. (512 aa)
CLASP1CLASP1 isoform 3. (1537 aa)
CDK15CDK15 isoform 1; Belongs to the protein kinase superfamily. (435 aa)
USP37Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (895 aa)
CUL3CUL3 isoform 1; Belongs to the cullin family. (768 aa)
RPL24RPL24 isoform 2. (173 aa)
CDC25ACell division cycle 25A. (524 aa)
CLASP2CLASP2 isoform 2. (1505 aa)
TRIM71TRIM71 isoform 1. (867 aa)
TACC3TACC3 isoform 2. (822 aa)
CCNICCNI isoform 1; Belongs to the cyclin family. (375 aa)
CCNG2CCNG2 isoform 1; Belongs to the cyclin family. (344 aa)
EIF4EEIF4E isoform 1; Belongs to the eukaryotic initiation factor 4E family. (181 aa)
PPP3CASerine/threonine-protein phosphatase. (514 aa)
CCNA2CCNA2 isoform 1; Belongs to the cyclin family. (432 aa)
FBXL7F-box and leucine rich repeat protein 7. (444 aa)
SKP2SKP2 isoform 1. (410 aa)
PLK2Serine/threonine-protein kinase PLK2; Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 an [...] (685 aa)
CCNB1CCNB1 isoform 1; Belongs to the cyclin family. (433 aa)
FBXL17FBXL17 isoform 1. (751 aa)
CCNI2Cyclin I family member 2; Belongs to the cyclin family. (369 aa)
NEUROG1NEUROG1 isoform 1. (237 aa)
FBXL21F-box and leucine-rich repeat protein 21. (377 aa)
CDC23Cell division cycle 23. (597 aa)
CDC25CCell division cycle 25C. (473 aa)
CCNJLCCNJL isoform 1; Belongs to the cyclin family. (434 aa)
ENSPPYP00000018058annotation not available (112 aa)
E2F3E2F3 isoform 2. (427 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
CCND3CCND3 isoform 1; Belongs to the cyclin family. (292 aa)
TPD52L1TPD52L1 isoform 3. (204 aa)
LATS1Large tumor suppressor kinase 1. (1130 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
CDK14CDK14 isoform 1; Belongs to the protein kinase superfamily. (469 aa)
DBF4DBF4 isoform 1. (673 aa)
ABCB1ABCB1 isoform 4. (1280 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
LZTS1LZTS1 isoform 1. (544 aa)
CHMP7Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway. (453 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
LOC100455662Calmodulin-alpha-like. (149 aa)
CCNE2CCNE2 isoform 1; Belongs to the cyclin family. (401 aa)
MYCMYC isoform 1. (453 aa)
MELKNon-specific serine/threonine protein kinase. (651 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
SMC5SMC5 isoform 1. (1041 aa)
ENSPPYP00000021673annotation not available (244 aa)
PPP6CSerine/threonine-protein phosphatase. (305 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa)
LOC100457325Transcription factor Dp-1. (408 aa)
CDK16CDK16 isoform 3. (496 aa)
E2F7E2F transcription factor 7. (908 aa)
RB1RB1 isoform 1. (928 aa)
FBXL3F-box and leucine rich repeat protein 3. (428 aa)
CUL4ACUL4A isoform 5; Belongs to the cullin family. (759 aa)
CDC16CDC16 isoform 4. (575 aa)
CDKN3Cyclin-dependent kinase inhibitor 3; May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. (212 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (288 aa)
ESRRBESRRB isoform 5. (438 aa)
CDK17Cyclin dependent kinase 17. (523 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2039 aa)
LATS2Non-specific serine/threonine protein kinase. (1098 aa)
CCNA1CCNA1 isoform 3; Belongs to the cyclin family. (464 aa)
CALM1Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa)
GPR132GPR132 isoform 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
BUB1BMitotic checkpoint serine/threonine-protein kinase BUB1 beta. (1050 aa)
TMOD3TMOD3 isoform 2. (352 aa)
ARPP19ARPP19 isoform 1; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (120 aa)
CCNB2CCNB2 isoform 1; Belongs to the cyclin family. (398 aa)
FBXL22FBXL22 isoform 1. (234 aa)
CCNFCCNF isoform 1; Belongs to the cyclin family. (783 aa)
PKMYT1PKMYT1 isoform 10; Belongs to the protein kinase superfamily. (499 aa)
PLK1Serine/threonine-protein kinase PLK. (603 aa)
LCMT1Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (334 aa)
KDM8Lysine demethylase 8. (416 aa)
E2F4E2F transcription factor 4. (411 aa)
PPM1DPPM1D isoform 2. (605 aa)
CDK3CDK3 isoform 1; Belongs to the protein kinase superfamily. (305 aa)
BIRC5Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (142 aa)
SIRT7SIRT7 isoform 2. (195 aa)
RPS6KB1T0040019 isoform 1. (525 aa)
CDK4CDK4 isoform 2; Belongs to the protein kinase superfamily. (317 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (453 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (317 aa)
BCAT1Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (453 aa)
EPS8Epidermal growth factor receptor kinase substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and acti [...] (824 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
CCND2CCND2 isoform 1; Belongs to the cyclin family. (289 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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