STRINGSTRING
ATP2B4 ATP2B4 PTGS2 PTGS2 FASLG FASLG SELE SELE CR201_G0042066 CR201_G0042066 CHRNB2 CHRNB2 LRP8 LRP8 SLC2A1 SLC2A1 CR201_G0030157 CR201_G0030157 MYOF MYOF SORBS1 SORBS1 MS4A1 MS4A1 MS4A4A MS4A4A LRP4 LRP4 KIF18A KIF18A CAVIN3 CAVIN3 STIM1 STIM1 NEU3 NEU3 CBL CBL MYO1A MYO1A SELPLG SELPLG CORO1C CORO1C ORAI1 ORAI1 SCARB1 SCARB1 TRPC4 TRPC4 HTR2A HTR2A AKAP6 AKAP6 CHRNA7 CHRNA7 CHRNA3 CHRNA3 IGF1R IGF1R CLN3 CLN3 MAPK3 MAPK3 ITGAM ITGAM CDH15 CDH15 RANGRF RANGRF FLOT2 FLOT2 SKAP1 SKAP1 CAVIN1 CAVIN1 PLPP2 PLPP2 PRTN3 PRTN3 INSR INSR FXYD1 FXYD1 LYPD4 LYPD4 LIPE LIPE CD177 CD177 ENSPPYP00000011254 ENSPPYP00000011254 TEX101 TEX101 EHD2 EHD2 HCK HCK SRC SRC PTGIS PTGIS ITGB2 ITGB2 MLC1 MLC1 ENSPPYP00000013398 ENSPPYP00000013398 MAL MAL CR201_G0049459 CR201_G0049459 ADD2 ADD2 TFPI TFPI CAVIN2 CAVIN2 CAV3 CAV3 PRKAR2A PRKAR2A GASK1A GASK1A CTNNB1 CTNNB1 SCN5A SCN5A TGFBR2 TGFBR2 SLC6A3 SLC6A3 ENSPPYP00000017286 ENSPPYP00000017286 F2R F2R EFNA5 EFNA5 CTNNA1 CTNNA1 ADRA1B ADRA1B LCP2 LCP2 ADTRP ADTRP TREM2 TREM2 BVES BVES SMPD2 SMPD2 EZR EZR ADCYAP1R1 ADCYAP1R1 AQP1 AQP1 CD36 CD36 CAV2 CAV2 CAV1 CAV1 KCND2 KCND2 NOS3 NOS3 DLC1 DLC1 ADRA1A ADRA1A HAS2 HAS2 ADCY8 ADCY8 JAK2 JAK2 PTCH1 PTCH1 CAVIN4 CAVIN4 HDAC6 HDAC6 MAPK1 MAPK1 PLVAP PLVAP LRRK2 LRRK2 ENSPPYP00000024124 ENSPPYP00000024124 FLOT1 FLOT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1110 aa)
PTGS2PTGS2 isoform 1. (604 aa)
FASLGFASLG isoform 1; Belongs to the tumor necrosis factor family. (280 aa)
SELESELE isoform 3. (601 aa)
CR201_G0042066C1orf226 isoform 2. (695 aa)
CHRNB2CHRNB2 isoform 2. (518 aa)
LRP8LRP8 isoform 1. (955 aa)
SLC2A1SLC2A1 isoform 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (491 aa)
CR201_G0030157KCNMA1 isoform 84. (265 aa)
MYOFMYOF isoform 2. (1936 aa)
SORBS1SORBS1 isoform 10. (1292 aa)
MS4A1Membrane spanning 4-domains A1. (297 aa)
MS4A4AMS4A4A isoform 1. (182 aa)
LRP4LRP4 isoform 2. (1900 aa)
KIF18AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (880 aa)
CAVIN3Caveolae associated protein 3. (261 aa)
STIM1Stromal interaction molecule 1. (685 aa)
NEU3NEU3 isoform 2. (404 aa)
CBLCbl proto-oncogene. (905 aa)
MYO1AMYO1A isoform 4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (827 aa)
SELPLGSELPLG isoform 1. (402 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (434 aa)
ORAI1ORAI1 isoform 1. (297 aa)
SCARB1SCARB1 isoform 7; Belongs to the CD36 family. (471 aa)
TRPC4TRPC4 isoform 8. (893 aa)
HTR2AHTR2A isoform 2. (353 aa)
AKAP6A-kinase anchoring protein 6. (2319 aa)
CHRNA7CHRNA7 isoform 8. (502 aa)
CHRNA3Cholinergic receptor nicotinic alpha 3 subunit. (505 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
CLN3Battenin. (438 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa)
ITGAMITGAM isoform 1; Belongs to the integrin alpha chain family. (1014 aa)
CDH15CDH15 isoform 1; Cadherins are calcium-dependent cell adhesion proteins. (676 aa)
RANGRFRANGRF isoform 1. (186 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
SKAP1SKAP1 isoform 2. (347 aa)
CAVIN1CAVIN1 isoform 1. (233 aa)
PLPP2PLPP2 isoform 1. (270 aa)
PRTN3PRTN3 isoform 2; Belongs to the peptidase S1 family. (256 aa)
INSRTyrosine-protein kinase receptor. (1305 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (92 aa)
LYPD4LYPD4 isoform 1. (151 aa)
LIPELIPE isoform 2. (1068 aa)
CD177CD177 isoform 1. (437 aa)
ENSPPYP00000011254CD177 antigen. (166 aa)
TEX101TEX101 isoform 1. (267 aa)
EHD2EHD2 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (605 aa)
HCKTyrosine-protein kinase. (449 aa)
SRCTyrosine-protein kinase. (553 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (498 aa)
ITGB2Integrin beta. (768 aa)
MLC1MLC1 isoform 1. (426 aa)
ENSPPYP00000013398annotation not available (195 aa)
MALMal, T cell differentiation protein. (153 aa)
CR201_G0049459CD8A isoform 1. (272 aa)
ADD2Beta-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity). Belongs to the aldolase class II family. Adducin subfamily. (726 aa)
TFPITissue factor pathway inhibitor. (304 aa)
CAVIN2Caveolae associated protein 2. (425 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (382 aa)
GASK1AFAM198A isoform 1. (506 aa)
CTNNB1CTNNB1 isoform 2. (781 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1523 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (576 aa)
ENSPPYP00000017286annotation not available (283 aa)
F2RF2R isoform 1; Belongs to the G-protein coupled receptor 1 family. (389 aa)
EFNA5EFNA5 isoform 1; Belongs to the ephrin family. (228 aa)
CTNNA1CTNNA1 isoform 1. (905 aa)
ADRA1BADRA1B isoform 3. (517 aa)
LCP2LCP2 isoform 3. (534 aa)
ADTRPADTRP isoform 2. (256 aa)
TREM2TREM2 isoform 1. (202 aa)
BVESBlood vessel epicardial substance. (360 aa)
SMPD2SMPD2 isoform 1. (577 aa)
EZREZR isoform 1. (586 aa)
ADCYAP1R1ADCYAP1R1 isoform 1; Belongs to the G-protein coupled receptor 2 family. (487 aa)
AQP1Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (323 aa)
CD36CD36 isoform 15; Belongs to the CD36 family. (472 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
CAV1Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...] (178 aa)
KCND2KCND2 isoform 1; Belongs to the potassium channel family. (630 aa)
NOS3NOS3 isoform 2. (833 aa)
DLC1DLC1 isoform 1. (1515 aa)
ADRA1AAdrenoceptor alpha 1A. (427 aa)
HAS2HAS2 isoform 1. (511 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1132 aa)
PTCH1PTCH1 isoform 7. (1429 aa)
CAVIN4CAVIN4 isoform 1. (356 aa)
HDAC6HDAC6 isoform 2. (1208 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (158 aa)
PLVAPPLVAP isoform 1. (429 aa)
LRRK2LRRK2 isoform 3. (1560 aa)
ENSPPYP00000024124annotation not available (225 aa)
FLOT1Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (427 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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