STRINGSTRING
PLD2 PLD2 PNPLA3 PNPLA3 SOCS7 SOCS7 PITPNM1 PITPNM1 MTMR4 MTMR4 FAM126B FAM126B PIP4K2B PIP4K2B PIK3CA PIK3CA TAZ TAZ MTMR1 MTMR1 MTM1 MTM1 OCRL OCRL DGAT2L6 DGAT2L6 AWAT2 AWAT2 PCYT1B PCYT1B BMX BMX PIGA PIGA HDHD5 HDHD5 AGPAT2 AGPAT2 FAM102A FAM102A DPM2 DPM2 PIP5KL1 PIP5KL1 SLC44A1 SLC44A1 PGAP4 PGAP4 PIP5K1B PIP5K1B PIGO PIGO IMPA1-2 IMPA1-2 DGAT1 DGAT1 GPAA1 GPAA1 EFR3A EFR3A IMPA1 IMPA1 FABP5 FABP5 IMPAD1 IMPAD1 GPAT4 GPAT4 LPL LPL MTMR7 MTMR7 AGPAT5 AGPAT5 PIK3CG PIK3CG DGKB DGKB AGMO AGMO DKFZp468N1212 DKFZp468N1212 ENSPPYP00000019554 ENSPPYP00000019554 MOGAT3 MOGAT3 AGPAT4 AGPAT4 SYNJ2 SYNJ2 FIG4 FIG4 IP6K3 IP6K3 AGPAT1 AGPAT1 SLC44A4 SLC44A4 ENSPPYP00000018135 ENSPPYP00000018135 LPCAT1 LPCAT1 ACSL1 ACSL1 INPP4B INPP4B PYURF PYURF CDS1 CDS1 GPAT3 GPAT3 CWH43 CWH43 PI4K2B PI4K2B DGKQ DGKQ PIGG PIGG PIGZ PIGZ PIGX PIGX PCYT1A PCYT1A DGKG DGKG LIPH LIPH PLD1 PLD1 PLSCR1 PLSCR1 PIK3CB PIK3CB PIK3R4 PIK3R4 ABHD5 ABHD5 SACM1L SACM1L IP6K2 IP6K2 IP6K1 IP6K1 CISH CISH MTMR14 MTMR14 TAMM41 TAMM41 DGKD DGKD INPP5D INPP5D ENSPPYP00000014776 ENSPPYP00000014776 PIKFYVE PIKFYVE PGAP1 PGAP1 C2orf66 C2orf66 INPP1 INPP1 SH3YL1 SH3YL1 LPIN1 LPIN1 SELENOI SELENOI LCLAT1 LCLAT1 MORN2 MORN2 PIGF PIGF SOCS5 SOCS5 TTC7A TTC7A TMEM150A TMEM150A INPP4A INPP4A CR201_G0055610 CR201_G0055610 PI4KA PI4KA PLA2G6 PLA2G6 PRR14L PRR14L PISD PISD INPP5J INPP5J MTMR3 MTMR3 AGPAT3 AGPAT3 PIGP PIGP SYNJ1 SYNJ1 PCK1 PCK1 DPM1 DPM1 PIGT PIGT LPIN3 LPIN3 SLA2 SLA2 PIGU PIGU CDS2 CDS2 CRLS1 CRLS1 GNPAT GNPAT MBOAT7 MBOAT7 PLA2G4C PLA2G4C ITPKC ITPKC CR201_G0037390 CR201_G0037390 SLC27A1 SLC27A1 ABHD8 ABHD8 SLC44A2 SLC44A2 CR201_G0044279 CR201_G0044279 SOCS6 SOCS6 PIGN PIGN PIK3C3 PIK3C3 ABHD3 ABHD3 LPIN2 LPIN2 MPPE1 MPPE1 CR201_G0051275 CR201_G0051275 PCYT2 PCYT2 PGS1 PGS1 SOCS3 SOCS3 PGAP3 PGAP3 BECN1 BECN1 DGKE DGKE PIGS PIGS DHRS7B DHRS7B PEMT PEMT PIGL PIGL PIK3R6 PIK3R6 PLSCR3 PLSCR3 PITPNM3 PITPNM3 ALOX15 ALOX15 INPP5K INPP5K CR201_G0047047 CR201_G0047047 PLCG2 PLCG2 VAC14 VAC14 PLA2G15 PLA2G15 LCAT LCAT LPCAT2 LPCAT2 CDIPT CDIPT CLN3 CLN3 SMG1 SMG1 SOCS1 SOCS1 PIGQ PIGQ PIGB PIGB ITPKA ITPKA LPCAT4 LPCAT4 TTC7B TTC7B PIGH PIGH ATG14 ATG14 PCK2 PCK2 AJUBA AJUBA ABHD4 ABHD4 DGKH DGKH MTMR6 MTMR6 PITPNM2 PITPNM2 CHPT1 CHPT1 SOCS2 SOCS2 PIP4K2C PIP4K2C ENSPPYP00000005310 ENSPPYP00000005310 DGKA DGKA ETNK1 ETNK1 LPCAT3 LPCAT3 APOA1 APOA1 ATM ATM MTMR2 MTMR2 UVRAG UVRAG DGAT2 DGAT2 MOGAT2 MOGAT2 INPPL1 INPPL1 PGAP2 PGAP2 PIK3C2A PIK3C2A CR201_G0010942 CR201_G0010942 PTPMT1 PTPMT1 CHKA CHKA PNPLA2 PNPLA2 PTDSS2 PTDSS2 INPP5F INPP5F ENSPPYP00000003091 ENSPPYP00000003091 PI4K2A PI4K2A PLCE1 PLCE1 PTEN PTEN IPMK IPMK CHAT CHAT PIP4K2A PIP4K2A PIK3CD PIK3CD PIGV PIGV MFSD2A MFSD2A PIK3R3 PIK3R3 SLC44A5 SLC44A5 PIGK PIGK SLC44A3 SLC44A3 FAM102B FAM102B CEPT1 CEPT1 PIP5K1A PIP5K1A PI4KB PI4KB DPM3 DPM3 PIGM PIGM PIGC PIGC CR201_G0021695 CR201_G0021695 RGSL1 RGSL1 PLA2G4A PLA2G4A ETNK2 ETNK2 PIK3C2B PIK3C2B LPGAT1 LPGAT1 BPNT1 BPNT1 ITPKB ITPKB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PLD2Phospholipase. (933 aa)
PNPLA3PNPLA3 isoform 3. (283 aa)
SOCS7SOCS7 isoform 2. (578 aa)
PITPNM1PITPNM1 isoform 1. (1267 aa)
MTMR4Myotubularin related protein 4. (1227 aa)
FAM126BProtein FAM126B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. (338 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (435 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (832 aa)
TAZTafazzin family protein; Some isoforms may be involved in cardiolipin metabolism. (262 aa)
MTMR1MTMR1 isoform 9. (685 aa)
MTM1Myotubularin; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not fo [...] (603 aa)
OCRLOCRL isoform 3. (855 aa)
DGAT2L6DGAT2L6 isoform 1. (336 aa)
AWAT2Acyl-CoA wax alcohol acyltransferase 2. (333 aa)
PCYT1BPCYT1B isoform 3. (302 aa)
BMXTyrosine-protein kinase. (675 aa)
PIGAPhosphatidylinositol glycan anchor biosynthesis class A. (484 aa)
HDHD5HDHD5 isoform 2. (390 aa)
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (278 aa)
FAM102AFAM102A isoform 1. (379 aa)
DPM2Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family. (75 aa)
PIP5KL1PIP5KL1 isoform 1. (439 aa)
SLC44A1SLC44A1 isoform 2; Belongs to the CTL (choline transporter-like) family. (563 aa)
PGAP4Transmembrane protein 246. (394 aa)
PIP5K1BPIP5K1B isoform 2. (540 aa)
PIGOPIGO isoform 1. (672 aa)
IMPA1-2IMPA1 isoform 7. (241 aa)
DGAT1O-acyltransferase. (487 aa)
GPAA1Glycosylphosphatidylinositol anchor attachment 1. (621 aa)
EFR3AEFR3A isoform 1. (821 aa)
IMPA1Inositol monophosphatase 1; Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4- diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta- glycerophosphate, and 2'-AMP as substrates. (275 aa)
FABP5FABP5 isoform 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
IMPAD1Inositol monophosphatase domain containing 1. (359 aa)
GPAT4Glycerol-3-phosphate acyltransferase 4; Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (By similarity). Active against both saturated and unsaturated long-chain fatty acyl- CoAs (By similarity); Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (456 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (80 aa)
MTMR7Myotubularin-related protein 7; Phosphatase that specifically dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and inositol 1,3- bisphosphate (Ins(1,3)P2); Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. (660 aa)
AGPAT5AGPAT5 isoform 1. (304 aa)
PIK3CGPIK3CG isoform 1; Belongs to the PI3/PI4-kinase family. (1102 aa)
DGKBDiacylglycerol kinase. (780 aa)
AGMOAGMO isoform 1; Belongs to the sterol desaturase family. (442 aa)
DKFZp468N1212FAM126A isoform 6. (419 aa)
ENSPPYP00000019554Putative diacylglycerol O-acyltransferase 2-like protein DGAT2L7P. (119 aa)
MOGAT3MOGAT3 isoform 1. (245 aa)
AGPAT41-acyl-sn-glycerol-3-phosphate acyltransferase delta; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA) (By similarity). (378 aa)
SYNJ2SYNJ2 isoform 1. (1489 aa)
FIG4FIG4 isoform 1. (891 aa)
IP6K3Kinase; Belongs to the inositol phosphokinase (IPK) family. (410 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (287 aa)
SLC44A4SLC44A4 isoform 2; Belongs to the CTL (choline transporter-like) family. (712 aa)
ENSPPYP00000018135Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (503 aa)
LPCAT1Lysophosphatidylcholine acyltransferase 1. (534 aa)
ACSL1ACSL1 isoform 4. (748 aa)
INPP4BType II inositol 3,4-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate (By similarity). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity). (917 aa)
PYURFPIGY upstream reading frame. (113 aa)
CDS1Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (428 aa)
GPAT3Glycerol-3-phosphate acyltransferase 3. (434 aa)
CWH43Cell wall biogenesis 43 C-terminal homolog. (699 aa)
PI4K2BPI4K2B isoform 1. (481 aa)
DGKQDiacylglycerol kinase. (791 aa)
PIGGPIGG isoform 6. (890 aa)
PIGZMannosyltransferase. (333 aa)
PIGXPIGX isoform 1. (392 aa)
PCYT1APhosphate cytidylyltransferase 1, choline, alpha. (367 aa)
DGKGDiacylglycerol kinase. (786 aa)
LIPHLIPH isoform 1. (436 aa)
PLD1Phospholipase. (1074 aa)
PLSCR1Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (318 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). (1357 aa)
ABHD51-acylglycerol-3-phosphate O-acyltransferase ABHD5; Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfert of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl- lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (By similarity). Functions in phosphatidic acid biosynthesis (By similarity). May regulate the cellular storage of [...] (349 aa)
SACM1LPhosphatidylinositide phosphatase SAC1; Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (By similarity). Has low activity towards PtdIns(3,5)P2 (By similarity). (587 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (426 aa)
IP6K1Kinase; Belongs to the inositol phosphokinase (IPK) family. (435 aa)
CISHCytokine inducible SH2 containing protein. (258 aa)
MTMR14MTMR14 isoform 3. (647 aa)
TAMM41TAMM41 isoform 3. (151 aa)
DGKDDiacylglycerol kinase. (1106 aa)
INPP5DINPP5D isoform 3. (1144 aa)
ENSPPYP00000014776annotation not available (183 aa)
PIKFYVEPIKFYVE isoform 1. (2088 aa)
PGAP1GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI- anchored proteins from the endoplasmic reticulum to the Golgi. (1011 aa)
C2orf66Chromosome 2 open reading frame 66. (117 aa)
INPP1INPP1 isoform 1. (399 aa)
SH3YL1SH3 domain-containing YSC84-like protein 1. (342 aa)
LPIN1LPIN1 isoform 1. (925 aa)
SELENOIEthanolaminephosphotransferase 1; Catalyzes phosphatidylethanolamine biosynthesis from CDP- ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via 'Kennedy' pathway (By similarity). (386 aa)
LCLAT1LCLAT1 isoform 3. (394 aa)
MORN2MORN2 isoform 4. (79 aa)
PIGFPhosphatidylinositol glycan anchor biosynthesis class F. (219 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
TTC7ATTC7A isoform 4. (860 aa)
TMEM150ATransmembrane protein 150A. (271 aa)
INPP4AINPP4A isoform 2. (971 aa)
CR201_G0055610GPAT2 isoform 1. (412 aa)
PI4KAPI4KA isoform 1; Belongs to the PI3/PI4-kinase family. (2019 aa)
PLA2G6PLA2G6 isoform 1. (805 aa)
PRR14LProline rich 14 like. (2151 aa)
PISDPhosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. (409 aa)
INPP5JInositol polyphosphate-5-phosphatase J. (1007 aa)
MTMR3Myotubularin related protein 3. (1198 aa)
AGPAT31-acyl-sn-glycerol-3-phosphate acyltransferase gamma; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor (By similarity). Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA. Has a preference for arachidon [...] (376 aa)
PIGPPhosphatidylinositol N-acetylglucosaminyltransferase subunit P; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. (134 aa)
SYNJ1SYNJ1 isoform 6. (1396 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate. (622 aa)
DPM1Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins. (260 aa)
PIGTPhosphatidylinositol glycan anchor biosynthesis, class T. (578 aa)
LPIN3LPIN3 isoform 1. (847 aa)
SLA2Src like adaptor 2. (261 aa)
PIGUPhosphatidylinositol glycan anchor biosynthesis class U. (435 aa)
CDS2Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (401 aa)
CRLS1CRLS1 isoform 1. (301 aa)
GNPATDihydroxyacetone phosphate acyltransferase. (679 aa)
MBOAT7MBOAT7 isoform 2; Belongs to the membrane-bound acyltransferase family. (471 aa)
PLA2G4CPhospholipase A2 group IVC. (542 aa)
ITPKCKinase; Belongs to the inositol phosphokinase (IPK) family. (777 aa)
CR201_G0037390PIK3R2 isoform 1. (641 aa)
SLC27A1SLC27A1 isoform 2. (645 aa)
ABHD8ABHD8 isoform 2. (440 aa)
SLC44A2Choline transporter-like protein 2; Choline transporter; Belongs to the CTL (choline transporter-like) family. (703 aa)
CR201_G0044279PIP5K1C isoform 1. (576 aa)
SOCS6Suppressor of cytokine signaling 6; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5- SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine- phosphorylated receptor (By similarity). (535 aa)
PIGNPhosphatidylinositol glycan anchor biosynthesis class N. (870 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
ABHD3ABHD3 isoform 1. (404 aa)
LPIN2LPIN2 isoform 1. (933 aa)
MPPE1Metallophosphoesterase 1; Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI- anchor proteins (By similarity); Belongs to the metallophosphoesterase superfamily. MPPE1 family. (396 aa)
CR201_G0051275Inositol-1-monophosphatase. (145 aa)
PCYT2PCYT2 isoform 1. (378 aa)
PGS1CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin. (556 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
PGAP3Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family. (320 aa)
BECN1Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] (452 aa)
DGKEDiacylglycerol kinase. (366 aa)
PIGSPIGS isoform 2. (550 aa)
DHRS7BDehydrogenase/reductase SDR family member 7B; Putative oxidoreductase. (271 aa)
PEMTPhosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. (236 aa)
PIGLPhosphatidylinositol glycan anchor biosynthesis class L. (252 aa)
PIK3R6PIK3R6 isoform 2. (696 aa)
PLSCR3Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (295 aa)
PITPNM3PITPNM3 isoform 1. (968 aa)
ALOX15Arachidonate 15-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12- HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the o [...] (662 aa)
INPP5KINPP5K isoform 1. (446 aa)
CR201_G0047047SMG1 isoform 2. (163 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1230 aa)
VAC14VAC14 component of PIKFYVE complex. (782 aa)
PLA2G15PLA2G15 isoform 3. (413 aa)
LCATPhosphatidylcholine-sterol acyltransferase. (360 aa)
LPCAT2LPCAT2 isoform 1. (461 aa)
CDIPTCDP-diacylglycerol--inositol 3-phosphatidyltransferase. (213 aa)
CLN3Battenin. (438 aa)
SMG1SMG1 isoform 8; Belongs to the PI3/PI4-kinase family. (2434 aa)
SOCS1Suppressor of cytokine signaling 1. (213 aa)
PIGQPIGQ isoform 13. (581 aa)
PIGBMannosyltransferase. (555 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (451 aa)
LPCAT4LPCAT4 isoform 1. (495 aa)
TTC7BTTC7B isoform 2. (860 aa)
PIGHPhosphatidylinositol glycan anchor biosynthesis class H. (188 aa)
ATG14Autophagy related 14. (492 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
AJUBALIM domain-containing protein ajuba isoform X1. (538 aa)
ABHD4ABHD4 isoform 1. (251 aa)
DGKHDiacylglycerol kinase. (1241 aa)
MTMR6Myotubularin related protein 6. (621 aa)
PITPNM2Phosphatidylinositol transfer protein membrane associated 2. (1346 aa)
CHPT1CHPT1 isoform 3; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (353 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma; May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum. (421 aa)
ENSPPYP00000005310annotation not available (135 aa)
DGKADiacylglycerol kinase. (786 aa)
ETNK1Ethanolamine kinase 1. (452 aa)
LPCAT3LPCAT3 isoform 2; Belongs to the membrane-bound acyltransferase family. (487 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity). (219 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3003 aa)
MTMR2Myotubularin-related protein 2; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3- phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity). Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5- phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Stabilizes SBF2/MTMR13 at the membranes. Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein (By similarity). (640 aa)
UVRAGUV radiation resistance associated. (699 aa)
DGAT2DGAT2 isoform 2. (445 aa)
MOGAT2Monoacylglycerol O-acyltransferase 2. (334 aa)
INPPL1INPPL1 isoform 2. (1249 aa)
PGAP2Post-GPI attachment to proteins 2. (315 aa)
PIK3C2APhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion dow [...] (1684 aa)
CR201_G0010942Diacylglycerol kinase. (919 aa)
PTPMT1Protein tyrosine phosphatase mitochondrial 1. (201 aa)
CHKACHKA isoform 2. (399 aa)
PNPLA2PNPLA2 isoform 1. (446 aa)
PTDSS2Phosphatidylserine synthase 2. (487 aa)
INPP5FINPP5F isoform 1. (1037 aa)
ENSPPYP00000003091annotation not available (593 aa)
PI4K2APhosphatidylinositol 4-kinase type 2 alpha. (479 aa)
PLCE1Phosphoinositide phospholipase C. (2303 aa)
PTENPongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
IPMKInositol polyphosphate multikinase isoform X2. (416 aa)
CHATCHAT isoform 7; Belongs to the carnitine/choline acetyltransferase family. (637 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (347 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1027 aa)
PIGVGPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. (493 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (530 aa)
PIK3R3T0148502 isoform 1. (461 aa)
SLC44A5SLC44A5 isoform 1; Belongs to the CTL (choline transporter-like) family. (717 aa)
PIGKGPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity). (475 aa)
SLC44A3SLC44A3 isoform 1; Belongs to the CTL (choline transporter-like) family. (629 aa)
FAM102BFAM102B isoform 2. (358 aa)
CEPT1Choline/ethanolamine phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (416 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (549 aa)
PI4KBPhosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (828 aa)
DPM3Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the ER. Belongs to the DPM3 family. (92 aa)
PIGMGPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN- acyl-PI during GPI precursor assembly (By similarity). (423 aa)
PIGCPhosphatidylinositol glycan anchor biosynthesis class C. (297 aa)
CR201_G0021695RGSL1 isoform 2. (365 aa)
RGSL1RGSL1 isoform 10. (536 aa)
PLA2G4ACytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response (By similarity). (749 aa)
ETNK2ETNK2 isoform 7. (252 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
LPGAT1Lysophosphatidylglycerol acyltransferase 1. (370 aa)
BPNT1BPNT1 isoform 1. (324 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (946 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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