STRINGSTRING
ANXA3 ANXA3 KIT KIT CLNK CLNK NLGN1 NLGN1 ERC2 ERC2 CADPS CADPS ARL8B ARL8B ABCA12 ABCA12 RAPGEF4 RAPGEF4 CR201_G0000874 CR201_G0000874 RAP1B RAP1B KLRF2 KLRF2 CBL CBL TPH1 TPH1 MRGPRX2 MRGPRX2 STX3 STX3 SYT7 SYT7 SYT12 SYT12 SYT8 SYT8 CR201_G0054731 CR201_G0054731 CTBP2 CTBP2 RAB11FIP2 RAB11FIP2 PPP3CB PPP3CB SDF4 SDF4 VAMP3 VAMP3 PIK3CD PIK3CD RIMS3 RIMS3 STXBP3 STXBP3 RAP1A RAP1A SYT6 SYT6 SV2A SV2A S100A13 S100A13 SNAPIN SNAPIN SYT11 SYT11 TMEM79 TMEM79 SYT2 SYT2 SNAP47 SNAP47 ZP4 ZP4 DNM1P50 DNM1P50 SYNGR4 SYNGR4 RAB3A RAB3A UNC13A UNC13A RAB11B RAB11B STXBP2 STXBP2 CR201_G0044279 CR201_G0044279 RAB10 RAB10 CPLX4 CPLX4 PPFIA3 PPFIA3 SYT3 SYT3 NKG7 NKG7 SYT5 SYT5 NLRP5 NLRP5 ENSPPYP00000011868 ENSPPYP00000011868 SNAP25 SNAP25 SNPH SNPH HCK HCK DNAJC5 DNAJC5 SYT9 SYT9 CPLX3 CPLX3 VAMP7 VAMP7 BTK BTK CLTRN CLTRN ENSPPYP00000022364 ENSPPYP00000022364 SYNJ1 SYNJ1 SEPT5 SEPT5 ENSPPYP00000012962 ENSPPYP00000012962 BCR BCR PLA2G3 PLA2G3 MYH9 MYH9 SYNGR1 SYNGR1 RAB11FIP5 RAB11FIP5 PLEK PLEK OTOF OTOF NOTCH1 NOTCH1 ENSPPYP00000022196 ENSPPYP00000022196 NR4A3 NR4A3 GRP GRP SYT4 SYT4 RAB31 RAB31 SYNGR2 SYNGR2 UNC13D UNC13D MILR1 MILR1 ADORA2B ADORA2B P2RX1 P2RX1 ENSPPYP00000008720 ENSPPYP00000008720 STX4 STX4 STX1B STX1B PRRT2 PRRT2 DOC2A DOC2A CORO1A CORO1A LAT LAT ARHGAP17 ARHGAP17 RAB26 RAB26 SYNGR3 SYNGR3 RAB27A RAB27A UNC13C UNC13C ENSPPYP00000007360 ENSPPYP00000007360 CR201_G0046277 CR201_G0046277 SNAP23 SNAP23 RASGRP1 RASGRP1 CHGA CHGA PSEN1 PSEN1 PTGDR PTGDR ABCC4 ABCC4 STX2 STX2 P2RX7 P2RX7 SYK SYK EQTN EQTN UNC13B UNC13B SCRIB SCRIB RIMS2 RIMS2 LYN LYN RAB11FIP1 RAB11FIP1 DMTN DMTN BLK BLK CDK5 CDK5 BRAF BRAF CADPS2 CADPS2 PIK3CG PIK3CG STEAP2 STEAP2 SCIN SCIN RABGEF1 RABGEF1 STX1A STX1A LAT2 LAT2 STX11 STX11 RIMS1 RIMS1 ENSPPYP00000018739 ENSPPYP00000018739 LRRC1 LRRC1 CPLX2 CPLX2 CRHBP CRHBP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANXA3Annexin. (323 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (770 aa)
CLNKCLNK isoform 1. (412 aa)
NLGN1NLGN1 isoform 2. (823 aa)
ERC2ERC2 isoform 1. (914 aa)
CADPSCADPS isoform 2. (1380 aa)
ARL8BADP-ribosylation factor-like protein 8B; Plays a role in lysosome motility. In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (By similarity). (185 aa)
ABCA12ABCA12 isoform 1. (2510 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
CR201_G0000874P2RX7 isoform 7. (101 aa)
RAP1BRas-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa)
KLRF2KLRF2 isoform 1. (47 aa)
CBLCbl proto-oncogene. (905 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
MRGPRX2MAS related GPR family member X2; Belongs to the G-protein coupled receptor 1 family. (330 aa)
STX3STX3 isoform 3; Belongs to the syntaxin family. (289 aa)
SYT7SYT7 isoform 1. (400 aa)
SYT12SYT12 isoform 1. (421 aa)
SYT8SYT8 isoform 4. (397 aa)
CR201_G0054731T0193459 isoform 3. (473 aa)
CTBP2CTBP2 isoform 10. (985 aa)
RAB11FIP2RAB11 family interacting protein 2. (512 aa)
PPP3CBSerine/threonine-protein phosphatase. (438 aa)
SDF4SDF4 isoform 1. (336 aa)
VAMP3Vesicle associated membrane protein 3. (100 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1027 aa)
RIMS3RIMS3 isoform 1. (285 aa)
STXBP3STXBP3 isoform 1; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
SYT6SYT6 isoform 1. (509 aa)
SV2ASynaptic vesicle glycoprotein 2A; Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). (637 aa)
S100A13S100 calcium binding protein A13; Belongs to the S-100 family. (98 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
SYT11SYT11 isoform 1. (388 aa)
TMEM79TMEM79 isoform 2. (394 aa)
SYT2SYT2 isoform 1. (359 aa)
SNAP47SNAP47 isoform 1. (459 aa)
ZP4ZP4 isoform 1. (540 aa)
DNM1P50Dynamin-1. (67 aa)
SYNGR4Synaptogyrin. (234 aa)
RAB3ARas-related protein Rab-3A. (203 aa)
UNC13AUNC13A isoform 4. (1518 aa)
RAB11BRAB11B, member RAS oncogene family. (218 aa)
STXBP2Syntaxin binding protein 2. (592 aa)
CR201_G0044279PIP5K1C isoform 1. (576 aa)
RAB10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (By similarity). Regulates, for instance, SLC [...] (199 aa)
CPLX4CPLX4 isoform 2. (160 aa)
PPFIA3PPFIA3 isoform 1. (1047 aa)
SYT3Synaptotagmin 3. (590 aa)
NKG7Natural killer cell granule protein 7. (165 aa)
SYT5SYT5 isoform 2. (386 aa)
NLRP5NLRP5 isoform 3. (1197 aa)
ENSPPYP00000011868annotation not available (149 aa)
SNAP25Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. (206 aa)
SNPHSNPH isoform 2. (535 aa)
HCKTyrosine-protein kinase. (449 aa)
DNAJC5DnaJ heat shock protein family (Hsp40) member C5. (198 aa)
SYT9SYT9 isoform 2. (173 aa)
CPLX3CPLX3 isoform 1. (158 aa)
VAMP7Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] (220 aa)
BTKTyrosine-protein kinase. (659 aa)
CLTRNTMEM27 isoform 1. (247 aa)
ENSPPYP00000022364annotation not available (138 aa)
SYNJ1SYNJ1 isoform 6. (1396 aa)
SEPT5SEPT5 isoform 6; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (256 aa)
ENSPPYP00000012962annotation not available (96 aa)
BCRBCR isoform 1. (1271 aa)
PLA2G3PLA2G3 isoform 1. (505 aa)
MYH9MYH9 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1959 aa)
SYNGR1Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity (By similarity). Belongs to the synaptogyrin family. (654 aa)
RAB11FIP5RAB11FIP5 isoform 2. (589 aa)
PLEKPLEK isoform 1. (350 aa)
OTOFOTOF isoform 2. (1545 aa)
NOTCH1NOTCH1 isoform 1. (2107 aa)
ENSPPYP00000022196annotation not available (199 aa)
NR4A3NR4A3 isoform 1. (626 aa)
GRPGastrin releasing peptide. (142 aa)
SYT4SYT4 isoform 1. (425 aa)
RAB31RAB31, member RAS oncogene family. (195 aa)
SYNGR2Synaptogyrin. (245 aa)
UNC13DUNC13D isoform 1. (1042 aa)
MILR1MILR1 isoform 1. (210 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (355 aa)
ENSPPYP00000008720annotation not available (160 aa)
STX4STX4 isoform 4; Belongs to the syntaxin family. (296 aa)
STX1BSTX1B isoform 1; Belongs to the syntaxin family. (590 aa)
PRRT2Proline-rich transmembrane protein 2; As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation. (340 aa)
DOC2ADouble C2-like domain-containing protein. (398 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (445 aa)
LATLAT isoform 2. (233 aa)
ARHGAP17ARHGAP17 isoform 10. (834 aa)
RAB26RAB26 isoform 1. (290 aa)
SYNGR3Synaptogyrin. (196 aa)
RAB27ARAB27A, member RAS oncogene family. (221 aa)
UNC13CUNC13C isoform 1. (1180 aa)
ENSPPYP00000007360annotation not available (418 aa)
CR201_G0046277Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (143 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
RASGRP1RASGRP1 isoform 2. (787 aa)
CHGACHGA isoform 1. (457 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (463 aa)
PTGDRProstaglandin D2 receptor. (359 aa)
ABCC4ABCC4 isoform 3. (1264 aa)
STX2STX2 isoform 2; Belongs to the syntaxin family. (263 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
SYKTyrosine-protein kinase. (588 aa)
EQTNEQTN isoform 1. (294 aa)
UNC13BUNC13B isoform 5. (1610 aa)
SCRIBSCRIB isoform 2. (1472 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1163 aa)
LYNTyrosine-protein kinase. (512 aa)
RAB11FIP1RAB11 family interacting protein 1. (1275 aa)
DMTNDematin; Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator [...] (405 aa)
BLKTyrosine-protein kinase. (505 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
BRAFBRAF isoform 1. (765 aa)
CADPS2CADPS2 isoform 1. (1197 aa)
PIK3CGPIK3CG isoform 1; Belongs to the PI3/PI4-kinase family. (1102 aa)
STEAP2STEAP2 isoform 3. (479 aa)
SCINSCIN isoform 3. (715 aa)
RABGEF1RABGEF1 isoform 2. (544 aa)
STX1ASyntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...] (259 aa)
LAT2Linker for activation of T cells family member 2. (244 aa)
STX11STX11 isoform 1; Belongs to the syntaxin family. (287 aa)
RIMS1RIMS1 isoform 16. (1644 aa)
ENSPPYP00000018739annotation not available (186 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
CPLX2CPLX2 isoform 1. (134 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (282 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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