STRINGSTRING
MYT1L MYT1L GLI2 GLI2 ACVR1 ACVR1 TBR1 TBR1 DLX1 DLX1 DLX2 DLX2 CR201_G0017164 CR201_G0017164 HOXD10 HOXD10 ERBB4 ERBB4 WNT6 WNT6 WNT10A WNT10A FEV FEV IHH IHH KDR KDR WT1 WT1 DLL4 DLL4 CR201_G0026379 CR201_G0026379 CR201_G0011157 CR201_G0011157 APC APC IFRD1 IFRD1 IL6R IL6R BMP2 BMP2 NEUROD1 NEUROD1 KDM6B KDM6B FGF13 FGF13 TBX22 TBX22 FOXP3 FOXP3 GATA1 GATA1 CR201_G0013169 CR201_G0013169 NOTCH1 NOTCH1 LHX3 LHX3 KLF4 KLF4 TGFBR1 TGFBR1 PTCH1 PTCH1 CTSL CTSL GAS1 GAS1 DMRT3 DMRT3 EXT1 EXT1 IL7 IL7 EYA1 EYA1 PRDM14 PRDM14 TOX TOX SOX17 SOX17 PRKDC PRKDC NKX6-3 NKX6-3 CR201_G0033322 CR201_G0033322 NRG1 NRG1 EBF2 EBF2 GATA4 GATA4 MNX1 MNX1 SHH SHH GBX1 GBX1 BRAF BRAF KIAA1549 KIAA1549 SMO SMO WNT16 WNT16 SOSTDC1 SOSTDC1 IL6 IL6 HOXA2 HOXA2 HOXA11 HOXA11 HOXA13 HOXA13 TBX20 TBX20 GLI3 GLI3 MYL10 MYL10 DLL1 DLL1 TBXT TBXT LATS1 LATS1 OLIG3 OLIG3 HEY2 HEY2 NR2E1 NR2E1 PRDM1 PRDM1 TBX18 TBX18 ENSPPYP00000018739 ENSPPYP00000018739 GCM1 GCM1 RUNX2 RUNX2 SPDEF SPDEF NOTCH4 NOTCH4 EHMT2 EHMT2 EDN1 EDN1 IRF4 IRF4 CR201_G0004819 CR201_G0004819 TLX3 TLX3 WNT8A WNT8A SMAD5 SMAD5 NEUROG1 NEUROG1 PITX1 PITX1 MEF2C MEF2C ISL1 ISL1 FGF10 FGF10 ATOH1 ATOH1 CASP3 CASP3 SFRP2 SFRP2 EDNRA EDNRA SMAD1 SMAD1 ENSPPYP00000016868 ENSPPYP00000016868 GSX2 GSX2 HES1 HES1 VWA5B2 VWA5B2 ENSPPYP00000016046 ENSPPYP00000016046 SOX2 SOX2 EOMES EOMES CTNNB1 CTNNB1 RHOA RHOA WNT5A WNT5A FEZF2 FEZF2 MITF MITF PPARG PPARG GATA2 GATA2 ENSPPYP00000014984 ENSPPYP00000014984 WNT3A WNT3A WNT9A WNT9A PROX1 PROX1 SOX13 SOX13 MYOG MYOG CDC73 CDC73 PRRX1 PRRX1 TBX19 TBX19 SLAMF6 SLAMF6 SLAMF8 SLAMF8 ARHGEF2 ARHGEF2 MCL1 MCL1 TBX15 TBX15 WNT2B WNT2B BARHL2 BARHL2 DOCK7 DOCK7 DMRTA2 DMRTA2 TAL1 TAL1 PTCH2 PTCH2 WNT4 WNT4 CDC42 CDC42 PDPN PDPN GATA3 GATA3 PTF1A PTF1A NRP1 NRP1 NODAL NODAL WNT8B WNT8B PAX2 PAX2 LBX1 LBX1 CR201_G0023542 CR201_G0023542 SUFU SUFU CR201_G0012836 CR201_G0012836 FGFR2 FGFR2 NKX6-2 NKX6-2 TBX10 TBX10 ENSPPYP00000003457 ENSPPYP00000003457 RAG2 RAG2 PAX6 PAX6 DBX1 DBX1 MYOD1 MYOD1 CTR9 CTR9 WNT11 WNT11 TENM4 TENM4 DSCAML1 DSCAML1 VWA5A VWA5A CDON CDON NTF3 NTF3 SOX5 SOX5 WNT10B WNT10B WNT1 WNT1 DHH DHH HOXC10 HOXC10 NEUROD4 NEUROD4 STAT6 STAT6 MYF6 MYF6 MYF5 MYF5 ASCL1 ASCL1 FOXN4 FOXN4 MYL2 MYL2 TBX5 TBX5 TBX3 TBX3 LATS2 LATS2 GSX1 GSX1 ENSPPYP00000006185 ENSPPYP00000006185 SOX1 SOX1 FOXG1 FOXG1 NKX2-1 NKX2-1 FOXA1 FOXA1 BMP4 BMP4 PSEN1 PSEN1 BATF BATF GSC GSC BCL11B BCL11B ENSPPYP00000007046 ENSPPYP00000007046 RTF1 RTF1 MGA MGA LEO1 LEO1 ONECUT1 ONECUT1 PML PML ISL2 ISL2 NR2F2 NR2F2 TM2D3 TM2D3 MESP1 MESP1 SOX8 SOX8 TBX6 TBX6 SPN SPN ZFPM1 ZFPM1 TGFB1I1 TGFB1I1 TP53 TP53 FOXN1 FOXN1 WNT9B WNT9B WNT3 WNT3 STAT3 STAT3 RARA RARA SOX9 SOX9 TBX2 TBX2 TBX4 TBX4 TBX21 TBX21 GATA6 GATA6 ZNF521 ZNF521 SMAD2 SMAD2 SMAD4 SMAD4 ONECUT2 ONECUT2 BCL2 BCL2 APC2 APC2 TCF3 TCF3 NOTCH3 NOTCH3 FKBP8 FKBP8 ETV2 ETV2 PAF1 PAF1 ENSPPYP00000011451 ENSPPYP00000011451 NTF4 NTF4 VWA5B1 VWA5B1 JAG1 JAG1 NKX2-2 NKX2-2 CR201_G0019832 CR201_G0019832 SOX12 SOX12 EYA2 EYA2 GATA5 GATA5 OLIG2 OLIG2 ETS2 ETS2 TBX1 TBX1 WNT7B WNT7B PRADC1 PRADC1 CYP26B1 CYP26B1 EPAS1 EPAS1 SIX2 SIX2 RAB10 RAB10 GDF7 GDF7 ID2 ID2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYT1LMYT1L isoform 3. (1184 aa)
GLI2GLI2 isoform 1. (1521 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
TBR1T-box brain transcription factor 1. (682 aa)
DLX1Distal-less homeobox 1. (255 aa)
DLX2Distal-less homeobox 2. (328 aa)
CR201_G0017164HOXD11 isoform 2. (143 aa)
HOXD10HOXD10 isoform 3. (340 aa)
ERBB4Receptor protein-tyrosine kinase. (1284 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (422 aa)
FEVFEV isoform 1. (239 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
WT1WT1 isoform 2. (320 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
CR201_G0026379POU domain protein. (458 aa)
CR201_G0011157PAX6 isoform 63. (257 aa)
APCAdenomatous polyposis coli protein isoform X2. (2861 aa)
IFRD1IFRD1 isoform 4. (405 aa)
IL6RIL6R isoform 2. (499 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
KDM6BKDM6B isoform 2. (942 aa)
FGF13Fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). May regulate voltage-gated sodium channels transport and function (By similarity). May also play a role in MAPK signaling (By similarity). [...] (245 aa)
TBX22T-box transcription factor 22. (520 aa)
FOXP3FOXP3 isoform 1. (431 aa)
GATA1GATA1 isoform 1. (290 aa)
CR201_G0013169ARX isoform 4. (297 aa)
NOTCH1NOTCH1 isoform 1. (2107 aa)
LHX3LHX3 isoform 2. (402 aa)
KLF4Kruppel like factor 4. (479 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
PTCH1PTCH1 isoform 7. (1429 aa)
CTSLCTSL isoform 2; Belongs to the peptidase C1 family. (333 aa)
GAS1Growth arrest specific 1. (347 aa)
DMRT3DMRT3 isoform 1. (131 aa)
EXT1Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). (746 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (177 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
PRDM14PRDM14 isoform 1. (571 aa)
TOXThymocyte selection associated high mobility group box. (526 aa)
SOX17SRY-box transcription factor 17. (416 aa)
PRKDCPRKDC isoform 1; Belongs to the PI3/PI4-kinase family. (3972 aa)
NKX6-3NKX6-3 isoform 1. (136 aa)
CR201_G0033322SFRP1 isoform 1. (260 aa)
NRG1NRG1 isoform 10. (692 aa)
EBF2EBF transcription factor 2. (575 aa)
GATA4GATA binding protein 4. (442 aa)
MNX1MNX1 isoform 4. (363 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (460 aa)
GBX1GBX1 isoform 1. (203 aa)
BRAFBRAF isoform 1. (765 aa)
KIAA1549KIAA1549 isoform 1. (1901 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SOSTDC1Sclerostin domain-containing protein 1; Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. Enhances Wnt signaling and inhibits TGF-beta signaling. May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction (By similarity). (206 aa)
IL6IL6 isoform 2. (212 aa)
HOXA2HOXA2 isoform 1. (374 aa)
HOXA11HOXA11 isoform 2. (315 aa)
HOXA13HOXA13 isoform 1. (316 aa)
TBX20TBX20 isoform 1. (447 aa)
GLI3GLI3 isoform 3. (1580 aa)
MYL10Myosin light chain 10. (226 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
TBXTT-box transcription factor T. (435 aa)
LATS1Large tumor suppressor kinase 1. (1130 aa)
OLIG3Oligodendrocyte transcription factor 3. (272 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
PRDM1PR/SET domain 1. (825 aa)
TBX18T-box transcription factor 18. (607 aa)
ENSPPYP00000018739annotation not available (186 aa)
GCM1Glial cells missing transcription factor 1. (436 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (589 aa)
SPDEFSPDEF isoform 2. (316 aa)
NOTCH4NOTCH4 isoform 1. (2000 aa)
EHMT2EHMT2 isoform 5. (1267 aa)
EDN1EDN1 isoform 1. (212 aa)
IRF4IRF4 isoform 1. (441 aa)
CR201_G0004819NKX2-5 isoform 1. (210 aa)
TLX3TLX3 isoform 1. (338 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
SMAD5Mothers against decapentaplegic homolog 5; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor- regulated SMAD (R-SMAD) (By similarity). (465 aa)
NEUROG1NEUROG1 isoform 1. (237 aa)
PITX1Homeobox protein. (313 aa)
MEF2CMyocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (441 aa)
ISL1ISL1 isoform 1. (349 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ATOH1Atonal bHLH transcription factor 1. (354 aa)
CASP3CASP3 isoform 1; Belongs to the peptidase C14A family. (277 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
EDNRAEDNRA isoform 1; Belongs to the G-protein coupled receptor 1 family. (425 aa)
SMAD1Mothers against decapentaplegic homolog. (73 aa)
ENSPPYP00000016868annotation not available (85 aa)
GSX2GSX2 isoform 2. (305 aa)
HES1HES1 isoform 1. (198 aa)
VWA5B2VWA5B2 isoform 1. (1000 aa)
ENSPPYP00000016046annotation not available (124 aa)
SOX2SRY-box transcription factor 2. (319 aa)
EOMESEOMES isoform 3. (704 aa)
CTNNB1CTNNB1 isoform 2. (781 aa)
RHOATransforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (196 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (473 aa)
FEZF2FEZ family zinc finger 2. (460 aa)
MITFMelanocyte inducing transcription factor. (520 aa)
PPARGPeroxisome proliferator-activated receptor gamma. (477 aa)
GATA2GATA2 isoform 1. (408 aa)
ENSPPYP00000014984annotation not available (349 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (385 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (318 aa)
PROX1Prospero homeobox 1. (737 aa)
SOX13SRY-box transcription factor 13. (623 aa)
MYOGMYOG isoform 1. (224 aa)
CDC73Cell division cycle 73. (531 aa)
PRRX1PRRX1 isoform 3. (216 aa)
TBX19TBX19 isoform 1. (427 aa)
SLAMF6SLAM family member 6. (332 aa)
SLAMF8SLAMF8 isoform 1. (270 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (986 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
TBX15T-box transcription factor 15. (496 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
BARHL2BarH like homeobox 2. (387 aa)
DOCK7DOCK7 isoform 6; Belongs to the DOCK family. (2108 aa)
DMRTA2DMRTA2 isoform 1. (465 aa)
TAL1TAL1 isoform 1. (194 aa)
PTCH2PTCH2 isoform 1. (1203 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
CDC42Cell division cycle 42. (191 aa)
PDPNPDPN isoform 1. (236 aa)
GATA3GATA binding protein 3. (444 aa)
PTF1APTF1A isoform 1. (422 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
NODALNodal growth differentiation factor. (347 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
PAX2PAX2 isoform 3. (388 aa)
LBX1Ladybird homeobox 1. (281 aa)
CR201_G0023542Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (166 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
CR201_G0012836TCF7L2 isoform 2. (430 aa)
FGFR2Fibroblast growth factor receptor. (656 aa)
NKX6-2NKX6-2 isoform 2. (277 aa)
TBX10TBX10 isoform 1. (180 aa)
ENSPPYP00000003457annotation not available (127 aa)
RAG2Recombination activating 2. (527 aa)
PAX6PAX6 isoform 13. (266 aa)
DBX1Developing brain homeobox 1. (381 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
CTR9CTR9 isoform 1. (1173 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
TENM4TENM4 isoform 2. (2794 aa)
DSCAML1DSCAML1 isoform 2. (2118 aa)
VWA5AVWA5A isoform 1. (821 aa)
CDONCDON isoform 2. (1112 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (257 aa)
SOX5SOX5 isoform 3. (715 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (317 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
HOXC10Homeobox protein Hox-C10. (342 aa)
NEUROD4Neurogenic differentiation factor. (331 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
MYF6Myogenic factor 6. (242 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (235 aa)
FOXN4FOXN4 isoform 1. (517 aa)
MYL2MYL2 isoform 2. (146 aa)
TBX5T-box transcription factor 5. (518 aa)
TBX3T-box transcription factor 3. (743 aa)
LATS2Non-specific serine/threonine protein kinase. (1098 aa)
GSX1GSX1 isoform 1. (264 aa)
ENSPPYP00000006185annotation not available (303 aa)
SOX1SOX1 isoform 1. (372 aa)
FOXG1FOXG1 isoform 8. (440 aa)
NKX2-1NKX2-1 isoform 1. (401 aa)
FOXA1FOXA1 isoform 1. (448 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (463 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
GSCGoosecoid homeobox. (257 aa)
BCL11BBCL11B isoform 1. (893 aa)
ENSPPYP00000007046annotation not available (868 aa)
RTF1RNA polymerase-associated protein RTF1 homolog; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription [...] (710 aa)
MGAMGA isoform 3. (3030 aa)
LEO1RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox [...] (666 aa)
ONECUT1One cut domain family member. (465 aa)
PMLPML isoform 4. (869 aa)
ISL2ISL LIM homeobox 2. (359 aa)
NR2F2NR2F2 isoform 3. (377 aa)
TM2D3TM2D3 isoform 8. (192 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (269 aa)
SOX8SRY-box transcription factor 8. (446 aa)
TBX6TBX6 isoform 2. (436 aa)
SPNSPN isoform 1. (400 aa)
ZFPM1ZFPM1 isoform 1. (344 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (461 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
FOXN1FOXN1 isoform 2. (648 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
STAT3Signal transducer and activator of transcription. (772 aa)
RARARARA isoform 2. (460 aa)
SOX9SRY-box transcription factor 9. (509 aa)
TBX2TBX2 isoform 1. (588 aa)
TBX4T-box transcription factor 4. (544 aa)
TBX21T-box transcription factor 21. (535 aa)
GATA6GATA6 isoform 1. (580 aa)
ZNF521ZNF521 isoform 3. (1311 aa)
SMAD2Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] (467 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ONECUT2One cut domain family member. (472 aa)
BCL2BCL2 isoform 1. (238 aa)
APC2APC2 isoform 1. (2148 aa)
TCF3TCF3 isoform 5. (603 aa)
NOTCH3NOTCH3 isoform 1. (2321 aa)
FKBP8Peptidylprolyl isomerase. (413 aa)
ETV2ETV2 isoform 4. (370 aa)
PAF1RNA polymerase II-associated factor 1 homolog; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription [...] (533 aa)
ENSPPYP00000011451annotation not available (257 aa)
NTF4Neurotrophin 4. (210 aa)
VWA5B1VWA5B1 isoform 1. (343 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
NKX2-2NKX2-2 isoform 1. (273 aa)
CR201_G0019832T0068022 isoform 1. (302 aa)
SOX12Transcription factor SOX. (314 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (529 aa)
GATA5GATA binding protein 5. (397 aa)
OLIG2Oligodendrocyte transcription factor 2. (323 aa)
ETS2Protein C-ets-2; Transcription factor; Belongs to the ETS family. (469 aa)
TBX1TBX1 isoform 2. (213 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
PRADC1PRADC1 isoform 3. (244 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
EPAS1Endothelial PAS domain protein 1. (869 aa)
SIX2SIX homeobox 2. (291 aa)
RAB10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (By similarity). Regulates, for instance, SLC [...] (199 aa)
GDF7GDF7 isoform 1. (447 aa)
ID2DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] (134 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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