STRINGSTRING
ZFPM2 ZFPM2 WISP1 WISP1 CR201_G0053199 CR201_G0053199 SIRT2 SIRT2 ID4 ID4 FLCN FLCN MMP11 MMP11 CR201_G0055029 CR201_G0055029 ZFP36L2 ZFP36L2 TRIB2 TRIB2 ENSPPYP00000014180 ENSPPYP00000014180 CR201_G0045384 CR201_G0045384 GATA2 GATA2 WNT5A WNT5A WNT3A WNT3A SORT1 SORT1 GATA3 GATA3 SIRT1 SIRT1 WWTR1 WWTR1 ADIPOQ ADIPOQ BBS12 BBS12 TRIO TRIO ENPP1 ENPP1 IL6 IL6 CCDC85B CCDC85B ARNTL ARNTL YAP1 YAP1 RUNX1T1 RUNX1T1 WNT10B WNT10B WNT1 WNT1 C1QL4 C1QL4 DDIT3 DDIT3 TRPV4 TRPV4 FOXO1 FOXO1 FERMT2 FERMT2 JDP2 JDP2 RORA RORA SMAD3 SMAD3 CR201_G0054585 CR201_G0054585 TLCD3B TLCD3B ZFPM1 ZFPM1 TGFB1I1 TGFB1I1 LOC112129374 LOC112129374 CR201_G0035225 CR201_G0035225 INSIG1 INSIG1 ZADH2 ZADH2 LRP3 LRP3 TGFB1 TGFB1 CR201_G0043144 CR201_G0043144 JAG1 JAG1 TRIB3 TRIB3 ASXL1 ASXL1 E2F1 E2F1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZFPM2ZFPM2 isoform 1. (1152 aa)
WISP1WISP1 isoform 1. (130 aa)
CR201_G0053199POTEB2 isoform 2. (305 aa)
SIRT2NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtu [...] (389 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
FLCNT0179577 isoform 1. (579 aa)
MMP11MMP11 isoform 4. (452 aa)
CR201_G0055029ANK_REP_REGION domain-containing protein. (402 aa)
ZFP36L2ZFP36L2 isoform 1. (338 aa)
TRIB2Tribbles homolog 2; Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily. (343 aa)
ENSPPYP00000014180annotation not available (364 aa)
CR201_G0045384POTEE isoform 2. (576 aa)
GATA2GATA2 isoform 1. (408 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (473 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (385 aa)
SORT1Sortilin. (789 aa)
GATA3GATA binding protein 3. (444 aa)
SIRT1SIRT1 isoform 1. (746 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
BBS12Bardet-Biedl syndrome 12 protein homolog; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation. (485 aa)
TRIOTRIO isoform 3. (3011 aa)
ENPP1ENPP1 isoform 1. (925 aa)
IL6IL6 isoform 2. (212 aa)
CCDC85BCoiled-coil domain containing 85B. (202 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like protein 1; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressur [...] (583 aa)
YAP1YAP1 isoform 2. (326 aa)
RUNX1T1RUNX1 partner transcriptional co-repressor 1. (577 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (317 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
C1QL4C1QL4 isoform 1. (235 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
TRPV4TRPV4 isoform 2; Belongs to the transient receptor (TC 1.A.4) family. (699 aa)
FOXO1FOXO1 isoform 1. (654 aa)
FERMT2FERMT2 isoform 1. (623 aa)
JDP2JDP2 isoform 3. (238 aa)
RORARORA isoform 12. (555 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
CR201_G0054585AXIN1 isoform 6. (551 aa)
TLCD3BFAM57B isoform 5. (274 aa)
ZFPM1ZFPM1 isoform 1. (344 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (461 aa)
LOC112129374Putative ankyrin repeat domain-containing protein 26-like protein. (330 aa)
CR201_G0035225CCDC144A isoform 1. (482 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (277 aa)
ZADH2Zinc binding alcohol dehydrogenase domain containing 2. (377 aa)
LRP3LRP3 isoform 1. (769 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
CR201_G0043144ANKRD36 isoform 6. (119 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
TRIB3TRIB3 isoform 1. (358 aa)
ASXL1ASXL transcriptional regulator 1. (1476 aa)
E2F1E2F1 isoform 1. (361 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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