STRINGSTRING
TNFAIP6 TNFAIP6 GREM2 GREM2 TNN TNN ID3 ID3 SKI SKI UCMA UCMA BAMBI BAMBI GDF10 GDF10 SUFU SUFU MEN1 MEN1 HDAC7 HDAC7 FGF23 FGF23 GREM1 GREM1 ENSPPYP00000018739 ENSPPYP00000018739 SMAD6 SMAD6 SMAD3 SMAD3 NOG NOG AXIN2 AXIN2 SOX9 SOX9 TWSG1 TWSG1 CR201_G0029615 CR201_G0029615 CRIM1 CRIM1 PPARG PPARG LIMD1 LIMD1 FNDC3B FNDC3B CHRD CHRD OSTN OSTN AREG AREG NOCT NOCT HAND2 HAND2 VEGFC VEGFC TNF TNF HOXA2 HOXA2 TWIST1 TWIST1 CDK6 CDK6 CR201_G0033322 CR201_G0033322 TMEM64 TMEM64 RORB RORB SEMA4D SEMA4D PTCH1 PTCH1 NOTCH1 NOTCH1 HDAC8 HDAC8 ENSPPYP00000023969 ENSPPYP00000023969
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNFAIP6TNF alpha induced protein 6. (277 aa)
GREM2Gremlin. (168 aa)
TNNTNN isoform 1. (1237 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
SKISKI isoform 1. (406 aa)
UCMAUCMA isoform 1. (105 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
MEN1MEN1 isoform 1. (610 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (918 aa)
FGF23Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (193 aa)
GREM1Gremlin. (184 aa)
ENSPPYP00000018739annotation not available (186 aa)
SMAD6Mothers against decapentaplegic homolog. (404 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
AXIN2AXIN2 isoform 1. (843 aa)
SOX9SRY-box transcription factor 9. (509 aa)
TWSG1Twisted gastrulation protein homolog 1; May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity); Belongs to the twisted gastrulation protei [...] (223 aa)
CR201_G0029615TRPM4 isoform 6. (870 aa)
CRIM1CRIM1 isoform 1. (824 aa)
PPARGPeroxisome proliferator-activated receptor gamma. (477 aa)
LIMD1LIM domains containing 1. (676 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (938 aa)
OSTNOSTN isoform 2. (133 aa)
AREGAREG isoform 1. (252 aa)
NOCTNOCT isoform 2. (431 aa)
HAND2HAND2 isoform 1. (217 aa)
VEGFCVEGFC isoform 1; Belongs to the PDGF/VEGF growth factor family. (418 aa)
TNFTumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family. (233 aa)
HOXA2HOXA2 isoform 1. (374 aa)
TWIST1Twist family bHLH transcription factor 1. (203 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
CR201_G0033322SFRP1 isoform 1. (260 aa)
TMEM64TMEM64 isoform 1. (380 aa)
RORBRORB isoform 1. (516 aa)
SEMA4DSEMA4D isoform 10; Belongs to the semaphorin family. (862 aa)
PTCH1PTCH1 isoform 7. (1429 aa)
NOTCH1NOTCH1 isoform 1. (2107 aa)
HDAC8CITED1 isoform 1. (390 aa)
ENSPPYP00000023969annotation not available (161 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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