Your Input: | |
| | DTL | DTL isoform 2. (659 aa) |
| | C4BPA | C4BPA isoform 1. (614 aa) |
| | C4BPB | Complement component 4 binding protein beta. (252 aa) |
| | COP1 | COP1 E3 ubiquitin ligase. (731 aa) |
| | OAZ3 | OAZ3 isoform 3. (189 aa) |
| | SEC22B | Vesicle-trafficking protein SEC22b; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. (215 aa) |
| | PCSK9 | PCSK9 isoform 1. (809 aa) |
| | ZYG11A | Zyg-11 family member A, cell cycle regulator. (759 aa) |
| | ZYG11B | Zyg-11 family member B, cell cycle regulator. (744 aa) |
| | CR201_G0041907 | Serine/threonine-protein kinase PLK. (286 aa) |
| | CDC20 | Cell division cycle 20. (499 aa) |
| | RNF19B | RBR-type E3 ubiquitin transferase. (629 aa) |
| | TNFRSF1B | TNFRSF1B isoform 2. (455 aa) |
| | DVL1 | DVL1 isoform 2. (594 aa) |
| | CR201_G0044109 | RACK1 isoform 5. (346 aa) |
| | IDE | Insulin degrading enzyme; Belongs to the peptidase M16 family. (1019 aa) |
| | CR201_G0036491 | ADAM8 isoform 1. (765 aa) |
| | ENSPPYP00000003414 | annotation not available (440 aa) |
| | STX5 | STX5 isoform 1; Belongs to the syntaxin family. (355 aa) |
| | DDB1 | DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiqui [...] (1135 aa) |
| | PSMC3 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa) |
| | PACSIN3 | Protein kinase C and casein kinase substrate in neurons 3. (424 aa) |
| | RDX | RDX isoform 3. (604 aa) |
| | VPS11 | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (941 aa) |
| | SORL1 | SORL1 isoform 1. (2118 aa) |
| | ENSPPYP00000004644 | annotation not available (118 aa) |
| | USP5 | Ubiquitin carboxyl-terminal hydrolase 5; Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys- 48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity (By similarity). (840 aa) |
| | GABARAPL1 | Gamma-aminobutyric acid receptor-associated protein-like 1. (85 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | PRICKLE1 | Prickle planar cell polarity protein 1. (831 aa) |
| | RNF41 | E3 ubiquitin-protein ligase NRDP1; Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progeni [...] (317 aa) |
| | LRP1 | LRP1 isoform 1. (4377 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa) |
| | TMTC3 | TMTC3 isoform 1. (894 aa) |
| | LOC100436554 | Disintegrin and metalloproteinase domain-containing protein 1-like. (837 aa) |
| | RNFT2 | RING finger and transmembrane domain-containing protein 2. (436 aa) |
| | FBXW8 | FBXW8 isoform 2. (596 aa) |
| | FOXO1 | FOXO1 isoform 1. (654 aa) |
| | HECTD1 | HECT domain E3 ubiquitin protein ligase 1. (2610 aa) |
| | PSMC6 | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa) |
| | SOCS4 | Suppressor of cytokine signaling 4; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity). (373 aa) |
| | DACT1 | Dishevelled binding antagonist of beta catenin 1. (837 aa) |
| | PSEN1 | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (463 aa) |
| | ATXN3 | ATXN3 isoform 7. (334 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (413 aa) |
| | NEDD4 | E3 ubiquitin-protein ligase. (937 aa) |
| | OAZ2 | Ornithine decarboxylase antizyme 2; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (By similarity). Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity). (177 aa) |
| | PIAS1 | PIAS1 isoform 1. (683 aa) |
| | ARIH1 | RBR-type E3 ubiquitin transferase. (557 aa) |
| | SNX33 | Sorting nexin. (572 aa) |
| | FBXO22 | F-box only protein 22; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome- dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function (By similarity). (405 aa) |
| | DET1 | DET1 isoform 5. (472 aa) |
| | LOC100445631 | GABARAPL1 isoform 2. (113 aa) |
| | FURIN | Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa) |
| | CR201_G0054585 | AXIN1 isoform 6. (551 aa) |
| | STUB1 | STIP1 homology and U-box containing protein 1. (303 aa) |
| | ELOB | ELOB isoform 1. (160 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (603 aa) |
| | NUPR1 | NUPR1 isoform 3. (68 aa) |
| | NKD1 | NKD inhibitor of WNT signaling pathway 1. (470 aa) |
| | HERPUD1 | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein; Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway. (391 aa) |
| | CBFA2T3 | CBFA2T3 isoform 1. (630 aa) |
| | VPS35 | Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa) |
| | RILP | RILP isoform 2. (400 aa) |
| | GABARAP | Gamma-aminobutyric acid receptor-associated protein-like 1; Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity); Belongs to the ATG8 family. (117 aa) |
| | PSMC5 | PSMC5 isoform 2; Belongs to the AAA ATPase family. (406 aa) |
| | AXIN2 | AXIN2 isoform 1. (843 aa) |
| | SOX9 | SRY-box transcription factor 9. (509 aa) |
| | GGA3 | GGA3 isoform 1. (716 aa) |
| | CSNK1D | Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, dete [...] (404 aa) |
| | RNFT1 | Ring finger protein, transmembrane 1. (434 aa) |
| | ENSPPYP00000009926 | annotation not available (409 aa) |
| | OSBPL7 | Oxysterol-binding protein; Belongs to the OSBP family. (842 aa) |
| | SNF8 | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (279 aa) |
| | CLUL1 | Clusterin; Belongs to the clusterin family. (498 aa) |
| | SMAD7 | Mothers against decapentaplegic homolog. (426 aa) |
| | TMEM259 | TMEM259 isoform 1. (595 aa) |
| | APC2 | APC2 isoform 1. (2148 aa) |
| | OAZ1 | OAZ1 isoform 1. (227 aa) |
| | SGTA | Small glutamine rich tetratricopeptide repeat containing alpha. (313 aa) |
| | FZR1 | FZR1 isoform 4. (420 aa) |
| | SIRT6 | SIRT6 isoform 1. (355 aa) |
| | CR201_G0051644 | MARCH2 isoform 3. (157 aa) |
| | LDLR | LDLR isoform 3. (815 aa) |
| | FBXW9 | F-box and WD repeat domain containing 9. (458 aa) |
| | RAD23A | RAD23A isoform 1. (350 aa) |
| | HAMP | Hepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity); Belongs to the hepcidin family. (85 aa) |
| | PSMC4 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa) |
| | EGLN2 | T0155508 isoform 1. (407 aa) |
| | GSK3A | Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa) |
| | NOP53 | Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (445 aa) |
| | HSPBP1 | HSPBP1 isoform 1. (240 aa) |
| | DDRGK1 | DDRGK domain containing 1. (314 aa) |
| | CSNK2A1 | CSNK2A1 isoform 1; Belongs to the protein kinase superfamily. (391 aa) |
| | TRIB3 | TRIB3 isoform 1. (358 aa) |
| | ITCH | E3 ubiquitin-protein ligase. (849 aa) |
| | AURKA | AURKA isoform 10; Belongs to the protein kinase superfamily. (404 aa) |
| | KCNE2 | Potassium voltage-gated channel subfamily E regulatory subunit 2. (123 aa) |
| | XBP1 | X-box binding protein 1. (262 aa) |
| | CR201_G0024440 | RHBDD3 isoform 1. (237 aa) |
| | RNF185 | E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UB [...] (192 aa) |
| | GGA1 | GGA1 isoform 1. (634 aa) |
| | LOC100447547 | T0085674 isoform 1; Belongs to the protein kinase superfamily. (416 aa) |
| | SGSM3 | SGSM3 isoform 1. (744 aa) |
| | RBX1 | RBX1 isoform 1. (108 aa) |
| | CR201_G0043010 | SH3RF3 isoform 1. (650 aa) |
| | IL1B | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa) |
| | SOCS5 | Suppressor of cytokine signaling 5. (536 aa) |
| | TRIB2 | Tribbles homolog 2; Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily. (343 aa) |
| | RNF144A | RBR-type E3 ubiquitin transferase. (292 aa) |
| | LRP2 | LRP2 isoform 1. (4512 aa) |
| | NFE2L2 | NFE2L2 isoform 2. (606 aa) |
| | BARD1 | BARD1 isoform 3. (777 aa) |
| | DNAJB2 | DNAJB2 isoform 1. (298 aa) |
| | RHBDD1 | Rhomboid-related protein 4; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfe [...] (318 aa) |
| | MKRN2 | Makorin ring finger protein 2. (416 aa) |
| | RAB7A | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (208 aa) |
| | GSK3B | GSK3B isoform 2; Belongs to the protein kinase superfamily. (380 aa) |
| | CBLB | Cbl proto-oncogene B. (982 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (473 aa) |
| | ARIH2 | RBR-type E3 ubiquitin transferase. (456 aa) |
| | PPP2R3A | PPP2R3A isoform 2. (529 aa) |
| | TIPARP | TCDD-inducible poly [ADP-ribose] polymerase. (657 aa) |
| | USP13 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (831 aa) |
| | FBXL5 | F-box/LRR-repeat protein 5; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued (By similarity). (664 aa) |
| | RCHY1 | Ring finger and CHY zinc finger domain containing 1. (261 aa) |
| | BBS7 | Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa) |
| | SH3D19 | SH3D19 isoform 6. (568 aa) |
| | FBXW7 | FBXW7 isoform 8. (627 aa) |
| | ASB5 | Ankyrin repeat and SOCS box containing 5. (329 aa) |
| | NKD2 | NKD2 isoform 1. (455 aa) |
| | LPCAT1 | Lysophosphatidylcholine acyltransferase 1. (534 aa) |
| | DAB2 | DAB adaptor protein 2. (770 aa) |
| | CDC20B | CDC20B isoform 4. (518 aa) |
| | PLK2 | Serine/threonine-protein kinase PLK2; Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 an [...] (685 aa) |
| | RNF180 | E3 ubiquitin-protein ligase RNF180; E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2. (579 aa) |
| | RNF14 | RBR-type E3 ubiquitin transferase. (474 aa) |
| | NDFIP1 | Nedd4 family interacting protein 1. (221 aa) |
| | SH3RF2 | SH3 domain containing ring finger 2. (729 aa) |
| | CREBRF | CREBRF isoform 1. (639 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | MYLIP | Myosin regulatory light chain interacting protein. (445 aa) |
| | RNF144B | RBR-type E3 ubiquitin transferase. (303 aa) |
| | GPLD1 | GPLD1 isoform 2. (779 aa) |
| | TNF | Tumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family. (233 aa) |
| | BAG6 | BCL2 associated athanogene 6. (1126 aa) |
| | TREM2 | TREM2 isoform 1. (202 aa) |
| | GCLC | Glutamate-cysteine ligase catalytic subunit. (637 aa) |
| | BAG2 | BCL2 associated athanogene 2. (211 aa) |
| | CR201_G0047659 | RBR-type E3 ubiquitin transferase. (219 aa) |
| | TNFAIP3 | TNFAIP3 isoform 1. (790 aa) |
| | VIP | VIP isoform 2. (151 aa) |
| | EZR | EZR isoform 1. (586 aa) |
| | CR201_G0036895 | PRKN isoform 8. (335 aa) |
| | ZFAND2A | AN1-type zinc finger protein 2A. (193 aa) |
| | ENSPPYP00000019816 | annotation not available (197 aa) |
| | PSMC2 | 26S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (433 aa) |
| | CAV1 | Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...] (178 aa) |
| | NUB1 | NUB1 isoform 2. (662 aa) |
| | CLU | Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (415 aa) |
| | ADAM9 | ADAM metallopeptidase domain 9. (819 aa) |
| | SOX17 | SRY-box transcription factor 17. (416 aa) |
| | TRIB1 | Tribbles pseudokinase 1. (372 aa) |
| | VPS28 | Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (205 aa) |
| | VCP | Transitional endoplasmic reticulum ATPase isoform X1. (806 aa) |
| | IL33 | Interleukin-33; Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (By similarity); Belongs to the IL-1 family. Highly divergent. (270 aa) |
| | UBQLN1 | Ubiquilin-1; Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin- proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a lin [...] (577 aa) |
| | TRIM32 | Tripartite motif containing 32. (653 aa) |
| | DAB2IP | DAB2IP isoform 2. (1130 aa) |
| | ZER1 | Protein zer-1 homolog; Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N- myristoylation; Belongs to the [...] (730 aa) |
| | ABCA2 | ABCA2 isoform 9. (2330 aa) |
| | RACK1 | RACK1 isoform 13. (372 aa) |
| | ASB9 | Ankyrin repeat and SOCS box containing 9. (262 aa) |
| | UBQLN2 | UBQLN2 isoform 1. (624 aa) |
| | AMER1 | APC membrane recruitment protein 1. (1136 aa) |
| | MSN | MSN isoform 6. (577 aa) |
| | TAF1 | Transcription initiation factor TFIID subunit. (1755 aa) |
| | PSMD10 | Proteasome 26S subunit, non-ATPase 10. (226 aa) |
| | CUL4B | CUL4B isoform 4; Belongs to the cullin family. (843 aa) |
| | GPC3 | GPC3 isoform 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa) |
| | FMR1 | Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Plays a role in the alternative splicing of its own mRNA. Plays a role in mRNA nuclear export. Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons. Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 [...] (590 aa) |
| | VGLL4 | VGLL4 isoform 12. (296 aa) |
| | SIRT2 | NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtu [...] (389 aa) |
| | LRRK2 | LRRK2 isoform 3. (1560 aa) |
| | ANKIB1 | RBR-type E3 ubiquitin transferase. (1089 aa) |
| | APC | Adenomatous polyposis coli protein isoform X2. (2861 aa) |
| | SNX9 | Sorting nexin. (618 aa) |
| | PSMC1 | Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa) |
| | CR201_G0044109-2 | RACK1 isoform 22. (230 aa) |
| | ECSCR | ECSCR isoform 1. (170 aa) |
| | CR201_G0029825 | ZNF613 isoform 7. (516 aa) |
| | FAF1 | Fas associated factor 1. (650 aa) |
