STRINGSTRING
PTPRC PTPRC TNFSF4 TNFSF4 MAD2L2 MAD2L2 SHLD2 SHLD2 KMT5B KMT5B STAT6 STAT6 TP53BP1 TP53BP1 EXOSC6 EXOSC6 TBX21 TBX21 TGFB1 TGFB1 KMT5C KMT5C CR201_G0038354 CR201_G0038354 MSH2 MSH2 RIF1 RIF1 ENSPPYP00000014637 ENSPPYP00000014637 HMCES HMCES MLH1 MLH1 TFRC TFRC NSD2 NSD2 IL2 IL2 IL4 IL4 PAXIP1 PAXIP1 EXOSC3 EXOSC3 CLCF1 CLCF1 SHLD1 SHLD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPRCPTPRC isoform 2. (1267 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
SHLD2Shieldin complex subunit 2; Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. (904 aa)
KMT5BLysine methyltransferase 5B. (885 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
TP53BP1TP53BP1 isoform 3. (1976 aa)
EXOSC6Exosome complex component MTR3. (271 aa)
TBX21T-box transcription factor 21. (535 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
KMT5CKMT5C isoform 2. (462 aa)
CR201_G0038354CD40 isoform 1. (168 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (850 aa)
RIF1Replication timing regulatory factor 1. (2471 aa)
ENSPPYP00000014637annotation not available (137 aa)
HMCESAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (351 aa)
MLH1MLH1 isoform 1. (725 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). (760 aa)
NSD2NSD2 isoform 1. (1433 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (153 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
PAXIP1PAX interacting protein 1. (1071 aa)
EXOSC3Exosome component 3. (275 aa)
CLCF1Cardiotrophin-like cytokine factor 1 isoform X3. (182 aa)
SHLD1C20orf196 isoform 1. (205 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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