STRINGSTRING
RAB12 RAB12 STXBP2 STXBP2 NDRG4 NDRG4 RAB3D RAB3D STX10 STX10 UNC13A UNC13A RAB3A RAB3A PPFIA3 PPFIA3 ENSPPYP00000011868 ENSPPYP00000011868 EXOC8 EXOC8 SNPH SNPH ENSPPYP00000022364 ENSPPYP00000022364 RABEPK RABEPK STX17 STX17 UNC13B UNC13B TSNARE1 TSNARE1 EXOC4 EXOC4 CFTR CFTR CAV2 CAV2 YKT6 YKT6 STX1A STX1A STX11 STX11 BVES BVES EXOC2 EXOC2 CPLX2 CPLX2 RAB3C RAB3C EXOC3 EXOC3 USO1 USO1 SCFD2 SCFD2 EXOC1 EXOC1 PLEK PLEK EXOC6B EXOC6B STX16 STX16 KCNB1 KCNB1 RAB13 RAB13 STXBP3 STXBP3 RAB3B RAB3B VAMP3 VAMP3 EXOC6 EXOC6 CTBP2 CTBP2 STX5 STX5 STX3 STX3 SYTL2 SYTL2 VPS11 VPS11 CEP83 CEP83 STX2 STX2 EXOC5 EXOC5 RAB15 RAB15 VTI1B VTI1B VPS18 VPS18 CR201_G0046277 CR201_G0046277 ENSPPYP00000007360 ENSPPYP00000007360 UNC13C UNC13C CLN3 CLN3 STX1B STX1B STX4 STX4 STX8 STX8 EXOC7 EXOC7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAB12RAB12 isoform 1. (340 aa)
STXBP2Syntaxin binding protein 2. (592 aa)
NDRG4NDRG4 isoform 31. (401 aa)
RAB3DRAB3D isoform 1. (194 aa)
STX10STX10 isoform 6; Belongs to the syntaxin family. (249 aa)
UNC13AUNC13A isoform 4. (1518 aa)
RAB3ARas-related protein Rab-3A. (203 aa)
PPFIA3PPFIA3 isoform 1. (1047 aa)
ENSPPYP00000011868annotation not available (149 aa)
EXOC8EXOC8 isoform 1. (728 aa)
SNPHSNPH isoform 2. (535 aa)
ENSPPYP00000022364annotation not available (138 aa)
RABEPKRABEPK isoform 2. (363 aa)
STX17STX17 isoform 1; Belongs to the syntaxin family. (302 aa)
UNC13BUNC13B isoform 5. (1610 aa)
TSNARE1TSNARE1 isoform 1. (511 aa)
EXOC4EXOC4 isoform 2. (974 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1480 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (162 aa)
YKT6YKT6 v-SNARE homolog; Belongs to the synaptobrevin family. (198 aa)
STX1ASyntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...] (259 aa)
STX11STX11 isoform 1; Belongs to the syntaxin family. (287 aa)
BVESBlood vessel epicardial substance. (360 aa)
EXOC2Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (924 aa)
CPLX2CPLX2 isoform 1. (134 aa)
RAB3CRAB3C, member RAS oncogene family. (227 aa)
EXOC3EXOC3 isoform 1. (745 aa)
USO1USO1 isoform 2. (969 aa)
SCFD2SCFD2 isoform 1; Belongs to the STXBP/unc-18/SEC1 family. (684 aa)
EXOC1EXOC1 isoform 1. (912 aa)
PLEKPLEK isoform 1. (350 aa)
EXOC6BExocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (810 aa)
STX16STX16-NPEPL1 isoform 1; Belongs to the syntaxin family. (308 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
RAB13RAB13 isoform 2. (203 aa)
STXBP3STXBP3 isoform 1; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
RAB3BRAB3B, member RAS oncogene family. (219 aa)
VAMP3Vesicle associated membrane protein 3. (100 aa)
EXOC6Exocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (797 aa)
CTBP2CTBP2 isoform 10. (985 aa)
STX5STX5 isoform 1; Belongs to the syntaxin family. (355 aa)
STX3STX3 isoform 3; Belongs to the syntaxin family. (289 aa)
SYTL2SYTL2 isoform 4. (935 aa)
VPS11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (941 aa)
CEP83CEP83 isoform 2. (701 aa)
STX2STX2 isoform 2; Belongs to the syntaxin family. (263 aa)
EXOC5EXOC5 isoform 1. (710 aa)
RAB15RAB15 isoform 2. (207 aa)
VTI1BVesicle transport through interaction with t-SNAREs 1B. (232 aa)
VPS18VPS18 core subunit of CORVET and HOPS complexes. (973 aa)
CR201_G0046277Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (143 aa)
ENSPPYP00000007360annotation not available (418 aa)
UNC13CUNC13C isoform 1. (1180 aa)
CLN3Battenin. (438 aa)
STX1BSTX1B isoform 1; Belongs to the syntaxin family. (590 aa)
STX4STX4 isoform 4; Belongs to the syntaxin family. (296 aa)
STX8STX8 isoform 2. (236 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (732 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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