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| | BMPR1B | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (492 aa) |
| | FZD4 | FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa) |
| | PGR | PGR isoform 1. (935 aa) |
| | DRD2 | DRD2 isoform 2; Belongs to the G-protein coupled receptor 1 family. (461 aa) |
| | USP2 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (564 aa) |
| | KDM5A | KDM5A isoform 1. (1729 aa) |
| | NDUFA9 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (381 aa) |
| | HEBP1 | HEBP1 isoform 1. (188 aa) |
| | ENSPPYP00000004926 | annotation not available (398 aa) |
| | BHLHE41 | BHLHE41 isoform 1. (265 aa) |
| | ARNTL2 | Aryl hydrocarbon receptor nuclear translocator like 2. (636 aa) |
| | DNM1L | DNM1L isoform 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (686 aa) |
| | SP1 | Sp1 transcription factor. (786 aa) |
| | MMP19 | MMP19 isoform 8. (506 aa) |
| | TIMELESS | TIMELESS isoform 2. (1211 aa) |
| | TPH2 | Tryptophan hydroxylase 2. (490 aa) |
| | CRY1 | Cryptochrome circadian regulator 1. (586 aa) |
| | PPP1CC | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa) |
| | ID1 | Inhibitor of DNA binding 1, HLH protein. (155 aa) |
| | NCOR2 | NCOR2 isoform 6. (2461 aa) |
| | PSPC1 | PSPC1 isoform 6. (521 aa) |
| | ENOX1 | ENOX1 isoform 1. (687 aa) |
| | FBXL3 | F-box and leucine rich repeat protein 3. (428 aa) |
| | FAM155A | Family with sequence similarity 155 member A. (459 aa) |
| | CUL4A | CUL4A isoform 5; Belongs to the cullin family. (759 aa) |
| | METTL3 | Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa) |
| | PRMT5 | Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H and may regulate its transcriptional elongation properties (By similarity). Mono- and dimethylates arginine resi [...] (637 aa) |
| | NKX2-1 | NKX2-1 isoform 1. (401 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | CIPC | CLOCK-interacting pacemaker; Transcriptional repressor which may act as a negative- feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in knockout mice showed that CIPC is not critially required for basic circadian clock. (342 aa) |
| | MTA1 | MTA1 isoform 4. (697 aa) |
| | UBE3A | Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (849 aa) |
| | GPR176 | GPR176 isoform 2. (562 aa) |
| | CR201_G0046045 | TYRO3 isoform 2. (738 aa) |
| | RORA | RORA isoform 12. (555 aa) |
| | PML | PML isoform 4. (869 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1273 aa) |
| | ENSPPYP00000007573 | annotation not available (745 aa) |
| | SCAPER | SCAPER isoform 10. (1400 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1367 aa) |
| | CREBBP | CREBBP isoform 1. (2328 aa) |
| | USP7 | USP7 isoform 8; Belongs to the peptidase C19 family. (1082 aa) |
| | KDM8 | Lysine demethylase 8. (416 aa) |
| | MMP2 | MMP2 isoform 3. (559 aa) |
| | AGRP | Agouti related neuropeptide. (132 aa) |
| | ZFHX3 | ZFHX3 isoform 7. (3164 aa) |
| | SERPINF1 | Serpin family F member 1; Belongs to the serpin family. (418 aa) |
| | MYBBP1A | MYBBP1A isoform 3. (1166 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | HES7 | Hes family bHLH transcription factor 7. (225 aa) |
| | PER1 | PER1 isoform 10. (1110 aa) |
| | NCOR1 | NCOR1 isoform 1. (2467 aa) |
| | RAI1 | RAI1 isoform 1. (1908 aa) |
| | SREBF1 | SREBF1 isoform 2. (1153 aa) |
| | NOS2 | Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa) |
| | SLC6A4 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (595 aa) |
| | CDK5R1 | Cyclin-dependent kinase 5 activator. (307 aa) |
| | ZNF830 | Zinc finger protein 830. (372 aa) |
| | HLF | HLF isoform 1. (295 aa) |
| | NAGLU | N-acetyl-alpha-glucosaminidase. (743 aa) |
| | STAT5B | Signal transducer and activator of transcription. (788 aa) |
| | TOP2A | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1553 aa) |
| | NR1D1 | NR1D1 isoform 1. (612 aa) |
| | ZPBP2 | ZPBP2 isoform 1. (336 aa) |
| | DDX5 | Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] (614 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
| | AANAT | AANAT isoform 2. (207 aa) |
| | CSNK1D | Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, dete [...] (404 aa) |
| | NGFR | NGFR isoform 1. (407 aa) |
| | TYMS | Thymidylate synthetase. (338 aa) |
| | TNFRSF11A | TNFRSF11A isoform 5. (616 aa) |
| | AMH | AMH isoform 1. (561 aa) |
| | SIRT6 | SIRT6 isoform 1. (355 aa) |
| | FBXW9 | F-box and WD repeat domain containing 9. (458 aa) |
| | CRTC1 | CREB regulated transcription coactivator 1. (634 aa) |
| | CR201_G0044035 | AXL isoform 5. (583 aa) |
| | RELB | RELB isoform 1. (581 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (692 aa) |
| | PROKR2 | Prokineticin receptor 2. (349 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | ROBO2 | ROBO2 isoform 6. (1384 aa) |
| | PTN | PTN isoform 1. (168 aa) |
| | CR201_G0044109-2 | RACK1 isoform 22. (230 aa) |
| | PLEKHA1 | PLEKHA1 isoform 4. (383 aa) |
| | MYCBP2 | MYCBP2 isoform 1. (3875 aa) |
| | NCOA2 | Nuclear receptor coactivator. (1464 aa) |
| | ID4 | Inhibitor of DNA binding 4, HLH protein. (161 aa) |
| | EZH2 | EZH2 isoform 5. (704 aa) |
| | PASD1 | PASD1 isoform 1. (773 aa) |
| | ENOX2 | Ecto-NOX disulfide-thiol exchanger 2. (610 aa) |
| | ENSPPYP00000023117 | annotation not available (175 aa) |
| | OGT | OGT isoform 1. (1045 aa) |
| | NONO | Non-POU domain-containing octamer-binding protein; DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclea [...] (471 aa) |
| | ENSPPYP00000022846 | annotation not available (149 aa) |
| | HUWE1 | HUWE1 isoform 1. (4373 aa) |
| | KDM5C | KDM5C isoform 2. (1278 aa) |
| | MAGED1 | MAGE family member D1. (778 aa) |
| | SUV39H1 | Histone-lysine N-methyltransferase SUV39H1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric re [...] (411 aa) |
| | USP9X | Ubiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2554 aa) |
| | ENSPPYP00000022480 | annotation not available (181 aa) |
| | RACK1 | RACK1 isoform 13. (372 aa) |
| | SETX | SETX isoform 1. (2678 aa) |
| | ASS1 | ASS1 isoform 1. (359 aa) |
| | NR5A1 | NR5A1 isoform 2. (461 aa) |
| | GRIN3A | GRIN3A isoform 1; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1120 aa) |
| | NTRK2 | Tyrosine-protein kinase receptor. (838 aa) |
| | RORB | RORB isoform 1. (516 aa) |
| | KLF9 | Kruppel like factor 9. (244 aa) |
| | HAS2 | HAS2 isoform 1. (511 aa) |
| | KLF10 | KLF10 isoform 1. (528 aa) |
| | PRKDC | PRKDC isoform 1; Belongs to the PI3/PI4-kinase family. (3972 aa) |
| | EGR3 | EGR3 isoform 1. (387 aa) |
| | CCAR2 | Cell cycle and apoptosis regulator protein 2; Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53- mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part [...] (917 aa) |
| | PIWIL2 | Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (973 aa) |
| | NAMPT | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (491 aa) |
| | CDK5 | Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa) |
| | NOS3 | NOS3 isoform 2. (833 aa) |
| | CASP2 | CASP2 isoform 1; Belongs to the peptidase C14A family. (452 aa) |
| | PAX4 | PAX4 isoform 1. (351 aa) |
| | KCND2 | KCND2 isoform 1; Belongs to the potassium channel family. (630 aa) |
| | ENSPPYP00000020084 | annotation not available (168 aa) |
| | AHR | T0067486 isoform 1. (850 aa) |
| | TWIST1 | Twist family bHLH transcription factor 1. (203 aa) |
| | CBX3 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the [...] (183 aa) |
| | INHBA | Inhibin subunit beta A. (426 aa) |
| | ADCY1 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (636 aa) |
| | DDC | DDC isoform 1. (491 aa) |
| | CLDN4 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa) |
| | ESR1 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa) |
| | HDAC2 | Histone deacetylase 2. (580 aa) |
| | CGA | Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (116 aa) |
| | HCRTR2 | Hypocretin receptor 2; Belongs to the G-protein coupled receptor 1 family. (444 aa) |
| | NFYA | Nuclear transcription factor Y subunit alpha. (347 aa) |
| | BTBD9 | BTB domain containing 9. (641 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | FBXW11 | FBXW11 isoform 1. (489 aa) |
| | SLIT3 | SLIT3 isoform 2. (1552 aa) |
| | HDAC3 | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activi [...] (428 aa) |
| | NUDT12 | Peroxisomal NADH pyrophosphatase NUDT12; Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. (506 aa) |
| | PAM | Peptidylglycine alpha-amidating monooxygenase. (973 aa) |
| | HOMER1 | Homer scaffold protein 1. (354 aa) |
| | CARTPT | CART prepropeptide. (116 aa) |
| | ATF5 | ATF5 isoform 1. (147 aa) |
| | PRKAA1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] (559 aa) |
| | SRD5A1 | 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (168 aa) |
| | MTNR1A | Melatonin receptor 1A; Belongs to the G-protein coupled receptor 1 family. (352 aa) |
| | NPY5R | Neuropeptide Y receptor Y5. (445 aa) |
| | FBXW7 | FBXW7 isoform 8. (627 aa) |
| | NOCT | NOCT isoform 2. (431 aa) |
| | MTTP | MTTP isoform 1. (892 aa) |
| | CCDC90B | Coiled-coil domain containing 90B. (254 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (384 aa) |
| | HNRNPD | Heterogeneous nuclear ribonucleoprotein D. (355 aa) |
| | EREG | EREG isoform 1. (169 aa) |
| | AFP | Alpha fetoprotein. (609 aa) |
| | CLOCK | Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...] (846 aa) |
| | GABRB1 | Gamma-aminobutyric acid type A receptor beta1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (474 aa) |
| | PPARGC1A | PPARG coactivator 1 alpha. (798 aa) |
| | SLIT2 | SLIT2 isoform 5. (1503 aa) |
| | ADIPOQ | Adiponectin, C1Q and collagen domain containing. (244 aa) |
| | C3orf70 | C3orf70 isoform 1. (248 aa) |
| | NLGN1 | NLGN1 isoform 2. (823 aa) |
| | PTX3 | PTX3 isoform 1. (381 aa) |
| | GPR149 | GPR149 isoform 1. (731 aa) |
| | SIAH2 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa) |
| | SPSB4 | SplA/ryanodine receptor domain and SOCS box containing 4. (273 aa) |
| | KAT2B | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (755 aa) |
| | NR1D2 | NR1D2 isoform 1. (504 aa) |
| | IMPDH2 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa) |
| | PROK2 | PROK2 isoform 2. (129 aa) |
| | BHLHE40 | Class E basic helix-loop-helix protein 40; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK- ARNTL/BMAL1|ARNTL2/ [...] (412 aa) |
| | OXTR | Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (389 aa) |
| | TIMP4 | TIMP metallopeptidase inhibitor 4. (224 aa) |
| | PPARG | Peroxisome proliferator-activated receptor gamma. (477 aa) |
| | GSK3B | GSK3B isoform 2; Belongs to the protein kinase superfamily. (380 aa) |
| | PER2 | PER2 isoform 2. (1226 aa) |
| | CR201_G0032376 | RESP18 isoform 1. (184 aa) |
| | PTPRN | PTPRN isoform 1. (960 aa) |
| | CREB1 | CREB1 isoform 1. (341 aa) |
| | KCNH7 | KCNH7 isoform 2. (1196 aa) |
| | TNFAIP6 | TNF alpha induced protein 6. (277 aa) |
| | ID2 | DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] (134 aa) |
| | ROCK2 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa) |
| | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] (327 aa) |
| | CYP1B1 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa) |
| | LHCGR | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (702 aa) |
| | FSHR | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa) |
| | GFPT1 | GFPT1 isoform 1. (780 aa) |
| | LOC100438930 | MDK isoform 6. (143 aa) |
| | NPAS2 | NPAS2 isoform 1. (889 aa) |
| | NMS | NMS isoform 1. (153 aa) |
| | PPARA | Peroxisome proliferator activated receptor alpha. (474 aa) |
| | TEF | TEF transcription factor, PAR bZIP family member. (273 aa) |
| | EP300 | EP300 isoform 1. (2380 aa) |
| | ATF4 | ATF4 isoform 1. (352 aa) |
| | LOC100447547 | T0085674 isoform 1; Belongs to the protein kinase superfamily. (416 aa) |
| | SRRD | SRR1 domain containing. (325 aa) |
| | TRPM2 | TRPM2 isoform 3. (1302 aa) |
| | DYRK1A | DYRK1A isoform 7. (674 aa) |
| | ADAMTS1 | ADAMTS1 isoform 1. (970 aa) |
| | NRIP1 | NRIP1 isoform 1. (1141 aa) |
| | ENSPPYP00000012589 | Putative nuclear receptor corepressor 1-like protein NCOR1P1. (101 aa) |
| | MC3R | Melanocortin 3 receptor. (323 aa) |
| | ADNP | Activity dependent neuroprotector homeobox. (1102 aa) |
| | HNF4A | HNF4A isoform 1. (462 aa) |
| | TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (768 aa) |
| | SRC | Tyrosine-protein kinase. (553 aa) |
| | AHCY | Adenosylhomocysteinase. (432 aa) |
| | HNRNPU | HNRNPU isoform 9. (780 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa) |
| | PROX1 | Prospero homeobox 1. (737 aa) |
| | DTL | DTL isoform 2. (659 aa) |
| | KISS1 | KISS1 isoform 2. (147 aa) |
| | KDM5B | KDM5B isoform 2. (1404 aa) |
| | DHX9 | ATP-dependent RNA helicase A; Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing. Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA a [...] (1269 aa) |
| | NTRK1 | Tyrosine-protein kinase receptor. (796 aa) |
| | RORC | Nuclear receptor ROR-gamma; Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respective [...] (642 aa) |
| | CIART | CIART isoform 3. (284 aa) |
| | NHLH2 | Nescient helix-loop-helix 2. (135 aa) |
| | RPE65 | Retinoid isomerohydrolase RPE65. (533 aa) |
| | PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] (552 aa) |
| | CR201_G0015676 | THRAP3 isoform 1. (560 aa) |
| | SFPQ | Splicing factor proline and glutamine rich. (707 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] (482 aa) |
| | NR0B2 | Nuclear receptor subfamily 0 group B member 2. (257 aa) |
| | ID3 | Inhibitor of DNA binding 3, HLH protein. (119 aa) |
| | KIAA2013 | KIAA2013 isoform 1. (634 aa) |
| | GPR157 | GPR157 isoform 1. (318 aa) |
| | PER3 | PER3 isoform 5. (1166 aa) |
| | CR201_G0044109 | RACK1 isoform 5. (346 aa) |
| | SUV39H2 | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (410 aa) |
| | GDF10 | Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | OPN4 | OPN4 isoform 2. (478 aa) |
| | SGPL1 | Sphingosine-1-phosphate lyase 1; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (By similarity). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establish [...] (568 aa) |
| | SIRT1 | SIRT1 isoform 1. (746 aa) |
| | CDK1 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] (297 aa) |
| | PTEN | Pongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | HTR7 | HTR7 isoform 3; Belongs to the G-protein coupled receptor 1 family. (459 aa) |
| | BTRC | BTRC isoform 2. (605 aa) |
| | NFKB2 | NFKB2 isoform 4. (868 aa) |
| | DRD4 | DRD4 isoform 1; Belongs to the G-protein coupled receptor 1 family. (417 aa) |
| | TH | TH isoform 6. (522 aa) |
| | PPP1CA | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa) |
| | KDM2A | KDM2A isoform 12. (723 aa) |
| | RBM4B | RNA binding motif protein 4B. (359 aa) |
| | RBM4 | RBM4 isoform 12. (361 aa) |
| | DDB1 | DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiqui [...] (1135 aa) |
| | CRY2 | Cryptochrome circadian regulator 2. (593 aa) |
| | FSHB | Follicle stimulating hormone beta subunit. (129 aa) |
| | LGR4 | LGR4 isoform 1. (947 aa) |
| | GAS2 | Growth arrest specific 2. (313 aa) |
| | TPH1 | Tryptophan hydroxylase 1. (444 aa) |
| | ARNTL | Aryl hydrocarbon receptor nuclear translocator-like protein 1; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressur [...] (583 aa) |
| | CAVIN3 | Caveolae associated protein 3. (261 aa) |
