(44 nodes) Thymus development network (Pongo abelii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
	CRKL	CRKL isoform 1. (251 aa)
	MAPK1	Mitogen-activated protein kinase 1 isoform X1. (158 aa)
	ABL1	Tyrosine-protein kinase. (948 aa)
	CR201_G0027499	ABL1 isoform 3. (48 aa)
	SLC46A2	Solute carrier family 46 member 2. (475 aa)
	FOXE1	FOXE1 isoform 1. (371 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (460 aa)
	BRAF	BRAF isoform 1. (765 aa)
	HOXA3	HOXA3 isoform 3. (443 aa)
	MAD1L1	Mitotic arrest deficient 1 like 1. (718 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
	SRF	Serum response factor. (508 aa)
	JARID2	JARID2 isoform 1. (1246 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	HAND2	HAND2 isoform 1. (217 aa)
	HES1	HES1 isoform 1. (198 aa)
	CTNNB1	CTNNB1 isoform 2. (781 aa)
	CACNB4	CACNB4 isoform 16. (487 aa)
	BCL2L11	BCL2L11 isoform 4. (138 aa)
	ENSPPYP00000013398	annotation not available (195 aa)
	TBX1	TBX1 isoform 2. (213 aa)
	ENSPPYP00000012819	annotation not available (444 aa)
	MAFB	MAF bZIP transcription factor B. (323 aa)
	ASXL1	ASXL transcriptional regulator 1. (1476 aa)
	PAX1	PAX1 isoform 1. (447 aa)
	MAP2K2	MAP2K2 isoform 6. (213 aa)
	BCL2	BCL2 isoform 1. (238 aa)
	FOXN1	FOXN1 isoform 2. (648 aa)
	CTC1	CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...] (1214 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa)
	CCNB2	CCNB2 isoform 1; Belongs to the cyclin family. (398 aa)
	BCL11B	BCL11B isoform 1. (893 aa)
	PSEN1	Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (463 aa)
	ZBTB1	Zinc finger and BTB domain containing 1. (644 aa)
	SIX4	SIX4 isoform 1. (698 aa)
	SIX1	SIX homeobox 1. (284 aa)
	RIPK3	Receptor interacting serine/threonine kinase 3. (518 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3003 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	GATA3	GATA binding protein 3. (444 aa)
	CR201_G0015558	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (363 aa)
	LMO4	LIM domain only 4. (165 aa)
	PBX1	PBX homeobox 1. (430 aa)

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ASXL1	ENSPPYP00000022265	ENSPPYP00000012182	Tyrosine-protein kinase.	ASXL transcriptional regulator 1.	0.522
ABL1	ATM	ENSPPYP00000022265	ENSPPYP00000004403	Tyrosine-protein kinase.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.975
ABL1	BCL2	ENSPPYP00000022265	ENSPPYP00000010339	Tyrosine-protein kinase.	BCL2 isoform 1.	0.510
ABL1	CRKL	ENSPPYP00000022265	ENSPPYP00000024295	Tyrosine-protein kinase.	CRKL isoform 1.	0.995
ABL1	CTNNB1	ENSPPYP00000022265	ENSPPYP00000015644	Tyrosine-protein kinase.	CTNNB1 isoform 2.	0.804
ABL1	ENSPPYP00000013398	ENSPPYP00000022265	ENSPPYP00000013398	Tyrosine-protein kinase.	annotation not available	0.641
ABL1	MAPK1	ENSPPYP00000022265	ENSPPYP00000023664	Tyrosine-protein kinase.	Mitogen-activated protein kinase 1 isoform X1.	0.641
ABL1	MAPK3	ENSPPYP00000022265	ENSPPYP00000008184	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.426
ABL1	PBX1	ENSPPYP00000022265	ENSPPYP00000000671	Tyrosine-protein kinase.	PBX homeobox 1.	0.556
ASXL1	ABL1	ENSPPYP00000012182	ENSPPYP00000022265	ASXL transcriptional regulator 1.	Tyrosine-protein kinase.	0.522
ASXL1	CTC1	ENSPPYP00000012182	ENSPPYP00000008942	ASXL transcriptional regulator 1.	CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...]	0.649
ASXL1	JARID2	ENSPPYP00000012182	ENSPPYP00000018173	ASXL transcriptional regulator 1.	JARID2 isoform 1.	0.612
ATM	ABL1	ENSPPYP00000004403	ENSPPYP00000022265	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.975
ATM	BCL2	ENSPPYP00000004403	ENSPPYP00000010339	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BCL2 isoform 1.	0.530
ATM	BRAF	ENSPPYP00000004403	ENSPPYP00000020265	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRAF isoform 1.	0.662
ATM	CR201_G0027499	ENSPPYP00000004403	ENSPPYP00000022079	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ABL1 isoform 3.	0.764
ATM	CTC1	ENSPPYP00000004403	ENSPPYP00000008942	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...]	0.456
ATM	CTNNB1	ENSPPYP00000004403	ENSPPYP00000015644	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	CTNNB1 isoform 2.	0.494
ATM	MAPK3	ENSPPYP00000004403	ENSPPYP00000008184	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.405
ATM	TGFBR1	ENSPPYP00000004403	ENSPPYP00000021783	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.538