STRINGSTRING
PAX2 PAX2 RBM20 RBM20 FGFR2 FGFR2 WNT11 WNT11 BMP4 BMP4 MESP1 MESP1 EMP2 EMP2 MAP2K2 MAP2K2 ENSPPYP00000013398 ENSPPYP00000013398 TBR1 TBR1 LRP2 LRP2 GLI3 GLI3 HOXA3 HOXA3 SMARCD3 SMARCD3 SHH SHH SOX17 SOX17 RDH10 RDH10 EXT1 EXT1 DKFZp468G2216 DKFZp468G2216 BMPR1A BMPR1A MAPK1 MAPK1 FOXH1 FOXH1 WNT5A WNT5A CTNNB1 CTNNB1 TGFBR2 TGFBR2 TP63 TP63 NKX3-2 NKX3-2 FGF10 FGF10 ISL1 ISL1 MEF2C MEF2C LEMD2 LEMD2 MAPK3 MAPK3 NOG NOG AXIN2 AXIN2 GATA6 GATA6 ENSPPYP00000011451 ENSPPYP00000011451 NTF4 NTF4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAX2PAX2 isoform 3. (388 aa)
RBM20RBM20 isoform 1. (1191 aa)
FGFR2Fibroblast growth factor receptor. (656 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (269 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
MAP2K2MAP2K2 isoform 6. (213 aa)
ENSPPYP00000013398annotation not available (195 aa)
TBR1T-box brain transcription factor 1. (682 aa)
LRP2LRP2 isoform 1. (4512 aa)
GLI3GLI3 isoform 3. (1580 aa)
HOXA3HOXA3 isoform 3. (443 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (460 aa)
SOX17SRY-box transcription factor 17. (416 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
EXT1Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). (746 aa)
DKFZp468G2216AR isoform 8. (388 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (158 aa)
FOXH1FOXH1 isoform 1. (366 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (473 aa)
CTNNB1CTNNB1 isoform 2. (781 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
NKX3-2NKX3-2 isoform 1. (333 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ISL1ISL1 isoform 1. (349 aa)
MEF2CMyocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (441 aa)
LEMD2LEMD2 isoform 1. (479 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
AXIN2AXIN2 isoform 1. (843 aa)
GATA6GATA6 isoform 1. (580 aa)
ENSPPYP00000011451annotation not available (257 aa)
NTF4Neurotrophin 4. (210 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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