(42 nodes) Embryonic cranial skeleton morphogenesis network (Pongo abelii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRRX1	PRRX1 isoform 3. (216 aa)
	SLC39A1	SLC39A1 isoform 1. (324 aa)
	TBX15	T-box transcription factor 15. (496 aa)
	ALX3	ALX homeobox 3. (343 aa)
	NODAL	Nodal growth differentiation factor. (347 aa)
	CR201_G0023542	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (166 aa)
	FGFR2	Fibroblast growth factor receptor. (656 aa)
	TULP3	TULP3 isoform 2. (439 aa)
	CHST11	Carbohydrate sulfotransferase. (352 aa)
	MMP14	Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which i [...] (582 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	SIX1	SIX homeobox 1. (284 aa)
	SIX4	SIX4 isoform 1. (698 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	IFT140	Intraflagellar transport 140. (1462 aa)
	IRX5	Iroquois homeobox 5. (483 aa)
	LHX1	LHX1 isoform 1. (406 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
	EIF4A3	Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. (411 aa)
	SMAD2	Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] (467 aa)
	TBX1	TBX1 isoform 2. (213 aa)
	SIX2	SIX homeobox 2. (291 aa)
	DLX2	Distal-less homeobox 2. (328 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2563 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	WDR19	WDR19 isoform 1. (1273 aa)
	NIPBL	Nipped-B protein. (2684 aa)
	NDST1	N-deacetylase and N-sulfotransferase 1. (882 aa)
	TFAP2A	Transcription factor AP-2 alpha. (439 aa)
	RUNX2	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (589 aa)
	MTHFD1L	MTHFD1L isoform 1. (978 aa)
	GLI3	GLI3 isoform 3. (1580 aa)
	HOXA2	HOXA2 isoform 1. (374 aa)
	TWIST1	Twist family bHLH transcription factor 1. (203 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	MMP16	MMP16 isoform 1. (606 aa)
	CR201_G0028244	GRHL2 isoform 1. (493 aa)
	PAX5	PAX5 isoform 1. (391 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
	MED12	MED12 isoform 3. (2178 aa)
	HOXA1	HOXA1 isoform 2. (197 aa)

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALX3	TBX15	ENSPPYP00000001225	ENSPPYP00000001128	ALX homeobox 3.	T-box transcription factor 15.	0.585
BMP4	CR201_G0023542	ENSPPYP00000006620	ENSPPYP00000003008	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.677
BMP4	DLX2	ENSPPYP00000006620	ENSPPYP00000014439	Bone morphogenetic protein 4.	Distal-less homeobox 2.	0.518
BMP4	FGFR2	ENSPPYP00000006620	ENSPPYP00000003165	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.528
BMP4	RUNX2	ENSPPYP00000006620	ENSPPYP00000018641	Bone morphogenetic protein 4.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.733
BMP4	SMAD2	ENSPPYP00000006620	ENSPPYP00000010275	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...]	0.727
BMP4	SMAD3	ENSPPYP00000006620	ENSPPYP00000007465	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.637
BMP4	TGFBR1	ENSPPYP00000006620	ENSPPYP00000021783	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.751
BMP4	TGFBR2	ENSPPYP00000006620	ENSPPYP00000015718	Bone morphogenetic protein 4.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.507
CR201_G0023542	BMP4	ENSPPYP00000003008	ENSPPYP00000006620	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.677
CR201_G0023542	DLX2	ENSPPYP00000003008	ENSPPYP00000014439	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Distal-less homeobox 2.	0.497
CR201_G0023542	FGFR2	ENSPPYP00000003008	ENSPPYP00000003165	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.959
CR201_G0023542	GLI3	ENSPPYP00000003008	ENSPPYP00000019741	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	GLI3 isoform 3.	0.467
CR201_G0023542	HOXA2	ENSPPYP00000003008	ENSPPYP00000019850	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	HOXA2 isoform 1.	0.474
CR201_G0023542	RUNX2	ENSPPYP00000003008	ENSPPYP00000018641	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.508
CR201_G0023542	TGFB3	ENSPPYP00000003008	ENSPPYP00000006835	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.524
CR201_G0023542	TWIST1	ENSPPYP00000003008	ENSPPYP00000019900	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Twist family bHLH transcription factor 1.	0.468
DLX2	BMP4	ENSPPYP00000014439	ENSPPYP00000006620	Distal-less homeobox 2.	Bone morphogenetic protein 4.	0.518
DLX2	CR201_G0023542	ENSPPYP00000014439	ENSPPYP00000003008	Distal-less homeobox 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.497
DLX2	HOXA2	ENSPPYP00000014439	ENSPPYP00000019850	Distal-less homeobox 2.	HOXA2 isoform 1.	0.414