STRINGSTRING
PTEN PTEN ENSPPYP00000024222 ENSPPYP00000024222 CR201_G0011157 CR201_G0011157 ID4 ID4 PLP1 PLP1 MED12 MED12 ABCA2 ABCA2 NOTCH1 NOTCH1 LPAR1 LPAR1 NTRK2 NTRK2 LYN LYN NRG1 NRG1 CLU CLU ENSPPYP00000020450 ENSPPYP00000020450 SHH SHH RHEB RHEB CDK5 CDK5 PTPRZ1 PTPRZ1 GLI3 GLI3 NSUN5 NSUN5 ENSPPYP00000019595 ENSPPYP00000019595 ENSPPYP00000018739 ENSPPYP00000018739 TPPP TPPP NKX6-1 NKX6-1 PRDM8 PRDM8 EIF2B5 EIF2B5 CTNNB1 CTNNB1 HDAC11 HDAC11 BOK BOK DLX2 DLX2 DLX1 DLX1 GPR17 GPR17 EIF2B4 EIF2B4 MAL MAL SOX10 SOX10 OLIG2 OLIG2 B4GALT5 B4GALT5 NKX2-2 NKX2-2 ERCC2 ERCC2 TGFB1 TGFB1 MAG MAG B4GALT6 B4GALT6 ENSPPYP00000009901 ENSPPYP00000009901 SOX9 SOX9 ERBB2 ERBB2 CNP CNP CNTNAP1 CNTNAP1 NF1 NF1 SUZ12 SUZ12 ASPA ASPA FA2H FA2H SOX8 SOX8 CSK CSK EIF2B2 EIF2B2 SLC8A3 SLC8A3 NKX2-1 NKX2-1 TRPC4 TRPC4 WASF3 WASF3 EIF2B1 EIF2B1 ASCL1 ASCL1 NEUROD4 NEUROD4 CNTN1 CNTN1 TENM4 TENM4 SOX6 SOX6 PAX6 PAX6 MYRF MYRF ACY3 ACY3 NKX6-2 NKX6-2 BNIP3 BNIP3 HDAC1 HDAC1 EIF2B3 EIF2B3 CDKN2C CDKN2C TSPAN2 TSPAN2 KCNJ10 KCNJ10 NCSTN NCSTN SOX13 SOX13 CNTN2 CNTN2 DUSP10 DUSP10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTENPongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ENSPPYP00000024222annotation not available (138 aa)
CR201_G0011157PAX6 isoform 63. (257 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
PLP1Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin (By similarity). (277 aa)
MED12MED12 isoform 3. (2178 aa)
ABCA2ABCA2 isoform 9. (2330 aa)
NOTCH1NOTCH1 isoform 1. (2107 aa)
LPAR1Lysophosphatidic acid receptor 1. (364 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
LYNTyrosine-protein kinase. (512 aa)
NRG1NRG1 isoform 10. (692 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (415 aa)
ENSPPYP00000020450annotation not available (153 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (460 aa)
RHEBRHEB isoform 1. (167 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
PTPRZ1PTPRZ1 isoform 1. (2317 aa)
GLI3GLI3 isoform 3. (1580 aa)
NSUN5NSUN5 isoform 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (376 aa)
ENSPPYP00000019595annotation not available (298 aa)
ENSPPYP00000018739annotation not available (186 aa)
TPPPTPPP isoform 1. (219 aa)
NKX6-1NKX6-1 isoform 2. (367 aa)
PRDM8PRDM8 isoform 10. (302 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (721 aa)
CTNNB1CTNNB1 isoform 2. (781 aa)
HDAC11HDAC11 isoform 10. (370 aa)
BOKBCL2 family apoptosis regulator BOK. (212 aa)
DLX2Distal-less homeobox 2. (328 aa)
DLX1Distal-less homeobox 1. (255 aa)
GPR17G protein-coupled receptor 17; Belongs to the G-protein coupled receptor 1 family. (367 aa)
EIF2B4EIF2B4 isoform 1; Belongs to the eIF-2B alpha/beta/delta subunits family. (553 aa)
MALMal, T cell differentiation protein. (153 aa)
SOX10SOX10 isoform 2. (436 aa)
OLIG2Oligodendrocyte transcription factor 2. (323 aa)
B4GALT5B4GALT5 isoform 1. (344 aa)
NKX2-2NKX2-2 isoform 1. (273 aa)
ERCC2ERCC2 isoform 1. (729 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
MAGMAG isoform 1. (627 aa)
B4GALT6Beta-1,4-galactosyltransferase 6. (382 aa)
ENSPPYP00000009901Polycomb protein SUZ12-like isoform X6. (88 aa)
SOX9SRY-box transcription factor 9. (509 aa)
ERBB2Receptor protein-tyrosine kinase. (1256 aa)
CNP2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family. (420 aa)
CNTNAP1Contactin associated protein 1. (1384 aa)
NF1NF1 isoform 6. (2838 aa)
SUZ12SUZ12 isoform 1. (490 aa)
ASPAAspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids (By similarity). (313 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (263 aa)
SOX8SRY-box transcription factor 8. (446 aa)
CSKTyrosine-protein kinase. (437 aa)
EIF2B2EIF2B2 isoform 1; Belongs to the eIF-2B alpha/beta/delta subunits family. (351 aa)
SLC8A3SLC8A3 isoform 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (804 aa)
NKX2-1NKX2-1 isoform 1. (401 aa)
TRPC4TRPC4 isoform 8. (893 aa)
WASF3WASP family member 3. (499 aa)
EIF2B1Translation initiation factor eIF-2B subunit alpha; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP; Belongs to the eIF-2B alpha/beta/delta subunits family. (305 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (235 aa)
NEUROD4Neurogenic differentiation factor. (331 aa)
CNTN1CNTN1 isoform 3. (1018 aa)
TENM4TENM4 isoform 2. (2794 aa)
SOX6Transcription factor SOX-6; Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation (By similarity). (855 aa)
PAX6PAX6 isoform 13. (266 aa)
MYRFMYRF isoform 1. (1162 aa)
ACY3ACY3 isoform 1. (315 aa)
NKX6-2NKX6-2 isoform 2. (277 aa)
BNIP3BNIP3 isoform 1. (256 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] (482 aa)
EIF2B3EIF2B3 isoform 1. (396 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
TSPAN2Tetraspanin. (221 aa)
KCNJ10Potassium voltage-gated channel subfamily J member 10. (379 aa)
NCSTNNCSTN isoform 1. (639 aa)
SOX13SRY-box transcription factor 13. (623 aa)
CNTN2CNTN2 isoform 10. (1039 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.