STRINGSTRING
TAZ TAZ HNRNPU HNRNPU RYR2 RYR2 ACTN2 ACTN2 EGLN1 EGLN1 WNT3A WNT3A TGFB2 TGFB2 PROX1 PROX1 TNNT2 TNNT2 LMNA LMNA GJA5 GJA5 COL11A1 COL11A1 S1PR1 S1PR1 TGFBR3 TGFBR3 ACADM ACADM CR201_G0015558 CR201_G0015558 SLC9A1 SLC9A1 CDC42 CDC42 NPPB NPPB NPPA NPPA NEBL NEBL BMPR1A BMPR1A PTEN PTEN ANKRD1 ANKRD1 NRAP NRAP FGFR2 FGFR2 LRRC10B LRRC10B MYBPC3 MYBPC3 CSRP3 CSRP3 TENM4 TENM4 VWA5A VWA5A PKP2 PKP2 ARID2 ARID2 LRRC10 LRRC10 MYL2 MYL2 TBX5 TBX5 TBX3 TBX3 GJB6 GJB6 FGF9 FGF9 SGCG SGCG ENSPPYP00000006185 ENSPPYP00000006185 ADPRHL1 ADPRHL1 MYH7 MYH7 SAV1 SAV1 BMP4 BMP4 ASB2 ASB2 GREM1 GREM1 ALDH1A2 ALDH1A2 TPM1 TPM1 HCN4 HCN4 AKAP13 AKAP13 MEF2A MEF2A MESP1 MESP1 ALPK3 ALPK3 NPRL3 NPRL3 MYH11 MYH11 IRX3 IRX3 ZFPM1 ZFPM1 MYOCD MYOCD IFT20 IFT20 NOG NOG CACNA1G CACNA1G GJC1 GJC1 RARA RARA TCAP TCAP MED1 MED1 TBX2 TBX2 GATA6 GATA6 DSG2 DSG2 FHOD3 FHOD3 SMAD7 SMAD7 SMAD4 SMAD4 ALPK2 ALPK2 SIRT6 SIRT6 CALR CALR TGFB1 TGFB1 PPP1R13L PPP1R13L ENSPPYP00000011486 ENSPPYP00000011486 VWA5B1 VWA5B1 TNNI1 TNNI1 ENSPPYP00000012166 ENSPPYP00000012166 BMP7 BMP7 GATA5 GATA5 CXADR CXADR CR201_G0046772 CR201_G0046772 CBY1 CBY1 ENSPPYP00000013364 ENSPPYP00000013364 FHL2 FHL2 BMP10 BMP10 SLC8A1 SLC8A1 CR201_G0021858 CR201_G0021858 ACVR1 ACVR1 LRP2 LRP2 HEG1 HEG1 CAV3 CAV3 ADAMTS9 ADAMTS9 WNT5A WNT5A TNNC1 TNNC1 TREX1 TREX1 MYL3 MYL3 SCN5A SCN5A RARB RARB DIPK2A DIPK2A CR201_G0007803 CR201_G0007803 ENSPPYP00000016046 ENSPPYP00000016046 VWA5B2 VWA5B2 HOPX HOPX SGCB SGCB PDLIM5 PDLIM5 ENSPPYP00000016868 ENSPPYP00000016868 SMAD1 SMAD1 EDNRA EDNRA SORBS2 SORBS2 ISL1 ISL1 PTCD2 PTCD2 MEF2C MEF2C WNT8A WNT8A PDGFRB PDGFRB HAND1 HAND1 SGCD SGCD CR201_G0004819 CR201_G0004819 MAML1 MAML1 FOXC1 FOXC1 DSP DSP JARID2 JARID2 SRF SRF BMP5 BMP5 ENSPPYP00000018739 ENSPPYP00000018739 TBX18 TBX18 BVES BVES ATG5 ATG5 GJA1 GJA1 HEY2 HEY2 MYL10 MYL10 TBX20 TBX20 WNT2 WNT2 GATA4 GATA4 SGCZ SGCZ NKX2-6 NKX2-6 ADRA1A ADRA1A NRG1 NRG1 CHD7 CHD7 MSC MSC PLN PLN HEY1 HEY1 ZFPM2 ZFPM2 PLEC PLEC TGFBR1 TGFBR1 ENG ENG TSC1 TSC1 NOTCH1 NOTCH1 ZIC3 ZIC3 MAP2K4 MAP2K4 KDM6B KDM6B NDRG4 NDRG4 ENSPPYP00000023839 ENSPPYP00000023839 BMP2 BMP2 FOXH1 FOXH1 DLL4 DLL4 WT1 WT1 TNNI3 TNNI3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TAZTafazzin family protein; Some isoforms may be involved in cardiolipin metabolism. (262 aa)
HNRNPUHNRNPU isoform 9. (780 aa)
RYR2RYR2 isoform 1. (4546 aa)
ACTN2ACTN2 isoform 1. (887 aa)
EGLN1Egl-9 family hypoxia inducible factor 1. (426 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (385 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
PROX1Prospero homeobox 1. (737 aa)
TNNT2TNNT2 isoform 18. (295 aa)
LMNALMNA isoform 2; Belongs to the intermediate filament family. (664 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
COL11A1COL11A1 isoform 4. (1573 aa)
S1PR1S1PR1 isoform 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
TGFBR3TGFBR3 isoform 1. (859 aa)
ACADMAcyl-CoA dehydrogenase medium chain. (454 aa)
CR201_G0015558CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (363 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
CDC42Cell division cycle 42. (191 aa)
NPPBNatriuretic peptide B. (134 aa)
NPPANatriuretic peptide A. (159 aa)
NEBLNEBL isoform 5. (1014 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PTENPongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ANKRD1ANKRD1 isoform 1. (319 aa)
NRAPNRAP isoform 1. (1729 aa)
FGFR2Fibroblast growth factor receptor. (656 aa)
LRRC10BLRRC10B isoform 1. (142 aa)
MYBPC3MYBPC3 isoform 2. (1265 aa)
CSRP3CSRP3 isoform 1. (233 aa)
TENM4TENM4 isoform 2. (2794 aa)
VWA5AVWA5A isoform 1. (821 aa)
PKP2PKP2 isoform 2. (829 aa)
ARID2AT-rich interaction domain 2. (1836 aa)
LRRC10LRRC10 isoform 1. (277 aa)
MYL2MYL2 isoform 2. (146 aa)
TBX5T-box transcription factor 5. (518 aa)
TBX3T-box transcription factor 3. (743 aa)
GJB6Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (261 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SGCGSGCG isoform 1. (291 aa)
ENSPPYP00000006185annotation not available (303 aa)
ADPRHL1[Protein ADP-ribosylarginine] hydrolase-like protein 1; Belongs to the ADP-ribosylglycohydrolase family. (352 aa)
MYH7MYH7 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1896 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
ASB2ASB2 isoform 6. (553 aa)
GREM1Gremlin. (184 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
TPM1TPM1 isoform 2; Belongs to the tropomyosin family. (326 aa)
HCN4HCN4 isoform 1. (869 aa)
AKAP13AKAP13 isoform 5. (2833 aa)
MEF2AMyocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylate [...] (494 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (269 aa)
ALPK3ALPK3 isoform 1. (1908 aa)
NPRL3NPRL3 isoform 6. (540 aa)
MYH11MYH11 isoform 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1794 aa)
IRX3IRX3 isoform 1. (436 aa)
ZFPM1ZFPM1 isoform 1. (344 aa)
MYOCDMYOCD isoform 1. (986 aa)
IFT20IFT20 isoform 6. (158 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2286 aa)
GJC1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
RARARARA isoform 2. (460 aa)
TCAPTCAP isoform 1. (167 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for [...] (1586 aa)
TBX2TBX2 isoform 1. (588 aa)
GATA6GATA6 isoform 1. (580 aa)
DSG2DSG2 isoform 1. (1072 aa)
FHOD3FHOD3 isoform 5. (1352 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ALPK2ALPK2 isoform 1. (2170 aa)
SIRT6SIRT6 isoform 1. (355 aa)
CALRCalreticulin. (417 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
PPP1R13LPPP1R13L isoform 1. (407 aa)
ENSPPYP00000011486annotation not available (168 aa)
VWA5B1VWA5B1 isoform 1. (343 aa)
TNNI1TNNI1 isoform 1. (166 aa)
ENSPPYP00000012166annotation not available (413 aa)
BMP7Bone morphogenetic protein 7. (365 aa)
GATA5GATA binding protein 5. (397 aa)
CXADRCoxsackievirus and adenovirus receptor homolog; Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induc [...] (365 aa)
CR201_G0046772MYO18B isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2110 aa)
CBY1Chibby family member 1, beta catenin antagonist. (169 aa)
ENSPPYP00000013364annotation not available (267 aa)
FHL2FHL2 isoform 4. (459 aa)
BMP10BMP10 isoform 1. (424 aa)
SLC8A1SLC8A1 isoform 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
CR201_G0021858NEB isoform 1. (2717 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
LRP2LRP2 isoform 1. (4512 aa)
HEG1HEG1 isoform 1. (1386 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa)
ADAMTS9ADAMTS9 isoform 1. (1933 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (473 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
TREX1Three prime repair exonuclease 1. (369 aa)
MYL3Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium (By similarity). (195 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1523 aa)
RARBRARB isoform 2. (526 aa)
DIPK2ADivergent protein kinase domain 2A. (430 aa)
CR201_G0007803SHOX2 isoform 5. (151 aa)
ENSPPYP00000016046annotation not available (124 aa)
VWA5B2VWA5B2 isoform 1. (1000 aa)
HOPXHOPX isoform 2. (87 aa)
SGCBBeta-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. (318 aa)
PDLIM5PDLIM5 isoform 3. (596 aa)
ENSPPYP00000016868annotation not available (85 aa)
SMAD1Mothers against decapentaplegic homolog. (73 aa)
EDNRAEDNRA isoform 1; Belongs to the G-protein coupled receptor 1 family. (425 aa)
SORBS2SORBS2 isoform 7. (1298 aa)
ISL1ISL1 isoform 1. (349 aa)
PTCD2Pentatricopeptide repeat-containing protein 2, mitochondrial; Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function; Belongs to the PTCD2 family. (344 aa)
MEF2CMyocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (441 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
SGCDSarcoglycan delta. (289 aa)
CR201_G0004819NKX2-5 isoform 1. (210 aa)
MAML1MAML1 isoform 1. (911 aa)
FOXC1FOXC1 isoform 1. (332 aa)
DSPDSP isoform 1. (2871 aa)
JARID2JARID2 isoform 1. (1246 aa)
SRFSerum response factor. (508 aa)
BMP5BMP5 isoform 1. (453 aa)
ENSPPYP00000018739annotation not available (186 aa)
TBX18T-box transcription factor 18. (607 aa)
BVESBlood vessel epicardial substance. (360 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] (275 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
MYL10Myosin light chain 10. (226 aa)
TBX20TBX20 isoform 1. (447 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
GATA4GATA binding protein 4. (442 aa)
SGCZSGCZ isoform 1. (310 aa)
NKX2-6NKX2-6 isoform 1. (301 aa)
ADRA1AAdrenoceptor alpha 1A. (427 aa)
NRG1NRG1 isoform 10. (692 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2997 aa)
MSCMSC isoform 1. (206 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
ZFPM2ZFPM2 isoform 1. (1152 aa)
PLECPLEC isoform 2. (2298 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
ENGENG isoform 3. (668 aa)
TSC1TSC1 isoform 8. (1157 aa)
NOTCH1NOTCH1 isoform 1. (2107 aa)
ZIC3Zic family member 3. (466 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
KDM6BKDM6B isoform 2. (942 aa)
NDRG4NDRG4 isoform 31. (401 aa)
ENSPPYP00000023839annotation not available (519 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
FOXH1FOXH1 isoform 1. (366 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
WT1WT1 isoform 2. (320 aa)
TNNI3TNNI3 isoform 3. (210 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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