STRINGSTRING
ADD2 ADD2 JAM2 JAM2 GCNT1 GCNT1 EXT1 EXT1 TNF TNF GOLPH3 GOLPH3 CX3CR1 CX3CR1 PODXL2 PODXL2 ITGA4 ITGA4 MADCAM1 MADCAM1 ROCK1 ROCK1 SPN SPN SELPLG SELPLG ITGB7 ITGB7 VCAM1 VCAM1 SELP SELP SELL SELL SELE SELE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADD2Beta-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity). Belongs to the aldolase class II family. Adducin subfamily. (726 aa)
JAM2Junctional adhesion molecule 2. (298 aa)
GCNT1Glucosaminyl (N-acetyl) transferase 1. (428 aa)
EXT1Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). (746 aa)
TNFTumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family. (233 aa)
GOLPH3Golgi phosphoprotein 3. (298 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
PODXL2PODXL2 isoform 1. (523 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
MADCAM1MADCAM1 isoform 4. (345 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1299 aa)
SPNSPN isoform 1. (400 aa)
SELPLGSELPLG isoform 1. (402 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (797 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
SELPSELP isoform 2. (829 aa)
SELLL-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (385 aa)
SELESELE isoform 3. (601 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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