(49 nodes) Detection of mechanical stimulus network (Pongo abelii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NTRK1	Tyrosine-protein kinase receptor. (796 aa)
	COL11A1	COL11A1 isoform 4. (1573 aa)
	CXCL12	CXCL12 isoform 2; Belongs to the intercrine alpha (chemokine CxC) family. (93 aa)
	PCDH15	PCDH15 isoform 18. (1163 aa)
	PKD2L1	PKD2L1 isoform 1. (803 aa)
	PDZD7	PDZ domain-containing protein 7; In cochlear developing hair cells, essential in organizing the USH2 complex at stereocilia ankle links. Blocks inhibition of adenylate cyclase activity mediated by ADGRV1. (477 aa)
	KCNQ1	KCNQ1 isoform 3; Belongs to the potassium channel family. (301 aa)
	KCNK4	Potassium two pore domain channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (393 aa)
	CSRP3	CSRP3 isoform 1. (233 aa)
	CHRNA10	Cholinergic receptor nicotinic alpha 10 subunit. (450 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	BACE1	Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa)
	KCNA1	Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
	PAWR	PAWR isoform 3. (340 aa)
	PTPRQ	PTPRQ isoform 5. (154 aa)
	LRRIQ1	LRRIQ1 isoform 2. (1721 aa)
	CR201_G0045973	STRC isoform 2. (1473 aa)
	PKD1	PKD1 isoform 1. (4255 aa)
	PKD1L3	PKD1L3 isoform 1. (1697 aa)
	CR201_G0048356	Piezo-type mechanosensitive ion channel component. (1806 aa)
	JUP	JUP isoform 1. (670 aa)
	TCAP	TCAP isoform 1. (167 aa)
	CR201_G0051251	PIEZO2 isoform 13. (391 aa)
	PIEZO2	PIEZO2 isoform 5. (619 aa)
	CR201_G0051251-2	Piezo-type mechanosensitive ion channel component. (1245 aa)
	HPN	Serine protease hepsin non-catalytic chain; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL. Plays a role in the proteolytic processing of ACE2 (By similarity). (417 aa)
	MKKS	McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin; Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis. Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis. (570 aa)
	TMC2	Transmembrane channel-like protein. (905 aa)
	SCN1A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2009 aa)
	PJVK	DFNB59 isoform 1. (352 aa)
	SERPINE2	SERPINE2 isoform 5; Belongs to the serpin family. (409 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa)
	CTNNB1	CTNNB1 isoform 2. (781 aa)
	REST	REST isoform 6. (1250 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (770 aa)
	PKD2	PKD2 isoform 1. (968 aa)
	CHRNA9	CHRNA9 isoform 1. (479 aa)
	ITGA2	ITGA2 isoform 1; Belongs to the integrin alpha chain family. (1157 aa)
	ADGRV1	ADGRV1 isoform 3; Belongs to the G-protein coupled receptor 2 family. (6076 aa)
	PKD2L2	Polycystin 2 like 2, transient receptor potential cation channel. (624 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	TMEM120A	Transmembrane protein 120A. (343 aa)
	ASIC3	ASIC3 isoform 5; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (549 aa)
	TRPA1	TRPA1 isoform 1; Belongs to the transient receptor (TC 1.A.4) family. (1119 aa)
	PTK2	PTK2 isoform 11; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1095 aa)
	PHF24	PHD finger protein 24. (210 aa)
	TMC1	Transmembrane channel-like protein. (761 aa)
	WHRN	WHRN isoform 2. (907 aa)
	ENSPPYP00000022280	annotation not available (192 aa)

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRV1	CR201_G0045973	ENSPPYP00000017471	ENSPPYP00000007275	ADGRV1 isoform 3; Belongs to the G-protein coupled receptor 2 family.	STRC isoform 2.	0.442
ADGRV1	PCDH15	ENSPPYP00000017471	ENSPPYP00000002826	ADGRV1 isoform 3; Belongs to the G-protein coupled receptor 2 family.	PCDH15 isoform 18.	0.789
ADGRV1	PDZD7	ENSPPYP00000017471	ENSPPYP00000002994	ADGRV1 isoform 3; Belongs to the G-protein coupled receptor 2 family.	PDZ domain-containing protein 7; In cochlear developing hair cells, essential in organizing the USH2 complex at stereocilia ankle links. Blocks inhibition of adenylate cyclase activity mediated by ADGRV1.	0.832
ADGRV1	SCN1A	ENSPPYP00000017471	ENSPPYP00000014396	ADGRV1 isoform 3; Belongs to the G-protein coupled receptor 2 family.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.463
ADGRV1	TMC1	ENSPPYP00000017471	ENSPPYP00000021607	ADGRV1 isoform 3; Belongs to the G-protein coupled receptor 2 family.	Transmembrane channel-like protein.	0.603
ADGRV1	WHRN	ENSPPYP00000017471	ENSPPYP00000021890	ADGRV1 isoform 3; Belongs to the G-protein coupled receptor 2 family.	WHRN isoform 2.	0.965
ASIC3	PIEZO2	ENSPPYP00000020388	ENSPPYP00000010099	ASIC3 isoform 5; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	PIEZO2 isoform 5.	0.436
ASIC3	TRPA1	ENSPPYP00000020388	ENSPPYP00000020939	ASIC3 isoform 5; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.	TRPA1 isoform 1; Belongs to the transient receptor (TC 1.A.4) family.	0.475
BACE1	FYN	ENSPPYP00000004482	ENSPPYP00000018952	Beta-secretase 1; Belongs to the peptidase A1 family.	Tyrosine-protein kinase.	0.414
BACE1	NTRK1	ENSPPYP00000004482	ENSPPYP00000000808	Beta-secretase 1; Belongs to the peptidase A1 family.	Tyrosine-protein kinase receptor.	0.463
BACE1	SCN1A	ENSPPYP00000004482	ENSPPYP00000014396	Beta-secretase 1; Belongs to the peptidase A1 family.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.470
CAV3	CSRP3	ENSPPYP00000015308	ENSPPYP00000003932	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	CSRP3 isoform 1.	0.522
CAV3	CTNNB1	ENSPPYP00000015308	ENSPPYP00000015644	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	CTNNB1 isoform 2.	0.431
CAV3	FYN	ENSPPYP00000015308	ENSPPYP00000018952	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Tyrosine-protein kinase.	0.930
CAV3	JUP	ENSPPYP00000015308	ENSPPYP00000009456	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	JUP isoform 1.	0.431
CAV3	KCNQ1	ENSPPYP00000015308	ENSPPYP00000003405	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	KCNQ1 isoform 3; Belongs to the potassium channel family.	0.487
CAV3	TCAP	ENSPPYP00000015308	ENSPPYP00000009530	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	TCAP isoform 1.	0.519
CHRNA10	CHRNA9	ENSPPYP00000004154	ENSPPYP00000017081	Cholinergic receptor nicotinic alpha 10 subunit.	CHRNA9 isoform 1.	0.916
CHRNA10	CR201_G0045973	ENSPPYP00000004154	ENSPPYP00000007275	Cholinergic receptor nicotinic alpha 10 subunit.	STRC isoform 2.	0.504
CHRNA9	CHRNA10	ENSPPYP00000017081	ENSPPYP00000004154	CHRNA9 isoform 1.	Cholinergic receptor nicotinic alpha 10 subunit.	0.916