(33 nodes) Cartilage development involved in endochondral bone morphogenesis network (Pongo abelii)

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Known Interactions

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Predicted Interactions

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Your Input:
	GHR	Growth hormone receptor. (638 aa)
	IFT80	IFT80 isoform 1. (777 aa)
	CR201_G0007803	SHOX2 isoform 5. (151 aa)
	RARB	RARB isoform 2. (526 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	NPPC	Natriuretic peptide C. (126 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	CR201_G0017164	HOXD11 isoform 2. (143 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	CBS	Cystathionine beta-synthase isoform X1. (294 aa)
	CR201_G0029377	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (454 aa)
	COL1A1	COL1A1 isoform 2. (1463 aa)
	SOX9	SRY-box transcription factor 9. (509 aa)
	AXIN2	AXIN2 isoform 1. (843 aa)
	RARA	RARA isoform 2. (460 aa)
	SMPD3	SMPD3 isoform 1. (629 aa)
	TRIP11	TRIP11 isoform 2. (1979 aa)
	TRPV4	TRPV4 isoform 2; Belongs to the transient receptor (TC 1.A.4) family. (699 aa)
	RARG	RARG isoform 5. (469 aa)
	COL2A1	Collagen type II alpha 1 chain. (1487 aa)
	MMP13	Matrix metallopeptidase 13. (471 aa)
	TSKU	Tsukushi, small leucine rich proteoglycan. (353 aa)
	SERPINH1	Serpin H1; Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen (By similarity). Belongs to the serpin family. (418 aa)
	SCUBE2	SCUBE2 isoform 2. (1073 aa)
	MATN1	MATN1 isoform 1. (460 aa)
	CR201_G0015558	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (363 aa)
	THBS3	THBS3 isoform 4. (836 aa)
	EXT1	Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). (746 aa)
	CER1	CER1 isoform 1. (215 aa)
	COL27A1	COL27A1 isoform 1. (1831 aa)
	STC1	Stanniocalcin 1. (247 aa)
	HOXA11	HOXA11 isoform 2. (315 aa)
	ANXA6	Annexin. (660 aa)

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN2	SOX9	ENSPPYP00000009609	ENSPPYP00000009638	AXIN2 isoform 1.	SRY-box transcription factor 9.	0.467
COL1A1	COL27A1	ENSPPYP00000010031	ENSPPYP00000021885	COL1A1 isoform 2.	COL27A1 isoform 1.	0.531
COL1A1	COL2A1	ENSPPYP00000010031	ENSPPYP00000005079	COL1A1 isoform 2.	Collagen type II alpha 1 chain.	0.603
COL1A1	EXT1	ENSPPYP00000010031	ENSPPYP00000021133	COL1A1 isoform 2.	Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity).	0.439
COL1A1	SERPINH1	ENSPPYP00000010031	ENSPPYP00000004218	COL1A1 isoform 2.	Serpin H1; Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen (By similarity). Belongs to the serpin family.	0.697
COL27A1	COL1A1	ENSPPYP00000021885	ENSPPYP00000010031	COL27A1 isoform 1.	COL1A1 isoform 2.	0.531
COL27A1	COL2A1	ENSPPYP00000021885	ENSPPYP00000005079	COL27A1 isoform 1.	Collagen type II alpha 1 chain.	0.647
COL27A1	SERPINH1	ENSPPYP00000021885	ENSPPYP00000004218	COL27A1 isoform 1.	Serpin H1; Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen (By similarity). Belongs to the serpin family.	0.608
COL2A1	COL1A1	ENSPPYP00000005079	ENSPPYP00000010031	Collagen type II alpha 1 chain.	COL1A1 isoform 2.	0.603
COL2A1	COL27A1	ENSPPYP00000005079	ENSPPYP00000021885	Collagen type II alpha 1 chain.	COL27A1 isoform 1.	0.647
COL2A1	IHH	ENSPPYP00000005079	ENSPPYP00000014741	Collagen type II alpha 1 chain.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.509
COL2A1	MATN1	ENSPPYP00000005079	ENSPPYP00000001876	Collagen type II alpha 1 chain.	MATN1 isoform 1.	0.603
COL2A1	MMP13	ENSPPYP00000005079	ENSPPYP00000004364	Collagen type II alpha 1 chain.	Matrix metallopeptidase 13.	0.662
COL2A1	NPPC	ENSPPYP00000005079	ENSPPYP00000014838	Collagen type II alpha 1 chain.	Natriuretic peptide C.	0.452
COL2A1	SERPINH1	ENSPPYP00000005079	ENSPPYP00000004218	Collagen type II alpha 1 chain.	Serpin H1; Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen (By similarity). Belongs to the serpin family.	0.648
COL2A1	SOX9	ENSPPYP00000005079	ENSPPYP00000009638	Collagen type II alpha 1 chain.	SRY-box transcription factor 9.	0.747
COL2A1	TRIP11	ENSPPYP00000005079	ENSPPYP00000006904	Collagen type II alpha 1 chain.	TRIP11 isoform 2.	0.521
EXT1	COL1A1	ENSPPYP00000021133	ENSPPYP00000010031	Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity).	COL1A1 isoform 2.	0.439
EXT1	IHH	ENSPPYP00000021133	ENSPPYP00000014741	Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity).	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.592
IHH	COL2A1	ENSPPYP00000014741	ENSPPYP00000005079	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Collagen type II alpha 1 chain.	0.509