STRINGSTRING
JAK2 JAK2 RBPMS RBPMS KIAA0319 KIAA0319 BMP6 BMP6 DAB2 DAB2 PPARG PPARG BMPR2 BMPR2 TGFB1 TGFB1 SMAD4 SMAD4 NUP93 NUP93 BMP2 BMP2 CR201_G0034363 CR201_G0034363 TGFB3 TGFB3 BMP4 BMP4 NODAL NODAL BMPR1A BMPR1A PARP1 PARP1 TGFBR1 TGFBR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1132 aa)
RBPMSRNA binding protein, mRNA processing factor. (219 aa)
KIAA0319KIAA0319 isoform 5. (1072 aa)
BMP6BMP6 isoform 1. (510 aa)
DAB2DAB adaptor protein 2. (770 aa)
PPARGPeroxisome proliferator-activated receptor gamma. (477 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
NUP93Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling; Belongs to the nucleoporin interacting component (NIC) family. (819 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
CR201_G0034363SH2B1 isoform 11. (426 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
NODALNodal growth differentiation factor. (347 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (972 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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