STRINGSTRING
ZFPM1 ZFPM1 TP53 TP53 NOG NOG FZD2 FZD2 TBX2 TBX2 MKS1 MKS1 GATA6 GATA6 SMAD7 SMAD7 SMAD4 SMAD4 JAG1 JAG1 BMP7 BMP7 TBX1 TBX1 ACVR1 ACVR1 LRP2 LRP2 BMPR2 BMPR2 NRP2 NRP2 ROBO1 ROBO1 WNT5A WNT5A TGFBR2 TGFBR2 HES1 HES1 CR201_G0040907 CR201_G0040907 NSD2 NSD2 SLIT2 SLIT2 GATA4 GATA4 CHD7 CHD7 HEY1 HEY1 ZFPM2 ZFPM2 TGFBR1 TGFBR1 ENG ENG NOTCH1 NOTCH1 ROBO2 ROBO2 RBM15 RBM15 TGFBR3 TGFBR3 CCN1 CCN1 HEYL HEYL DHRS3 DHRS3 NRP1 NRP1 BMPR1A BMPR1A CR201_G0023542 CR201_G0023542 FGFR2 FGFR2 PROX1 PROX1 TGFB2 TGFB2 EGLN1 EGLN1 SLIT3 SLIT3 CR201_G0004819 CR201_G0004819 CR201_G0047764 CR201_G0047764 BMP5 BMP5 ENSPPYP00000018739 ENSPPYP00000018739 ENSPPYP00000017595 ENSPPYP00000017595 HEY2 HEY2 CITED2 CITED2 TBX20 TBX20 DNAH11 DNAH11 FZD1 FZD1 SEMA3C SEMA3C SMO SMO NOS3 NOS3 ISL1 ISL1 APLNR APLNR PARVA PARVA WNT11 WNT11 TBX5 TBX5 HAND1 HAND1 TBX3 TBX3 SAV1 SAV1 BMP4 BMP4 SMAD6 SMAD6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZFPM1ZFPM1 isoform 1. (344 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
TBX2TBX2 isoform 1. (588 aa)
MKS1MKS1 isoform 7. (343 aa)
GATA6GATA6 isoform 1. (580 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
BMP7Bone morphogenetic protein 7. (365 aa)
TBX1TBX1 isoform 2. (213 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
LRP2LRP2 isoform 1. (4512 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
ROBO1ROBO1 isoform 6. (1612 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (473 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
HES1HES1 isoform 1. (198 aa)
CR201_G0040907FGFRL1 isoform 5. (318 aa)
NSD2NSD2 isoform 1. (1433 aa)
SLIT2SLIT2 isoform 5. (1503 aa)
GATA4GATA binding protein 4. (442 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2997 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
ZFPM2ZFPM2 isoform 1. (1152 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
ENGENG isoform 3. (668 aa)
NOTCH1NOTCH1 isoform 1. (2107 aa)
ROBO2ROBO2 isoform 6. (1384 aa)
RBM15RNA binding motif protein 15. (969 aa)
TGFBR3TGFBR3 isoform 1. (859 aa)
CCN1Cellular communication network factor 1. (381 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CR201_G0023542Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (166 aa)
FGFR2Fibroblast growth factor receptor. (656 aa)
PROX1Prospero homeobox 1. (737 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
EGLN1Egl-9 family hypoxia inducible factor 1. (426 aa)
SLIT3SLIT3 isoform 2. (1552 aa)
CR201_G0004819NKX2-5 isoform 1. (210 aa)
CR201_G0047764Transcription factor SOX. (308 aa)
BMP5BMP5 isoform 1. (453 aa)
ENSPPYP00000018739annotation not available (186 aa)
ENSPPYP00000017595annotation not available (533 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
TBX20TBX20 isoform 1. (447 aa)
DNAH11DNAH11 isoform 2. (3961 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (649 aa)
SEMA3CSemaphorin-3C; Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity). (754 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
NOS3NOS3 isoform 2. (833 aa)
ISL1ISL1 isoform 1. (349 aa)
APLNRAPLNR isoform 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
PARVAPARVA isoform 1. (412 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
TBX5T-box transcription factor 5. (518 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
TBX3T-box transcription factor 3. (743 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SMAD6Mothers against decapentaplegic homolog. (404 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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