STRINGSTRING
SEMA4B SEMA4B ROBO2 ROBO2 EDNRB EDNRB WT1 WT1 OVOL2 OVOL2 FOXH1 FOXH1 LRP6 LRP6 LOXL2 LOXL2 BMP2 BMP2 ENSPPYP00000023667 ENSPPYP00000023667 MAPK1 MAPK1 NOLC1 NOLC1 RPS7 RPS7 FLNA FLNA ZIC3 ZIC3 AMER1 AMER1 OTUD5 OTUD5 AMELX AMELX NOTCH1 NOTCH1 CR201_G0027392 CR201_G0027392 ENG ENG AKNA AKNA TGFBR1 TGFBR1 SEMA4D SEMA4D BNC2 BNC2 SCX SCX ENSPPYP00000021204 ENSPPYP00000021204 HAS2 HAS2 EXT1 EXT1 ZFPM2 ZFPM2 HEY1 HEY1 RDH10 RDH10 SNAI2 SNAI2 CR201_G0033322 CR201_G0033322 FGFR1 FGFR1 NRG1 NRG1 GATA4 GATA4 SHH SHH NOS3 NOS3 EXOC4 EXOC4 SMO SMO WNT16 WNT16 WNT2 WNT2 SEMA3C SEMA3C HGF HGF SEMA3E SEMA3E SEMA3A SEMA3A SEMA3D SEMA3D TWIST1 TWIST1 HOXA5 HOXA5 TBX20 TBX20 RADIL RADIL CITED2 CITED2 TCF21 TCF21 HEY2 HEY2 ENSPPYP00000018739 ENSPPYP00000018739 BMP5 BMP5 PTK7 PTK7 CUL7 CUL7 NOTCH4 NOTCH4 RBM24 RBM24 EDN1 EDN1 FOXC1 FOXC1 FOXF2 FOXF2 HNRNPAB HNRNPAB CR201_G0004819 CR201_G0004819 HAND1 HAND1 ANXA6 ANXA6 TCOF1 TCOF1 PDGFRB PDGFRB WNT8A WNT8A SEMA6A SEMA6A FBXL17 FBXL17 FAM172A FAM172A MEF2C MEF2C ISL1 ISL1 FGF10 FGF10 GDNF GDNF BASP1 BASP1 SEMA5A SEMA5A PDCD6 PDCD6 HAND2 HAND2 SFRP2 SFRP2 EDNRA EDNRA SPRY1 SPRY1 PITX2 PITX2 LEF1 LEF1 PKD2 PKD2 CR201_G0036073 CR201_G0036073 TAPT1 TAPT1 ENSPPYP00000016309 ENSPPYP00000016309 MSX1 MSX1 HES1 HES1 WWTR1 WWTR1 EOMES EOMES TGFBR2 TGFBR2 CTNNB1 CTNNB1 SEMA3F SEMA3F SEMA3B SEMA3B SEMA3G SEMA3G WNT5A WNT5A TASOR TASOR CR201_G0046097 CR201_G0046097 CRELD1 CRELD1 ROBO1 ROBO1 DPPA4 DPPA4 POGLUT1 POGLUT1 GSK3B GSK3B SEMA5B SEMA5B GBX2 GBX2 WNT10A WNT10A FN1 FN1 ERBB4 ERBB4 NRP2 NRP2 BMPR2 BMPR2 STAT1 STAT1 FRZB FRZB ACVR1 ACVR1 EPB41L5 EPB41L5 SEMA4C SEMA4C ROCK2 ROCK2 OSR1 OSR1 SIX2 SIX2 RTN4 RTN4 ACTG2 ACTG2 LOXL3 LOXL3 CR201_G0002974 CR201_G0002974 POLR1B POLR1B ENSPPYP00000013398 ENSPPYP00000013398 DDX17 DDX17 SOX10 SOX10 TBX1 TBX1 GATA5 GATA5 CR201_G0055991 CR201_G0055991 EDN3 EDN3 BMP7 BMP7 ZFP64 ZFP64 SNAI1 SNAI1 FAM83D FAM83D ACTL10 ACTL10 PAX1 PAX1 JAG1 JAG1 TRIM28 TRIM28 TEAD2 TEAD2 DACT3 DACT3 TGFB1 TGFB1 DLL3 DLL3 DAND5 DAND5 NRTN NRTN SEMA6B SEMA6B AMH AMH BCL2 BCL2 SMAD4 SMAD4 SMAD2 SMAD2 CDH2 CDH2 ROCK1 ROCK1 ENSPPYP00000010097 ENSPPYP00000010097 TBX2 TBX2 SOX9 SOX9 DDX5 DDX5 MEOX1 MEOX1 TMEM100 TMEM100 NOG NOG RFLNB RFLNB FOXF1 FOXF1 MAPK3 MAPK3 SOX8 SOX8 MESP1 MESP1 SEMA7A SEMA7A SMAD3 SMAD3 ALDH1A2 ALDH1A2 ACTC1 ACTC1 GSC GSC ZFP36L1 ZFP36L1 CR201_G0009767 CR201_G0009767 SIX4 SIX4 SIX1 SIX1 BMP4 BMP4 FGF9 FGF9 CR201_G0000883 CR201_G0000883 TBX3 TBX3 TBX5 TBX5 CORO1C CORO1C KITLG KITLG ALX1 ALX1 ENSPPYP00000005397 ENSPPYP00000005397 HMGA2 HMGA2 ERBB3 ERBB3 ACVRL1 ACVRL1 YAP1 YAP1 WNT11 WNT11 TAF10 TAF10 APLNR APLNR FGF19 FGF19 FGFR2 FGFR2 CR201_G0023542 CR201_G0023542 SEMA4G SEMA4G PAX2 PAX2 CYP26C1 CYP26C1 ACTA2 ACTA2 NODAL NODAL DLG5 DLG5 BMPR1A BMPR1A RET RET NRP1 NRP1 CPLANE2 CPLANE2 CDC42 CDC42 WNT4 WNT4 PHACTR4 PHACTR4 PEF1 PEF1 HEYL HEYL TGFBR3 TGFBR3 SEMA6C SEMA6C S100A4 S100A4 ADAM15 ADAM15 EFNA1 EFNA1 SEMA4A SEMA4A KLHL12 KLHL12 MDM4 MDM4 TGFB2 TGFB2 WNT3A WNT3A ACTA1 ACTA1 NUP133 NUP133
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SEMA4BSEMA4B isoform 4. (930 aa)
ROBO2ROBO2 isoform 6. (1384 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (442 aa)
WT1WT1 isoform 2. (320 aa)
OVOL2Ovo like zinc finger 2. (289 aa)
FOXH1FOXH1 isoform 1. (366 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1000 aa)
LOXL2Lysyl oxidase homolog 2; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys- 9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member o [...] (549 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
ENSPPYP00000023667annotation not available (104 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (158 aa)
NOLC1NOLC1 isoform 7. (726 aa)
RPS740S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
FLNAFLNA isoform 7. (2647 aa)
ZIC3Zic family member 3. (466 aa)
AMER1APC membrane recruitment protein 1. (1136 aa)
OTUD5OTUD5 isoform 2. (533 aa)
AMELXAMELY isoform 1. (205 aa)
NOTCH1NOTCH1 isoform 1. (2107 aa)
CR201_G0027392OLFM1 isoform 6. (357 aa)
ENGENG isoform 3. (668 aa)
AKNAAKNA isoform 1. (1357 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
SEMA4DSEMA4D isoform 10; Belongs to the semaphorin family. (862 aa)
BNC2BNC2 isoform 1. (1099 aa)
SCXSCX isoform 1. (200 aa)
ENSPPYP00000021204annotation not available (300 aa)
HAS2HAS2 isoform 1. (511 aa)
EXT1Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). (746 aa)
ZFPM2ZFPM2 isoform 1. (1152 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
CR201_G0033322SFRP1 isoform 1. (260 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
NRG1NRG1 isoform 10. (692 aa)
GATA4GATA binding protein 4. (442 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (460 aa)
NOS3NOS3 isoform 2. (833 aa)
EXOC4EXOC4 isoform 2. (974 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
SEMA3CSemaphorin-3C; Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity). (754 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
SEMA3ESEMA3E isoform 1; Belongs to the semaphorin family. (504 aa)
SEMA3ASEMA3A isoform 1; Belongs to the semaphorin family. (771 aa)
SEMA3DSEMA3D isoform 1; Belongs to the semaphorin family. (777 aa)
TWIST1Twist family bHLH transcription factor 1. (203 aa)
HOXA5HOXA5 isoform 1. (381 aa)
TBX20TBX20 isoform 1. (447 aa)
RADILRADIL isoform 3. (1062 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
TCF21Transcription factor 21. (179 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
ENSPPYP00000018739annotation not available (186 aa)
BMP5BMP5 isoform 1. (453 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1030 aa)
CUL7Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin- protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] (1723 aa)
NOTCH4NOTCH4 isoform 1. (2000 aa)
RBM24RNA binding motif protein 24. (236 aa)
EDN1EDN1 isoform 1. (212 aa)
FOXC1FOXC1 isoform 1. (332 aa)
FOXF2FOXF2 isoform 1. (184 aa)
HNRNPABHNRNPAB isoform 1. (261 aa)
CR201_G0004819NKX2-5 isoform 1. (210 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
ANXA6Annexin. (660 aa)
TCOF1TCOF1 isoform 1. (1489 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
SEMA6ASEMA6A isoform 1; Belongs to the semaphorin family. (1030 aa)
FBXL17FBXL17 isoform 1. (751 aa)
FAM172AFamily with sequence similarity 172 member A. (416 aa)
MEF2CMyocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (441 aa)
ISL1ISL1 isoform 1. (349 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
GDNFGDNF isoform 6. (185 aa)
BASP1Brain abundant membrane attached signal protein 1. (227 aa)
SEMA5ASEMA5A isoform 1. (1044 aa)
PDCD6Programmed cell death protein 6 isoform X1. (191 aa)
HAND2HAND2 isoform 1. (217 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
EDNRAEDNRA isoform 1; Belongs to the G-protein coupled receptor 1 family. (425 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
PITX2Homeobox protein. (317 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
PKD2PKD2 isoform 1. (968 aa)
CR201_G0036073PHOX2B isoform 1. (269 aa)
TAPT1TAPT1 isoform 2. (532 aa)
ENSPPYP00000016309annotation not available (193 aa)
MSX1MSX1 isoform 1. (261 aa)
HES1HES1 isoform 1. (198 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
EOMESEOMES isoform 3. (704 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
CTNNB1CTNNB1 isoform 2. (781 aa)
SEMA3FSEMA3F isoform 4; Belongs to the semaphorin family. (755 aa)
SEMA3BSEMA3B isoform 6; Belongs to the semaphorin family. (690 aa)
SEMA3GSEMA3G isoform 1; Belongs to the semaphorin family. (878 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (473 aa)
TASORFAM208A isoform 4. (1354 aa)
CR201_G0046097KBTBD8 isoform 2. (415 aa)
CRELD1CRELD1 isoform 1. (481 aa)
ROBO1ROBO1 isoform 6. (1612 aa)
DPPA4Developmental pluripotency associated 4. (303 aa)
POGLUT1Protein O-glucosyltransferase 1. (392 aa)
GSK3BGSK3B isoform 2; Belongs to the protein kinase superfamily. (380 aa)
SEMA5BSEMA5B isoform 1. (1091 aa)
GBX2GBX2 isoform 1. (173 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (422 aa)
FN1FN1 isoform 4. (2445 aa)
ERBB4Receptor protein-tyrosine kinase. (1284 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
STAT1Signal transducer and activator of transcription. (766 aa)
FRZBSecreted frizzled-related protein 3; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development (By similarity). (325 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (733 aa)
SEMA4CSEMA4C isoform 1; Belongs to the semaphorin family. (746 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
OSR1OSR1 isoform 1. (265 aa)
SIX2SIX homeobox 2. (291 aa)
RTN4Reticulon. (1192 aa)
ACTG2ACTG2 isoform 3. (378 aa)
LOXL3LOXL3 isoform 4. (668 aa)
CR201_G0002974SEMA4F isoform 2; Belongs to the semaphorin family. (585 aa)
POLR1BDNA-directed RNA polymerase I subunit RPA2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). (1135 aa)
ENSPPYP00000013398annotation not available (195 aa)
DDX17DDX17 isoform 4; Belongs to the DEAD box helicase family. (650 aa)
SOX10SOX10 isoform 2. (436 aa)
TBX1TBX1 isoform 2. (213 aa)
GATA5GATA binding protein 5. (397 aa)
CR201_G0055991LAMA5 isoform 1. (2926 aa)
EDN3EDN3 isoform 1. (229 aa)
BMP7Bone morphogenetic protein 7. (365 aa)
ZFP64ZFP64 isoform 2. (629 aa)
SNAI1SNAI1 isoform 1. (263 aa)
FAM83DFAM83D isoform 1. (613 aa)
ACTL10ACTL10 isoform 1; Belongs to the actin family. (245 aa)
PAX1PAX1 isoform 1. (447 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
TRIM28TRIM28 isoform 3. (528 aa)
TEAD2TEA domain transcription factor 2. (447 aa)
DACT3DACT3 isoform 2. (516 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
DLL3Delta like canonical Notch ligand 3. (587 aa)
DAND5DAN domain BMP antagonist family member 5. (189 aa)
NRTNNRTN isoform 1. (197 aa)
SEMA6BSEMA6B isoform 1; Belongs to the semaphorin family. (876 aa)
AMHAMH isoform 1. (561 aa)
BCL2BCL2 isoform 1. (238 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SMAD2Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] (467 aa)
CDH2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic s [...] (906 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1299 aa)
ENSPPYP00000010097annotation not available (194 aa)
TBX2TBX2 isoform 1. (588 aa)
SOX9SRY-box transcription factor 9. (509 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] (614 aa)
MEOX1Mesenchyme homeobox 1. (254 aa)
TMEM100Transmembrane protein 100. (134 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
RFLNBRFLNB isoform 1. (152 aa)
FOXF1FOXF1 isoform 1. (380 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa)
SOX8SRY-box transcription factor 8. (446 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (269 aa)
SEMA7ASEMA7A isoform 1; Belongs to the semaphorin family. (664 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
ACTC1Actin alpha cardiac muscle 1. (377 aa)
GSCGoosecoid homeobox. (257 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
CR201_G0009767HIF1A isoform 5. (735 aa)
SIX4SIX4 isoform 1. (698 aa)
SIX1SIX homeobox 1. (284 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CR201_G0000883HNF1A isoform 7. (347 aa)
TBX3T-box transcription factor 3. (743 aa)
TBX5T-box transcription factor 5. (518 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (434 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (262 aa)
ALX1ALX homeobox 1. (326 aa)
ENSPPYP00000005397annotation not available (67 aa)
HMGA2High mobility group AT-hook 2. (147 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation. (1342 aa)
ACVRL1Serine/threonine-protein kinase receptor R3; Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well (By similarity). (503 aa)
YAP1YAP1 isoform 2. (326 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
APLNRAPLNR isoform 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGFR2Fibroblast growth factor receptor. (656 aa)
CR201_G0023542Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (166 aa)
SEMA4GSEMA4G isoform 7; Belongs to the semaphorin family. (811 aa)
PAX2PAX2 isoform 3. (388 aa)
CYP26C1CYP26C1 isoform 2; Belongs to the cytochrome P450 family. (518 aa)
ACTA2ACTA2 isoform 5. (399 aa)
NODALNodal growth differentiation factor. (347 aa)
DLG5DLG5 isoform 1; Belongs to the MAGUK family. (1809 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1116 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
CPLANE2Ciliogenesis and planar polarity effector 2. (258 aa)
CDC42Cell division cycle 42. (191 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
PHACTR4Phosphatase and actin regulator 4; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to [...] (687 aa)
PEF1Penta-EF-hand domain containing 1. (284 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
TGFBR3TGFBR3 isoform 1. (859 aa)
SEMA6CSEMA6C isoform 1; Belongs to the semaphorin family. (932 aa)
S100A4Protein S100; Belongs to the S-100 family. (101 aa)
ADAM15ADAM15 isoform 14. (750 aa)
EFNA1EFNA1 isoform 1; Belongs to the ephrin family. (205 aa)
SEMA4ASEMA4A isoform 10; Belongs to the semaphorin family. (709 aa)
KLHL12KLHL12 isoform 2. (567 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (385 aa)
ACTA1Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
NUP133NUP133 isoform 1. (1154 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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