(51 nodes) Regulation of morphogenesis of a branching structure network (Pongo abelii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	BMP4	Bone morphogenetic protein 4. (408 aa)
	LRRK2	LRRK2 isoform 3. (1560 aa)
	AGTR2	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	DKFZp468G2216	AR isoform 8. (388 aa)
	MAGED1	MAGE family member D1. (778 aa)
	ABL1	Tyrosine-protein kinase. (948 aa)
	CR201_G0027499	ABL1 isoform 3. (48 aa)
	SULF1	Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (868 aa)
	SNAI2	Snail family transcriptional repressor 2. (268 aa)
	CR201_G0033322	SFRP1 isoform 1. (260 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (460 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
	WNT2	Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
	CR201_G0040964	PDGFA isoform 2; Belongs to the PDGF/VEGF growth factor family. (135 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
	FKBPL	FKBP prolyl isomerase like. (349 aa)
	TNF	Tumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family. (233 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	GDNF	GDNF isoform 6. (185 aa)
	MAP3K13	Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB- containing complex that phosphorylates inhibitors of NF-kappa-B (By similarity). (965 aa)
	CR201_G0007803	SHOX2 isoform 5. (151 aa)
	CTNNB1	CTNNB1 isoform 2. (781 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (473 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa)
	HOXD13	HOXD13 isoform 1. (343 aa)
	SIX2	SIX homeobox 2. (291 aa)
	RTN4	Reticulon. (1192 aa)
	BCL11A	BAF chromatin remodeling complex subunit BCL11A. (773 aa)
	LOC100438930	MDK isoform 6. (143 aa)
	BMP7	Bone morphogenetic protein 7. (365 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	SIRT6	SIRT6 isoform 1. (355 aa)
	HOXB7	HOXB7 isoform 2. (217 aa)
	SOX9	SRY-box transcription factor 9. (509 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	LHX1	LHX1 isoform 1. (406 aa)
	SOX8	SRY-box transcription factor 8. (446 aa)
	GALK2	N-acetylgalactosamine kinase; Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations (By similarity). (543 aa)
	GREM1	Gremlin. (184 aa)
	BTBD7	BTBD7 isoform 3. (1134 aa)
	PGF	PGF isoform 1; Belongs to the PDGF/VEGF growth factor family. (161 aa)
	SIX4	SIX4 isoform 1. (698 aa)
	SIX1	SIX homeobox 1. (284 aa)
	NTN4	Netrin-4; May play an important role in neural, kidney and vascular development. (628 aa)
	LGR4	LGR4 isoform 1. (947 aa)
	FGFR2	Fibroblast growth factor receptor. (656 aa)
	PAX2	PAX2 isoform 3. (388 aa)
	TACSTD2	Tumor associated calcium signal transducer 2. (323 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
	AGT	AGT isoform 1; Belongs to the serpin family. (485 aa)

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	CTNNB1	ENSPPYP00000022265	ENSPPYP00000015644	Tyrosine-protein kinase.	CTNNB1 isoform 2.	0.804
ABL1	ESR1	ENSPPYP00000022265	ENSPPYP00000019159	Tyrosine-protein kinase.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.412
ABL1	SMO	ENSPPYP00000022265	ENSPPYP00000020186	Tyrosine-protein kinase.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.498
AGT	AGTR2	ENSPPYP00000000122	ENSPPYP00000023121	AGT isoform 1; Belongs to the serpin family.	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family.	0.999
AGT	FGF10	ENSPPYP00000000122	ENSPPYP00000017257	AGT isoform 1; Belongs to the serpin family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.464
AGT	HGF	ENSPPYP00000000122	ENSPPYP00000020015	AGT isoform 1; Belongs to the serpin family.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.418
AGT	TGFB1	ENSPPYP00000000122	ENSPPYP00000011208	AGT isoform 1; Belongs to the serpin family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.587
AGT	TNF	ENSPPYP00000000122	ENSPPYP00000018379	AGT isoform 1; Belongs to the serpin family.	Tumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family.	0.675
AGTR2	AGT	ENSPPYP00000023121	ENSPPYP00000000122	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family.	AGT isoform 1; Belongs to the serpin family.	0.999
BMP4	BMP7	ENSPPYP00000006620	ENSPPYP00000012465	Bone morphogenetic protein 4.	Bone morphogenetic protein 7.	0.856
BMP4	CR201_G0040964	ENSPPYP00000006620	ENSPPYP00000019376	Bone morphogenetic protein 4.	PDGFA isoform 2; Belongs to the PDGF/VEGF growth factor family.	0.479
BMP4	CTNNB1	ENSPPYP00000006620	ENSPPYP00000015644	Bone morphogenetic protein 4.	CTNNB1 isoform 2.	0.598
BMP4	FGF10	ENSPPYP00000006620	ENSPPYP00000017257	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.682
BMP4	FGFR2	ENSPPYP00000006620	ENSPPYP00000003165	Bone morphogenetic protein 4.	Fibroblast growth factor receptor.	0.528
BMP4	GDNF	ENSPPYP00000006620	ENSPPYP00000017215	Bone morphogenetic protein 4.	GDNF isoform 6.	0.546
BMP4	GREM1	ENSPPYP00000006620	ENSPPYP00000007140	Bone morphogenetic protein 4.	Gremlin.	0.970
BMP4	NOG	ENSPPYP00000006620	ENSPPYP00000009271	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.998
BMP4	PAX2	ENSPPYP00000006620	ENSPPYP00000002985	Bone morphogenetic protein 4.	PAX2 isoform 3.	0.424
BMP4	SHH	ENSPPYP00000006620	ENSPPYP00000020423	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.768
BMP4	SOX9	ENSPPYP00000006620	ENSPPYP00000009638	Bone morphogenetic protein 4.	SRY-box transcription factor 9.	0.515