STRINGSTRING
MMP21 MMP21 VEGFB VEGFB APLNR APLNR DYNC2H1 DYNC2H1 ENSPPYP00000004367 ENSPPYP00000004367 CR201_G0025506 CR201_G0025506 PRICKLE1 PRICKLE1 ARID2 ARID2 TBX5 TBX5 BMP4 BMP4 SMAD6 SMAD6 MESP1 MESP1 AP2B1 AP2B1 ZBTB14 ZBTB14 GATA6 GATA6 TBX1 TBX1 DCTN5 DCTN5 MYOCD MYOCD SEC24B SEC24B LRP2 LRP2 GPC3 GPC3 NOTCH1 NOTCH1 CNTRL CNTRL TGFBR1 TGFBR1 HEY2 HEY2 PRDM1 PRDM1 ENSPPYP00000018739 ENSPPYP00000018739 SRF SRF PTK7 PTK7 SGCD SGCD NDST1 NDST1 PDGFRB PDGFRB ADAMTS6 ADAMTS6 CR201_G0011909 CR201_G0011909 HAND2 HAND2 SETD2 SETD2 PLXND1 PLXND1 TGFBR3 TGFBR3 NRP1 NRP1 SUFU SUFU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MMP21MMP21 isoform 1. (569 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
APLNRAPLNR isoform 1; Belongs to the G-protein coupled receptor 1 family. (380 aa)
DYNC2H1DYNC2H1 isoform 2. (987 aa)
ENSPPYP00000004367annotation not available (644 aa)
CR201_G0025506DYNC2H1 isoform 3. (1794 aa)
PRICKLE1Prickle planar cell polarity protein 1. (831 aa)
ARID2AT-rich interaction domain 2. (1836 aa)
TBX5T-box transcription factor 5. (518 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SMAD6Mothers against decapentaplegic homolog. (404 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (269 aa)
AP2B1AP complex subunit beta. (951 aa)
ZBTB14Zinc finger and BTB domain containing 14. (449 aa)
GATA6GATA6 isoform 1. (580 aa)
TBX1TBX1 isoform 2. (213 aa)
DCTN5Dynactin subunit 5; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily. (182 aa)
MYOCDMYOCD isoform 1. (986 aa)
SEC24BSEC24B isoform 3. (1137 aa)
LRP2LRP2 isoform 1. (4512 aa)
GPC3GPC3 isoform 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa)
NOTCH1NOTCH1 isoform 1. (2107 aa)
CNTRLCNTRL isoform 3. (2183 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
PRDM1PR/SET domain 1. (825 aa)
ENSPPYP00000018739annotation not available (186 aa)
SRFSerum response factor. (508 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1030 aa)
SGCDSarcoglycan delta. (289 aa)
NDST1N-deacetylase and N-sulfotransferase 1. (882 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
ADAMTS6ADAMTS6 isoform 1. (1087 aa)
CR201_G0011909C5orf42 isoform 1. (2624 aa)
HAND2HAND2 isoform 1. (217 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2563 aa)
PLXND1PLXND1 isoform 1. (1818 aa)
TGFBR3TGFBR3 isoform 1. (859 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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