STRINGSTRING
SCX SCX CCN1 CCN1 LOXL2 LOXL2 GDF2 GDF2 SOX6 SOX6 ZBTB16 ZBTB16 SOX5 SOX5 ZNF219 ZNF219 BMP4 BMP4 SMAD3 SMAD3 SOX9 SOX9 SMAD7 SMAD7 GDF5 GDF5 LOC100438930 LOC100438930 LOXL3 LOXL3 BMP10 BMP10 PKDCC PKDCC CR201_G0017164 CR201_G0017164 BMPR2 BMPR2 WNT5A WNT5A TAPT1 TAPT1 BMPR1B BMPR1B ENSPPYP00000016868 ENSPPYP00000016868 SMAD1 SMAD1 FGF18 FGF18 BMP2 BMP2 BMP6 BMP6 RUNX2 RUNX2 POR POR GLI3 GLI3 HOXA11 HOXA11 GDF6 GDF6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCXSCX isoform 1. (200 aa)
CCN1Cellular communication network factor 1. (381 aa)
LOXL2Lysyl oxidase homolog 2; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys- 9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member o [...] (549 aa)
GDF2Growth differentiation factor 2. (429 aa)
SOX6Transcription factor SOX-6; Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation (By similarity). (855 aa)
ZBTB16ZBTB16 isoform 1. (605 aa)
SOX5SOX5 isoform 3. (715 aa)
ZNF219Zinc finger protein 219. (720 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SOX9SRY-box transcription factor 9. (509 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
GDF5Growth differentiation factor 5. (501 aa)
LOC100438930MDK isoform 6. (143 aa)
LOXL3LOXL3 isoform 4. (668 aa)
BMP10BMP10 isoform 1. (424 aa)
PKDCCPKDCC isoform 1. (281 aa)
CR201_G0017164HOXD11 isoform 2. (143 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (473 aa)
TAPT1TAPT1 isoform 2. (532 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (492 aa)
ENSPPYP00000016868annotation not available (85 aa)
SMAD1Mothers against decapentaplegic homolog. (73 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
BMP6BMP6 isoform 1. (510 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (589 aa)
PORNADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (466 aa)
GLI3GLI3 isoform 3. (1580 aa)
HOXA11HOXA11 isoform 2. (315 aa)
GDF6Growth differentiation factor 6. (455 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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