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| | RNF34 | E3 ubiquitin-protein ligase RNF34; E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway. Negatively regulates p5 [...] (373 aa) |
| | HECTD1 | HECT domain E3 ubiquitin protein ligase 1. (2610 aa) |
| | RNF31 | T0114761 isoform 1. (1053 aa) |
| | CCNB1IP1 | CCNB1IP1 isoform 10. (297 aa) |
| | SIAH3 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (269 aa) |
| | NHLRC3 | NHL repeat-containing protein 3. (347 aa) |
| | RNF6 | RNF6 isoform 2. (685 aa) |
| | RNF10 | RNF10 isoform 1. (725 aa) |
| | WSB2 | WD repeat and SOCS box containing 2. (404 aa) |
| | RNFT2 | RING finger and transmembrane domain-containing protein 2. (436 aa) |
| | DTX1 | DTX1 isoform 1. (599 aa) |
| | BRAP | BRAP isoform 1. (528 aa) |
| | UBE3B | UBE3B isoform 1. (1068 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (496 aa) |
| | RNF41 | E3 ubiquitin-protein ligase NRDP1; Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progeni [...] (317 aa) |
| | ENSPPYP00000004676 | annotation not available (311 aa) |
| | ENSPPYP00000004668 | annotation not available (375 aa) |
| | LOC100455440 | TRIM64C isoform 1. (450 aa) |
| | CR201_G0034040 | TRIM49D1 isoform 2. (206 aa) |
| | RNF26 | RNF26 isoform 1. (433 aa) |
| | CBL | Cbl proto-oncogene. (905 aa) |
| | VPS11 | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (941 aa) |
| | UBE4A | Ubiquitin conjugation factor E4 A; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. (1072 aa) |
| | BIRC2 | Baculoviral IAP repeat containing 2. (597 aa) |
| | LOC100456169 | TRIM49D2 isoform 1. (459 aa) |
| | LOC100455080 | TRIM49 isoform 1. (452 aa) |
| | ENSPPYP00000004302 | annotation not available (444 aa) |
| | RNF121 | Ring finger protein 121. (327 aa) |
| | TRIM21 | TRIM21 isoform 1. (368 aa) |
| | TRIM68 | TRIM68 isoform 1. (344 aa) |
| | TRIM34 | TRIM34 isoform 1. (842 aa) |
| | TRIM22 | TRIM22 isoform 3. (498 aa) |
| | TRIM3 | TRIM3 isoform 1. (712 aa) |
| | SERGEF | SERGEF isoform 5. (457 aa) |
| | FANCF | FA complementation group F. (374 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (604 aa) |
| | RAG2 | Recombination activating 2. (527 aa) |
| | DTX4 | Deltex E3 ubiquitin ligase 4. (619 aa) |
| | PRPF19 | PRPF19 isoform 1. (523 aa) |
| | SYVN1 | SYVN1 isoform 3. (616 aa) |
| | PELI3 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (445 aa) |
| | CR201_G0012618 | C10orf90 isoform 4. (555 aa) |
| | BTRC | BTRC isoform 2. (605 aa) |
| | MARCHF5 | Membrane associated ring-CH-type finger 5. (278 aa) |
| | UBE2D1 | Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4. (1057 aa) |
| | MARCHF8 | MARCH8 isoform 2. (291 aa) |
| | UBE4B | UBE4B isoform 1. (1106 aa) |
| | FBXO44 | F-box protein 44. (224 aa) |
| | FBXO6 | F-box protein 6. (293 aa) |
| | UBR4 | UBR4 isoform 1. (5118 aa) |
| | RNF186 | RNF186 isoform 1. (227 aa) |
| | MUL1 | Mitochondrial E3 ubiquitin protein ligase 1. (352 aa) |
| | CDC42 | Cell division cycle 42. (191 aa) |
| | PNRC2 | Proline rich nuclear receptor coactivator 2. (139 aa) |
| | TRIM63 | TRIM63 isoform 2. (353 aa) |
| | RNF19B | RBR-type E3 ubiquitin transferase. (629 aa) |
| | CR201_G0015745 | TRIM62 isoform 3. (352 aa) |
| | RNF220 | RNF220 isoform 1. (540 aa) |
| | RNF11 | Ring finger protein 11. (154 aa) |
| | RNF115 | Ring finger protein 115. (304 aa) |
| | DCST1 | DCST1 isoform 1. (654 aa) |
| | RC3H1 | RC3H1 isoform 1. (1094 aa) |
| | COP1 | COP1 E3 ubiquitin ligase. (731 aa) |
| | RNF2 | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, i [...] (336 aa) |
| | TRIM11 | TRIM11 isoform 1. (436 aa) |
| | CR201_G0030864 | TRIM17 isoform 7. (280 aa) |
| | CR201_G0030856 | RNF187 isoform 1. (49 aa) |
| | TRIM58 | TRIM58 isoform 1. (486 aa) |
| | IRF2BPL | IRF2BPL isoform 1. (481 aa) |
| | ENSPPYP00000024529 | E3 ubiquitin-protein ligase HERC2-like. (150 aa) |
| | RNF167 | Ring finger protein 167. (375 aa) |
| | NEURL1 | Neuralized E3 ubiquitin protein ligase 1. (661 aa) |
| | ZNRF2 | E3 ubiquitin-protein ligase ZNRF1/2. (240 aa) |
| | TRIM27 | Tripartite motif containing 27. (513 aa) |
| | RNF130 | RNF130 isoform 4. (420 aa) |
| | MYCBP2 | MYCBP2 isoform 1. (3875 aa) |
| | ENSPPYP00000024133 | E3 ubiquitin-protein ligase HERC2-like. (155 aa) |
| | ANKIB1 | RBR-type E3 ubiquitin transferase. (1089 aa) |
| | ENSPPYP00000024029 | annotation not available (269 aa) |
| | ENSPPYP00000023951 | annotation not available (319 aa) |
| | MEX3C | MEX3C isoform 1. (258 aa) |
| | RFFL | T0183779 isoform 1. (369 aa) |
| | PPP1R11 | PPP1R11 isoform 1. (104 aa) |
| | RNF149 | RNF149 isoform 1. (414 aa) |
| | HECW2 | HECW2 isoform 3. (1572 aa) |
| | TRAF3IP2 | TRAF3 interacting protein 2. (572 aa) |
| | XIAP | XIAP isoform 2. (513 aa) |
| | RNF113A | Ring finger protein 113A. (343 aa) |
| | LONRF3 | LONRF3 isoform 3. (811 aa) |
| | RNF128 | E3 ubiquitin-protein ligase RNF128; E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down- regulation of these cytoslele [...] (428 aa) |
| | RLIM | Ring finger protein, LIM domain interacting. (624 aa) |
| | ASB12 | Ankyrin repeat and SOCS box containing 12. (318 aa) |
| | HUWE1 | HUWE1 isoform 1. (4373 aa) |
| | CR201_G0022864 | MKRN1 isoform 4. (480 aa) |
| | CBLL2 | Cbl proto-oncogene like 2. (425 aa) |
| | CR201_G0055502 | TRIM48 isoform 1. (209 aa) |
| | CR201_G0055498 | TRIM64B isoform 1. (440 aa) |
| | LOC100445599 | TRIM49B isoform 1. (452 aa) |
| | TRIM52 | TRIM52 isoform 2. (319 aa) |
| | TRIM41 | TRIM41 isoform 2. (517 aa) |
| | TRIM7 | TRIM7 isoform 2. (357 aa) |
| | ENSPPYP00000022318 | annotation not available (452 aa) |
| | CR201_G0001999 | NFX1 isoform 5. (467 aa) |
| | RNF208 | Ring finger protein 208. (261 aa) |
| | MED27 | Mediator of RNA polymerase II transcription subunit 27; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (311 aa) |
| | LRSAM1 | LRSAM1 isoform 1. (689 aa) |
| | RC3H2 | RC3H2 isoform 1. (1143 aa) |
| | TRIM32 | Tripartite motif containing 32. (653 aa) |
| | BSPRY | B-box and SPRY domain containing. (400 aa) |
| | RNF20 | E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa) |
| | TRIM14 | Tripartite motif containing 14. (442 aa) |
| | UHRF2 | Ubiquitin like with PHD and ring finger domains 2. (802 aa) |
| | NFX1 | NFX1 isoform 1. (697 aa) |
| | RNF38 | Ring finger protein 38. (432 aa) |
| | MED30 | Mediator complex subunit 30. (178 aa) |
| | UBR5 | UBR5 isoform 1. (2695 aa) |
| | WWP1 | E3 ubiquitin-protein ligase. (773 aa) |
| | TRIM55 | TRIM55 isoform 1. (544 aa) |
| | RNF170 | RNF170 isoform 3. (227 aa) |
| | RNF122 | Ring finger protein 122. (155 aa) |
| | LONRF1 | LONRF1 isoform 1. (746 aa) |
| | TRIM73 | LOW QUALITY PROTEIN: tripartite motif-containing protein 73. (250 aa) |
| | ENSPPYP00000020474 | annotation not available (97 aa) |
| | UBE3C | UBE3C isoform 2. (1080 aa) |
| | MKRN1 | Makorin ring finger protein 1. (418 aa) |
| | TRIM24 | TRIM24 isoform 1. (1050 aa) |
| | CBLL1 | CBLL1 isoform 1. (402 aa) |
| | ASB4 | Ankyrin repeat and SOCS box containing 4. (426 aa) |
| | HECW1 | HECW1 isoform 1. (1608 aa) |
| | RABGEF1 | RABGEF1 isoform 2. (544 aa) |
| | TRIM50 | TRIM73 isoform 3. (487 aa) |
| | DTX2 | Deltex E3 ubiquitin ligase 2. (622 aa) |
| | TRIM56 | TRIM56 isoform 1. (755 aa) |
| | TRIM4 | Tripartite motif containing 4. (474 aa) |
| | SMURF1 | E3 ubiquitin-protein ligase. (838 aa) |
| | RNF216 | Ring finger protein 216. (866 aa) |
| | RING1 | Ring finger protein 1. (406 aa) |
| | TRIM26 | TRIM26 isoform 1. (539 aa) |
| | TRIM15 | Tripartite motif containing 15. (465 aa) |
| | TRIM40 | Tripartite motif containing 40. (258 aa) |
| | TRIM31 | TRIM31 isoform 1. (427 aa) |
| | RNF39 | RNF39 isoform 1. (419 aa) |
| | CR201_G0036895 | PRKN isoform 8. (335 aa) |
| | SHPRH | SNF2 histone linker PHD RING helicase. (1683 aa) |
| | FBXO30 | FBXO30 isoform 1. (708 aa) |
| | RNF146 | E3 ubiquitin-protein ligase RNF146; E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CA [...] (355 aa) |
| | CR201_G0047659 | RBR-type E3 ubiquitin transferase. (219 aa) |
| | HACE1 | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1. (909 aa) |
| | UBR2 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1728 aa) |
| | RNF5 | Ring finger protein 5. (180 aa) |
| | TRIM39 | Tripartite motif-containing protein 39. (488 aa) |
| | TRIM38 | Tripartite motif containing 38. (465 aa) |
| | RNF144B | RBR-type E3 ubiquitin transferase. (303 aa) |
| | NHLRC1 | NHL repeat containing E3 ubiquitin protein ligase 1. (395 aa) |
| | MYLIP | Myosin regulatory light chain interacting protein. (445 aa) |
| | CR201_G0051583 | RNF44 isoform 1. (291 aa) |
| | RMND5B | RMND5B isoform 1. (407 aa) |
| | N4BP3 | NEDD4 binding protein 3. (544 aa) |
| | NEURL1B | Neuralized E3 ubiquitin protein ligase 1B. (555 aa) |
| | FBXW11 | FBXW11 isoform 1. (489 aa) |
| | RNF145 | RNF145 isoform 7. (663 aa) |
| | SH3RF2 | SH3 domain containing ring finger 2. (729 aa) |
| | RNF14 | RBR-type E3 ubiquitin transferase. (474 aa) |
| | JADE2 | JADE2 isoform 7. (919 aa) |
| | ENSPPYP00000017434 | Mediator of RNA polymerase II transcription subunit 27. (311 aa) |
| | RNF180 | E3 ubiquitin-protein ligase RNF180; E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2. (579 aa) |
| | FBXO4 | FBXO4 isoform 2. (387 aa) |
| | MARCHF6 | E3 ubiquitin-protein ligase MARCHF6; E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation. Promotes ubiquitination of DIO2, leading to its degradation. Promotes ubiquitination of SQLE, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. (910 aa) |
| | CR201_G0045132 | TRIML1 isoform 1. (373 aa) |
| | CR201_G0045128 | TRIML2 isoform 1. (346 aa) |
| | SH3RF1 | E3 ubiquitin-protein ligase SH3RF1; Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin- dependent and clathrin-independent endocytosis. Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pa [...] (888 aa) |
| | ENSPPYP00000016962 | annotation not available (353 aa) |
| | TRIM75P | TRIM75P isoform 1. (481 aa) |
| | TRIM61 | TRIM61 isoform 1. (177 aa) |
| | ENSPPYP00000016953 | annotation not available (199 aa) |
| | MARCHF1 | MARCH1 isoform 2. (542 aa) |
| | RNF175 | RNF175 isoform 1. (329 aa) |
| | TRIM2 | Tripartite motif containing 2. (744 aa) |
| | RNF150 | RNF150 isoform 4. (439 aa) |
| | HERC5 | HERC5 isoform 1. (433 aa) |
| | HERC6 | HERC6 isoform 3. (875 aa) |
| | RCHY1 | Ring finger and CHY zinc finger domain containing 1. (261 aa) |
| | UBE2K | Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa) |
| | TMEM129 | Transmembrane protein 129. (362 aa) |
| | MAEA | E3 ubiquitin-protein transferase MAEA; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin- protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast enucleat [...] (393 aa) |
| | SIAH2 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa) |
| | RNF13 | E3 ubiquitin-protein ligase RNF13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. (381 aa) |
| | HLTF | HLTF isoform 1. (1063 aa) |
| | RNF7 | Ring finger protein 7. (113 aa) |
| | MSL2 | MSL2 isoform 4. (286 aa) |
| | TRIM71 | TRIM71 isoform 1. (867 aa) |
| | ARIH2 | RBR-type E3 ubiquitin transferase. (456 aa) |
| | TRAIP | TRAIP isoform 1. (470 aa) |
| | PDZRN3 | PDZ domain containing ring finger 3. (1066 aa) |
| | RAD18 | RAD18 isoform 2. (495 aa) |
| | CBLB | Cbl proto-oncogene B. (982 aa) |
| | DZIP3 | DZIP3 isoform 1. (1176 aa) |
| | FBXO40 | F-box protein 40. (709 aa) |
| | DTX3L | DTX3L isoform 1. (708 aa) |
| | MKRN2 | Makorin ring finger protein 2. (416 aa) |
| | ZSWIM2 | ZSWIM2 isoform 2. (593 aa) |
| | ASB1 | Ankyrin repeat and SOCS box containing 1. (335 aa) |
| | TRIP12 | TRIP12 isoform 4. (2039 aa) |
| | CUL3 | CUL3 isoform 1; Belongs to the cullin family. (768 aa) |
| | RNF25 | RNF25 isoform 1. (459 aa) |
| | UBR3 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (668 aa) |
| | ENSPPYP00000014209 | annotation not available (442 aa) |
| | CR201_G0056149 | TRIM43 isoform 1. (446 aa) |
| | RNF144A | RBR-type E3 ubiquitin transferase. (292 aa) |
| | FANCL | FA complementation group L. (375 aa) |
| | PELI1 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa) |
| | KCMF1 | KCMF1 isoform 1. (330 aa) |
| | RNF181 | Ring finger protein 181. (153 aa) |
| | RNF103 | Charged multivesicular body protein 3. (685 aa) |
| | RMND5A | Required for meiotic nuclear division 5 homolog A. (391 aa) |
| | CR201_G0043010 | SH3RF3 isoform 1. (650 aa) |
| | LONRF2 | LONRF2 isoform 1. (754 aa) |
| | TRIM9 | TRIM9 isoform 1. (807 aa) |
| | PELI2 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (420 aa) |
| | AREL1 | AREL1 isoform 1. (823 aa) |
| | UBR7 | Putative E3 ubiquitin-protein ligase UBR7. (331 aa) |
| | MKRN3 | Makorin ring finger protein 3. (507 aa) |
| | UBE3A | Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (849 aa) |
| | EIF2AK4 | EIF2AK4 isoform 2. (1573 aa) |
| | VPS18 | VPS18 core subunit of CORVET and HOPS complexes. (973 aa) |
| | UBR1 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1749 aa) |
| | TRIM69 | Tripartite motif containing 69. (500 aa) |
| | NEDD4 | E3 ubiquitin-protein ligase. (937 aa) |
| | RNF111 | E3 ubiquitin-protein ligase Arkadia; E3 ubiquitin-protein ligase (By similarity). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (By similarity). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by med [...] (984 aa) |
| | FBXL22 | FBXL22 isoform 1. (234 aa) |
| | ARIH1 | RBR-type E3 ubiquitin transferase. (557 aa) |
| | STUB1 | STIP1 homology and U-box containing protein 1. (303 aa) |
| | RNF151 | RNF151 isoform 2. (244 aa) |
| | ZNF598 | ZNF598 isoform 1. (898 aa) |
| | MEFV | MEFV isoform 4. (780 aa) |
| | MGRN1 | MGRN1 isoform 2. (576 aa) |
| | BFAR | Bifunctional apoptosis regulator. (450 aa) |
| | RBBP6 | RBBP6 isoform 8. (1758 aa) |
| | NSMCE1 | Non-structural maintenance of chromosomes element 1 homolog; RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE [...] (269 aa) |
| | TRIM72 | Tripartite motif containing 72. (477 aa) |
| | SIAH1 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa) |
| | AMFR | AMFR isoform 1. (548 aa) |
| | WWP2 | E3 ubiquitin-protein ligase. (874 aa) |
| | RFWD3 | RFWD3 isoform 1. (774 aa) |
| | ZNRF1 | Zinc and ring finger 1. (227 aa) |
| | RNF166 | RNF166 isoform 1. (215 aa) |
| | MED11 | Mediator of RNA polymerase II transcription subunit 11; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (117 aa) |
| | NEURL4 | Neuralized E3 ubiquitin protein ligase 4. (1562 aa) |
| | CR201_G0048045 | T0169084 isoform 2. (97 aa) |
| | GID4 | GID complex subunit 4 homolog. (300 aa) |
| | RNF112 | RNF112 isoform 1. (632 aa) |
| | WSB1 | WSB1 isoform 2. (421 aa) |
| | RNF135 | Ring finger protein 135. (432 aa) |
| | RNF43 | RNF43 isoform 2. (452 aa) |
| | ENSPPYP00000009265 | annotation not available (102 aa) |
| | TRIM25 | Tripartite motif containing 25. (630 aa) |
| | MED24 | MED24 isoform 12. (1054 aa) |
| | SMURF2 | E3 ubiquitin-protein ligase. (877 aa) |
| | RNF157 | RNF157 isoform 1. (619 aa) |
| | UBE2O | Ubiquitin conjugating enzyme E2 O. (1293 aa) |
| | RNF213 | RNF213 isoform 1. (4365 aa) |
| | RNFT1 | Ring finger protein, transmembrane 1. (434 aa) |
| | TRIM37 | TRIM37 isoform 1. (946 aa) |
| | ENSPPYP00000009926 | annotation not available (409 aa) |
| | RNF125 | RNF125 isoform 1. (196 aa) |
| | C18orf25 | Uncharacterized protein C18orf25 homolog. (343 aa) |
| | RNF165 | RNF165 isoform 2. (186 aa) |
| | NEDD4L | E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiq [...] (964 aa) |
| | RNF152 | Ring finger protein 152. (203 aa) |
| | FBXO15 | FBXO15 isoform 1. (434 aa) |
| | RNF126 | RNF126 isoform 1. (240 aa) |
| | UHRF1 | UHRF1 isoform 6. (802 aa) |
| | ZNRF4 | ZNRF4 isoform 1. (429 aa) |
| | CR201_G0051644 | MARCH2 isoform 3. (157 aa) |
| | CBLC | CBLC isoform 2. (430 aa) |
| | IRF2BP1 | Interferon regulatory factor 2 binding protein 1. (584 aa) |
| | NOSIP | Nitric oxide synthase-interacting protein; Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity; Belongs to the NOSIP family. (335 aa) |
| | RNF225 | RNF225 isoform 1. (314 aa) |
| | TRIM67 | TRIM67 isoform 3. (409 aa) |
| | RNF24 | RNF24 isoform 3. (148 aa) |
| | UBOX5 | UBOX5 isoform 2. (512 aa) |
| | ITCH | E3 ubiquitin-protein ligase. (849 aa) |
| | UBE2C | Ubiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) |
| | NEURL2 | NEURL2 isoform 1. (285 aa) |
| | RNF114 | RNF114 isoform 2. (240 aa) |
| | BIRC7 | Baculoviral IAP repeat containing 7. (280 aa) |
| | LTN1 | LTN1 isoform 1. (1700 aa) |
| | PPIL2 | PPIL2 isoform 1. (495 aa) |
| | ZNRF3 | ZNRF3 isoform 2. (881 aa) |
| | RNF215 | Ring finger protein 215. (377 aa) |
| | RNF185 | E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UB [...] (192 aa) |
| | RBX1 | RBX1 isoform 1. (108 aa) |
| | NEURL3 | NEURL3 isoform 1. (262 aa) |
