11 items (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	JAM2	Junctional adhesion molecule 2. (298 aa)
	MSN	MSN isoform 6. (577 aa)
	SEMA4D	SEMA4D isoform 10; Belongs to the semaphorin family. (862 aa)
	STK10	STK10 isoform 1. (968 aa)
	S100A9	Protein S100; Belongs to the S-100 family. (114 aa)
	S100A8	Protein S100; Belongs to the S-100 family. (93 aa)
	ZAP70	Tyrosine-protein kinase. (559 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
	RAC2	Rac family small GTPase 2. (192 aa)
	BMP7	Bone morphogenetic protein 7. (365 aa)
	CR201_G0011084	CD44 isoform 1. (351 aa)

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP7	CR201_G0011084	ENSPPYP00000012465	ENSPPYP00000003856	Bone morphogenetic protein 7.	CD44 isoform 1.	0.461
CR201_G0011084	BMP7	ENSPPYP00000003856	ENSPPYP00000012465	CD44 isoform 1.	Bone morphogenetic protein 7.	0.461
CR201_G0011084	IL1B	ENSPPYP00000003856	ENSPPYP00000013573	CD44 isoform 1.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.499
CR201_G0011084	MSN	ENSPPYP00000003856	ENSPPYP00000022855	CD44 isoform 1.	MSN isoform 6.	0.898
CR201_G0011084	S100A8	ENSPPYP00000003856	ENSPPYP00000000951	CD44 isoform 1.	Protein S100; Belongs to the S-100 family.	0.714
CR201_G0011084	S100A9	ENSPPYP00000003856	ENSPPYP00000000953	CD44 isoform 1.	Protein S100; Belongs to the S-100 family.	0.430
IL1B	CR201_G0011084	ENSPPYP00000013573	ENSPPYP00000003856	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	CD44 isoform 1.	0.499
IL1B	S100A8	ENSPPYP00000013573	ENSPPYP00000000951	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Protein S100; Belongs to the S-100 family.	0.463
MSN	CR201_G0011084	ENSPPYP00000022855	ENSPPYP00000003856	MSN isoform 6.	CD44 isoform 1.	0.898
MSN	RAC2	ENSPPYP00000022855	ENSPPYP00000013154	MSN isoform 6.	Rac family small GTPase 2.	0.473
RAC2	MSN	ENSPPYP00000013154	ENSPPYP00000022855	Rac family small GTPase 2.	MSN isoform 6.	0.473
RAC2	S100A8	ENSPPYP00000013154	ENSPPYP00000000951	Rac family small GTPase 2.	Protein S100; Belongs to the S-100 family.	0.494
RAC2	S100A9	ENSPPYP00000013154	ENSPPYP00000000953	Rac family small GTPase 2.	Protein S100; Belongs to the S-100 family.	0.417
RAC2	SEMA4D	ENSPPYP00000013154	ENSPPYP00000021695	Rac family small GTPase 2.	SEMA4D isoform 10; Belongs to the semaphorin family.	0.418
RAC2	ZAP70	ENSPPYP00000013154	ENSPPYP00000013469	Rac family small GTPase 2.	Tyrosine-protein kinase.	0.459
S100A8	CR201_G0011084	ENSPPYP00000000951	ENSPPYP00000003856	Protein S100; Belongs to the S-100 family.	CD44 isoform 1.	0.714
S100A8	IL1B	ENSPPYP00000000951	ENSPPYP00000013573	Protein S100; Belongs to the S-100 family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.463
S100A8	RAC2	ENSPPYP00000000951	ENSPPYP00000013154	Protein S100; Belongs to the S-100 family.	Rac family small GTPase 2.	0.494
S100A8	S100A9	ENSPPYP00000000951	ENSPPYP00000000953	Protein S100; Belongs to the S-100 family.	Protein S100; Belongs to the S-100 family.	0.999
S100A9	CR201_G0011084	ENSPPYP00000000953	ENSPPYP00000003856	Protein S100; Belongs to the S-100 family.	CD44 isoform 1.	0.430