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NEDD4 | E3 ubiquitin-protein ligase. (937 aa) | ||||
TRAF3IP2 | TRAF3 interacting protein 2. (572 aa) | ||||
RNF4 | Ring finger protein 4. (190 aa) | ||||
UBE2NL | Ubiquitin conjugating enzyme E2 N like (gene/pseudogene). (152 aa) | ||||
TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa) | ||||
TRAF1 | TNF receptor-associated factor. (416 aa) | ||||
CR201_G0001895 | CDKN2A isoform 2. (173 aa) | ||||
UBE2V2 | Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity); Belongs to the ubiquitin-c [...] (145 aa) | ||||
TRIM56 | TRIM56 isoform 1. (755 aa) | ||||
CR201_G0036895 | PRKN isoform 8. (335 aa) | ||||
RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (462 aa) | ||||
RNF5 | Ring finger protein 5. (180 aa) | ||||
RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa) | ||||
UBE2E2 | Ubiquitin conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa) | ||||
ARIH2 | RBR-type E3 ubiquitin transferase. (456 aa) | ||||
UBE2E3 | Ubiquitin conjugating enzyme E2 E3; Belongs to the ubiquitin-conjugating enzyme family. (207 aa) | ||||
PELI1 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa) | ||||
TMEM189-UBE2V1 | Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repa [...] (329 aa) | ||||
ITCH | E3 ubiquitin-protein ligase. (849 aa) | ||||
ENSPPYP00000012086 | annotation not available (110 aa) | ||||
ENSPPYP00000011890 | annotation not available (224 aa) | ||||
UBE2S | UBE2S isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (222 aa) | ||||
FBXW9 | F-box and WD repeat domain containing 9. (458 aa) | ||||
RNF126 | RNF126 isoform 1. (240 aa) | ||||
RNF152 | Ring finger protein 152. (203 aa) | ||||
RNF213 | RNF213 isoform 1. (4365 aa) | ||||
UBE2O | Ubiquitin conjugating enzyme E2 O. (1293 aa) | ||||
ENSPPYP00000009265 | annotation not available (102 aa) | ||||
RNF135 | Ring finger protein 135. (432 aa) | ||||
UBE2G1 | Ubiquitin conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. (170 aa) | ||||
WWP2 | E3 ubiquitin-protein ligase. (874 aa) | ||||
BFAR | Bifunctional apoptosis regulator. (450 aa) | ||||
STUB1 | STIP1 homology and U-box containing protein 1. (303 aa) | ||||
TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa) | ||||
HECTD1 | HECT domain E3 ubiquitin protein ligase 1. (2610 aa) | ||||
UBE2N | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa) | ||||
TRIM21 | TRIM21 isoform 1. (368 aa) | ||||
TRIM5 | Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] (493 aa) | ||||
TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (604 aa) | ||||
ZFP91 | E3 ubiquitin-protein ligase ZFP91 isoform X1. (524 aa) | ||||
PRPF19 | PRPF19 isoform 1. (523 aa) | ||||
PELI3 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (445 aa) | ||||
RNF186 | RNF186 isoform 1. (227 aa) | ||||
RNF115 | Ring finger protein 115. (304 aa) | ||||
UBE2T | Ubiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (197 aa) | ||||
TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa) | ||||
TRIM27 | Tripartite motif containing 27. (513 aa) | ||||
UBE2D4 | UBE2D4 isoform 3; Belongs to the ubiquitin-conjugating enzyme family. (171 aa) |