STRINGSTRING
NEDD4 NEDD4 TRAF3IP2 TRAF3IP2 RNF4 RNF4 UBE2NL UBE2NL TRAF2 TRAF2 TRAF1 TRAF1 CR201_G0001895 CR201_G0001895 UBE2V2 UBE2V2 TRIM56 TRIM56 CR201_G0036895 CR201_G0036895 RNF8 RNF8 RNF5 RNF5 RNF168 RNF168 UBE2E2 UBE2E2 ARIH2 ARIH2 UBE2E3 UBE2E3 PELI1 PELI1 TMEM189-UBE2V1 TMEM189-UBE2V1 ITCH ITCH ENSPPYP00000012086 ENSPPYP00000012086 ENSPPYP00000011890 ENSPPYP00000011890 UBE2S UBE2S FBXW9 FBXW9 RNF126 RNF126 RNF152 RNF152 RNF213 RNF213 UBE2O UBE2O ENSPPYP00000009265 ENSPPYP00000009265 RNF135 RNF135 UBE2G1 UBE2G1 WWP2 WWP2 BFAR BFAR STUB1 STUB1 TRAF3 TRAF3 HECTD1 HECTD1 UBE2N UBE2N TRIM21 TRIM21 TRIM5 TRIM5 TRAF6 TRAF6 ZFP91 ZFP91 PRPF19 PRPF19 PELI3 PELI3 RNF186 RNF186 RNF115 RNF115 UBE2T UBE2T TRAF5 TRAF5 TRIM27 TRIM27 UBE2D4 UBE2D4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NEDD4E3 ubiquitin-protein ligase. (937 aa)
TRAF3IP2TRAF3 interacting protein 2. (572 aa)
RNF4Ring finger protein 4. (190 aa)
UBE2NLUbiquitin conjugating enzyme E2 N like (gene/pseudogene). (152 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
TRAF1TNF receptor-associated factor. (416 aa)
CR201_G0001895CDKN2A isoform 2. (173 aa)
UBE2V2Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity); Belongs to the ubiquitin-c [...] (145 aa)
TRIM56TRIM56 isoform 1. (755 aa)
CR201_G0036895PRKN isoform 8. (335 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (462 aa)
RNF5Ring finger protein 5. (180 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
UBE2E2Ubiquitin conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
ARIH2RBR-type E3 ubiquitin transferase. (456 aa)
UBE2E3Ubiquitin conjugating enzyme E2 E3; Belongs to the ubiquitin-conjugating enzyme family. (207 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
TMEM189-UBE2V1Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repa [...] (329 aa)
ITCHE3 ubiquitin-protein ligase. (849 aa)
ENSPPYP00000012086annotation not available (110 aa)
ENSPPYP00000011890annotation not available (224 aa)
UBE2SUBE2S isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (222 aa)
FBXW9F-box and WD repeat domain containing 9. (458 aa)
RNF126RNF126 isoform 1. (240 aa)
RNF152Ring finger protein 152. (203 aa)
RNF213RNF213 isoform 1. (4365 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (1293 aa)
ENSPPYP00000009265annotation not available (102 aa)
RNF135Ring finger protein 135. (432 aa)
UBE2G1Ubiquitin conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
WWP2E3 ubiquitin-protein ligase. (874 aa)
BFARBifunctional apoptosis regulator. (450 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa)
TRIM21TRIM21 isoform 1. (368 aa)
TRIM5Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] (493 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (604 aa)
ZFP91E3 ubiquitin-protein ligase ZFP91 isoform X1. (524 aa)
PRPF19PRPF19 isoform 1. (523 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (445 aa)
RNF186RNF186 isoform 1. (227 aa)
RNF115Ring finger protein 115. (304 aa)
UBE2TUbiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (197 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
TRIM27Tripartite motif containing 27. (513 aa)
UBE2D4UBE2D4 isoform 3; Belongs to the ubiquitin-conjugating enzyme family. (171 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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