STRINGSTRING
PMVK PMVK LRP8 LRP8 CR201_G0005896 CR201_G0005896 ENSPPYP00000008314 ENSPPYP00000008314 CES1 CES1 OSBPL7 OSBPL7 NFE2L1 NFE2L1 SMAD2 SMAD2 GRAMD1A GRAMD1A LRP6 LRP6 TGFB1 TGFB1 MLC1 MLC1 INHBB INHBB GRAMD1C GRAMD1C CYP8B1 CYP8B1 TGFBR2 TGFBR2 CCR5 CCR5 GPLD1 GPLD1 INHBA INHBA SMO SMO CYP7A1 CYP7A1 PTCH1 PTCH1 TGFBR1 TGFBR1 ABCA2 ABCA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PMVKPhosphomevalonate kinase. (192 aa)
LRP8LRP8 isoform 1. (955 aa)
CR201_G0005896GRAMD1B isoform 5. (590 aa)
ENSPPYP00000008314Liver carboxylesterase 1-like isoform X1. (246 aa)
CES1Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (542 aa)
OSBPL7Oxysterol-binding protein; Belongs to the OSBP family. (842 aa)
NFE2L1Endoplasmic reticulum membrane sensor NFE2L1; [Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (By similarity). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (By similarity). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into [...] (788 aa)
SMAD2Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] (467 aa)
GRAMD1AGRAMD1A isoform 3. (750 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1000 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
MLC1MLC1 isoform 1. (426 aa)
INHBBINHBB isoform 1. (273 aa)
GRAMD1CProtein Aster-C; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol [...] (659 aa)
CYP8B1Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (501 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
GPLD1GPLD1 isoform 2. (779 aa)
INHBAInhibin subunit beta A. (426 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
PTCH1PTCH1 isoform 7. (1429 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
ABCA2ABCA2 isoform 9. (2330 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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