STRINGSTRING
IRF6 IRF6 CD34 CD34 PRRX1 PRRX1 PBX1 PBX1 WNT2B WNT2B CDKN2C CDKN2C YTHDF2 YTHDF2 KDF1 KDF1 SFN SFN CR201_G0023542 CR201_G0023542 TIAL1 TIAL1 HMX2 HMX2 FGF4 FGF4 OVOL1 OVOL1 WNT11 WNT11 YAP1 YAP1 ETV6 ETV6 WNT10B WNT10B WNT1 WNT1 RARG RARG SART3 SART3 TBX3 TBX3 FGF9 FGF9 BRCA2 BRCA2 LIG4 LIG4 ELL3 ELL3 TP53 TP53 CTC1 CTC1 IFT20 IFT20 NF1 NF1 RNF43 RNF43 WNT3 WNT3 AXIN2 AXIN2 SOX9 SOX9 HOXB4 HOXB4 BABAM1 BABAM1 NDUFA13 NDUFA13 TGFB1 TGFB1 ERCC2 ERCC2 RUNX1 RUNX1 ZNRF3 ZNRF3 WNT7B WNT7B SIX2 SIX2 XRCC5 XRCC5 WNT5A WNT5A ARIH2 ARIH2 CTNNB1 CTNNB1 TRIM71 TRIM71 RARB RARB CR201_G0007803 CR201_G0007803 MECOM MECOM TP63 TP63 SFRP2 SFRP2 SCRG1 SCRG1 FGF10 FGF10 CEP120 CEP120 RUNX2 RUNX2 CD109 CD109 NR2E1 NR2E1 BYSL BYSL GLI3 GLI3 HOXA3 HOXA3 ABCB1 ABCB1 SHH SHH SNAI2 SNAI2 OSR2 OSR2 SHB SHB NFIB NFIB PTCH1 PTCH1 NKAP NKAP NES NES ID4 ID4 KDR KDR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IRF6IRF6 isoform 2. (467 aa)
CD34CD34 isoform 1. (327 aa)
PRRX1PRRX1 isoform 3. (216 aa)
PBX1PBX homeobox 1. (430 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
YTHDF2YTHDF2 isoform 2. (494 aa)
KDF1KDF1 isoform 1. (395 aa)
SFNSFN isoform 1; Belongs to the 14-3-3 family. (248 aa)
CR201_G0023542Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (166 aa)
TIAL1TIAL1 isoform 5. (391 aa)
HMX2HMX2 isoform 1. (266 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
OVOL1OVOL1 isoform 1. (239 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
YAP1YAP1 isoform 2. (326 aa)
ETV6ETV6 isoform 1. (452 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (317 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
RARGRARG isoform 5. (469 aa)
SART3Squamous cell carcinoma antigen recognized by T-cells 3; U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation. Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites. May also function as a substrate-targeting factor [...] (963 aa)
TBX3T-box transcription factor 3. (743 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
BRCA2BRCA2 isoform 1. (3415 aa)
LIG4DNA ligase 4; Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. (911 aa)
ELL3ELL3 isoform 1. (397 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
CTC1CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...] (1214 aa)
IFT20IFT20 isoform 6. (158 aa)
NF1NF1 isoform 6. (2838 aa)
RNF43RNF43 isoform 2. (452 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
AXIN2AXIN2 isoform 1. (843 aa)
SOX9SRY-box transcription factor 9. (509 aa)
HOXB4HOXB4 isoform 1. (251 aa)
BABAM1BRISC and BRCA1-A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cl [...] (328 aa)
NDUFA13NDUFA13 isoform 1. (415 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
ERCC2ERCC2 isoform 1. (729 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
ZNRF3ZNRF3 isoform 2. (881 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
SIX2SIX homeobox 2. (291 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (473 aa)
ARIH2RBR-type E3 ubiquitin transferase. (456 aa)
CTNNB1CTNNB1 isoform 2. (781 aa)
TRIM71TRIM71 isoform 1. (867 aa)
RARBRARB isoform 2. (526 aa)
CR201_G0007803SHOX2 isoform 5. (151 aa)
MECOMMDS1 and EVI1 complex locus. (1051 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
SCRG1Stimulator of chondrogenesis 1. (98 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
CEP120Centrosomal protein 120. (986 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (589 aa)
CD109CD109 isoform 3. (1445 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
BYSLBYSL isoform 1. (224 aa)
GLI3GLI3 isoform 3. (1580 aa)
HOXA3HOXA3 isoform 3. (443 aa)
ABCB1ABCB1 isoform 4. (1280 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (460 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
OSR2OSR2 isoform 10. (312 aa)
SHBSHB isoform 1. (398 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (561 aa)
PTCH1PTCH1 isoform 7. (1429 aa)
NKAPNFKB activating protein. (416 aa)
NESNES isoform 1; Belongs to the intermediate filament family. (1632 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.