Your Input: | |
| | NPHP4 | NPHP4 isoform 5. (1375 aa) |
| | APC | Adenomatous polyposis coli protein isoform X2. (2861 aa) |
| | BMP2 | Bone morphogenetic protein 2. (396 aa) |
| | EMD | EMD isoform 1. (253 aa) |
| | CR201_G0031402 | FRMD8 isoform 1. (462 aa) |
| | AMER1 | APC membrane recruitment protein 1. (1136 aa) |
| | OTUD5 | OTUD5 isoform 2. (533 aa) |
| | NOTCH1 | NOTCH1 isoform 1. (2107 aa) |
| | DAB2IP | DAB2IP isoform 2. (1130 aa) |
| | INVS | INVS isoform 2. (895 aa) |
| | TLE1 | TLE1 isoform 1. (762 aa) |
| | TLE4 | TLE4 isoform 4. (743 aa) |
| | MLLT3 | MLLT3 isoform 1. (415 aa) |
| | CTHRC1 | CTHRC1 isoform 3. (232 aa) |
| | FZD6 | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (706 aa) |
| | STK3 | STK3 isoform 3. (491 aa) |
| | TMEM64 | TMEM64 isoform 1. (380 aa) |
| | SOX17 | SRY-box transcription factor 17. (416 aa) |
| | SNAI2 | Snail family transcriptional repressor 2. (268 aa) |
| | DKK4 | Dickkopf WNT signaling pathway inhibitor 4. (224 aa) |
| | CR201_G0033322 | SFRP1 isoform 1. (260 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (460 aa) |
| | CAV1 | Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...] (178 aa) |
| | FZD1 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (649 aa) |
| | SOSTDC1 | Sclerostin domain-containing protein 1; Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. Enhances Wnt signaling and inhibits TGF-beta signaling. May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction (By similarity). (206 aa) |
| | SFRP4 | Secreted frizzled related protein 4. (346 aa) |
| | GLI3 | GLI3 isoform 3. (1580 aa) |
| | HECW1 | HECW1 isoform 1. (1608 aa) |
| | IGFBP1 | IGFBP1 isoform 1. (281 aa) |
| | CR201_G0036895 | PRKN isoform 8. (335 aa) |
| | LATS1 | Large tumor suppressor kinase 1. (1130 aa) |
| | ANKRD6 | Ankyrin repeat domain 6. (727 aa) |
| | TBX18 | T-box transcription factor 18. (607 aa) |
| | TPBG | Trophoblast glycoprotein. (420 aa) |
| | ENSPPYP00000018739 | annotation not available (186 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | TMEM170B | TMEM170B isoform 1. (90 aa) |
| | CR201_G0004819 | NKX2-5 isoform 1. (210 aa) |
| | G3BP1 | Ras GTPase-activating protein-binding protein 1; ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RN [...] (466 aa) |
| | CSNK1A1 | CSNK1A1 isoform 6; Belongs to the protein kinase superfamily. (365 aa) |
| | MCC | MCC isoform 3. (829 aa) |
| | ISL1 | ISL1 isoform 1. (349 aa) |
| | DAB2 | DAB adaptor protein 2. (770 aa) |
| | NKD2 | NKD2 isoform 1. (455 aa) |
| | SFRP2 | Secreted frizzled related protein 2. (295 aa) |
| | TMEM131L | TMEM131L isoform 3. (1609 aa) |
| | JADE1 | Jade family PHD finger 1. (842 aa) |
| | DKK2 | DKK2 isoform 3. (186 aa) |
| | SHISA3 | Shisa family member 3. (238 aa) |
| | SOX2 | SRY-box transcription factor 2. (319 aa) |
| | SIAH2 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa) |
| | WWTR1 | WW domain containing transcription regulator 1. (400 aa) |
| | PPP2R3A | PPP2R3A isoform 2. (529 aa) |
| | RBMS3 | RNA-binding motif, single-stranded-interacting protein 3; Binds poly(A) and poly(U) oligoribonucleotides. (457 aa) |
| | CTNNB1 | CTNNB1 isoform 2. (781 aa) |
| | LIMD1 | LIM domains containing 1. (676 aa) |
| | ENSPPYP00000015537 | annotation not available (259 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (473 aa) |
| | GSK3B | GSK3B isoform 2; Belongs to the protein kinase superfamily. (380 aa) |
| | FRZB | Secreted frizzled-related protein 3; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development (By similarity). (325 aa) |
| | LOC100438930 | MDK isoform 6. (143 aa) |
| | RBX1 | RBX1 isoform 1. (108 aa) |
| | CBY1 | Chibby family member 1, beta catenin antagonist. (169 aa) |
| | SOX10 | SOX10 isoform 2. (436 aa) |
| | KREMEN1 | Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (467 aa) |
| | ZNRF3 | ZNRF3 isoform 2. (881 aa) |
| | STK4 | STK4 isoform 1. (474 aa) |
| | FERMT1 | Fermitin family homolog 1; Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites (By similarity); Belongs to the kindlin family. (677 aa) |
| | FUZ | Fuzzy planar cell polarity protein. (418 aa) |
| | DKKL1 | DKKL1 isoform 3. (241 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (418 aa) |
| | DACT3 | DACT3 isoform 2. (516 aa) |
| | GSK3A | Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa) |
| | CR201_G0044248 | AES isoform 2. (170 aa) |
| | TLE2 | TLE2 isoform 1. (604 aa) |
| | CR201_G0044246 | TLE6 isoform 2. (373 aa) |
| | APC2 | APC2 isoform 1. (2148 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa) |
| | CR201_G0021182 | NOTUM isoform 1. (370 aa) |
| | SLC9A3R1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (357 aa) |
| | SOX9 | SRY-box transcription factor 9. (509 aa) |
| | AXIN2 | AXIN2 isoform 1. (843 aa) |
| | IGFBP4 | IGFBP4 isoform 1. (258 aa) |
| | SOST | SOST isoform 1. (245 aa) |
| | NOG | Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa) |
| | CR201_G0035310 | SHISA6 isoform 3. (324 aa) |
| | TMEM88 | Transmembrane protein 88. (159 aa) |
| | AMFR | AMFR isoform 1. (548 aa) |
| | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD; Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regul [...] (956 aa) |
| | NKD1 | NKD inhibitor of WNT signaling pathway 1. (470 aa) |
| | CR201_G0054585 | AXIN1 isoform 6. (551 aa) |
| | MESP1 | Mesoderm posterior bHLH transcription factor 1. (269 aa) |
| | TLE3 | TLE family member 3, transcriptional corepressor. (769 aa) |
| | GREM1 | Gremlin. (184 aa) |
| | CCDC88C | CCDC88C isoform 2. (1924 aa) |
| | DACT1 | Dishevelled binding antagonist of beta catenin 1. (837 aa) |
| | CHD8 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2581 aa) |
| | UBAC2 | UBAC2 isoform 5. (392 aa) |
| | FOXO1 | FOXO1 isoform 1. (654 aa) |
| | CSNK1A1L | Casein kinase 1 alpha 1 like; Belongs to the protein kinase superfamily. (337 aa) |
| | AMER2 | AMER2 isoform 1. (546 aa) |
| | LATS2 | Non-specific serine/threonine protein kinase. (1098 aa) |
| | SCYL2 | SCYL2 isoform 1. (924 aa) |
| | DDIT3 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa) |
| | GLI1 | GLI family zinc finger 1. (1106 aa) |
| | PFDN5 | Prefoldin subunit 5; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC (By similarity). (154 aa) |
| | LMBR1L | Protein LMBR1L; Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta- catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis (By similarity). (489 aa) |
| | PRICKLE1 | Prickle planar cell polarity protein 1. (831 aa) |
| | PTPRO | PTPRO isoform 5. (1151 aa) |
| | FZD4 | FZD4 isoform 1; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | TPBGL | TPBGL isoform 1. (226 aa) |
| | DKK3 | DKK3 isoform 2. (413 aa) |
| | LRP4 | LRP4 isoform 2. (1900 aa) |
| | CTNND1 | CTNND1 isoform 19. (968 aa) |
| | SDHAF2 | Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (166 aa) |
| | CR201_G0012836 | TCF7L2 isoform 2. (430 aa) |
| | LZTS2 | Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa) |
| | SFRP5 | SFRP5 isoform 1. (147 aa) |
| | DKK1 | Dickkopf-like protein 1. (266 aa) |
| | BICC1 | BICC1 isoform 1. (918 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (211 aa) |
| | DRAXIN | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (350 aa) |
| | NPPA | Natriuretic peptide A. (159 aa) |
| | PTPRU | PTPRU isoform 5. (682 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] (482 aa) |
| | TNN | TNN isoform 1. (1237 aa) |
| | SOX13 | SRY-box transcription factor 13. (623 aa) |
